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One bite at a time : = Exploring the immune-enhancing potential of dietary fiber for human health.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	One bite at a time :/
其他題名:	Exploring the immune-enhancing potential of dietary fiber for human health.
作者:	Moerings, Bart G. J.
面頁冊數:	1 online resource (243 pages)
附註:	Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
Contained By:	Dissertations Abstracts International85-12B.
標題:	Infections. -
電子資源:	click for full text (PQDT)
ISBN:	9798382829319

One bite at a time : = Exploring the immune-enhancing potential of dietary fiber for human health.
Moerings, Bart G. J.

One bite at a time :Exploring the immune-enhancing potential of dietary fiber for human health. - 1 online resource (243 pages)

Source: Dissertations Abstracts International, Volume: 85-12, Section: B.

Thesis (Ph.D.)--Wageningen University and Research, 2024.

Includes bibliographical references

Dietary fibers have been recognized for their impact on the gut microbiota and contribution to the development and supporting the immune system. These effects hold particular promise for individuals with compromised immune systems and the elderly. Unraveling the specific mechanisms through which dietary fibers enhance immunity opens avenues for developing novel food products with immune-boosting attributes. Here, we focused on two classes of commonly consumed immune-active dietary fibers; 1) β-glucans, a class of dietary fibers consisting of glucose subunits that belong to the non-digestible polysaccharide subclass hemicellulose, and 2) arabinoxylans, consisting mainly of arabinose and xylose subunits and a major component of dietary fiber found in cereals, such as oat, wheat, corn, rye, and rice bran. Activation of the innate immune system holds the promise of improving responses to subsequent stimuli, a phenomenon referred to as "trained innate immunity". This concept originates from the observation that, following a primary infection characterized by epigenetic remodeling and metabolic pathway rewiring, there is an enhanced innate immune response to both secondary and unrelated infections or stimuli. When the initial trigger remains accessible to cells over time the mechanistical processes might be identical, one could consider this "priming". While research demonstrates β-glucans' direct immune stimulation and potential to induce trained immunity, most evidence relies on invasive systemic administration. Limited data exist regarding the induction of trained immunity by orally ingested β-glucans and arabinoxylans. The aim of this thesis was to investigate whether oral intake of these dietary fibers can also induce trained immunity.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798382829319Subjects--Topical Terms:

882242
Infections.
Index Terms--Genre/Form:

554714
Electronic books.

One bite at a time : = Exploring the immune-enhancing potential of dietary fiber for human health.
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520 $a Dietary fibers have been recognized for their impact on the gut microbiota and contribution to the development and supporting the immune system. These effects hold particular promise for individuals with compromised immune systems and the elderly. Unraveling the specific mechanisms through which dietary fibers enhance immunity opens avenues for developing novel food products with immune-boosting attributes. Here, we focused on two classes of commonly consumed immune-active dietary fibers; 1) β-glucans, a class of dietary fibers consisting of glucose subunits that belong to the non-digestible polysaccharide subclass hemicellulose, and 2) arabinoxylans, consisting mainly of arabinose and xylose subunits and a major component of dietary fiber found in cereals, such as oat, wheat, corn, rye, and rice bran. Activation of the innate immune system holds the promise of improving responses to subsequent stimuli, a phenomenon referred to as "trained innate immunity". This concept originates from the observation that, following a primary infection characterized by epigenetic remodeling and metabolic pathway rewiring, there is an enhanced innate immune response to both secondary and unrelated infections or stimuli. When the initial trigger remains accessible to cells over time the mechanistical processes might be identical, one could consider this "priming". While research demonstrates β-glucans' direct immune stimulation and potential to induce trained immunity, most evidence relies on invasive systemic administration. Limited data exist regarding the induction of trained immunity by orally ingested β-glucans and arabinoxylans. The aim of this thesis was to investigate whether oral intake of these dietary fibers can also induce trained immunity.
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