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Vascular smooth muscle function in hypertension

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Vascular smooth muscle function in hypertension / Theodora Szasz, Rita C.A. Tostes
Author:	Szasz, Theodora,
other author:	Tostes, Rita C. A.,
Description:	1 PDF (vii, 96 pages) :illustrations :
Notes:	Part of : Colloquium digital library of life sciences
Subject:	Hypertension -
Online resource:	http://portal.igpublish.com/iglibrary/search/MCPB0006280.html
ISBN:	9781615046850

Vascular smooth muscle function in hypertension
Szasz, Theodora,

Vascular smooth muscle function in hypertension [electronic resource] /Theodora Szasz, Rita C.A. Tostes - 1 PDF (vii, 96 pages) :illustrations - Colloquium series on integrated systems physiology,# 612154-5626 ;. - Colloquium digital library of life sciences.

Part of : Colloquium digital library of life sciences

Includes bibliographical references (pages 69-94)

1. Historical considerations on early physiological studies of the cardiovascular system --

Abstract freely available; full-text restricted to subscribers or individual document purchasers

Google scholar

Hypertension is defined by an increase in systemic blood pressure above limits considered normal, currently set at 140 mmHg for systolic and 90 mmHg for diastolic pressure [1]. Assuming central venous pressure to be near zero, mean arterial pressure is determined by the product of total peripheral resistance and cardiac output. In most cases of essential hypertension, as well as in animal models of hypertension, cardiac output and its main determinants, stroke volume and heart rate, are normal, whereas total peripheral resistance is increased. Total peripheral resistance is influenced by a number of factors described by the Poiseuille's law, the most significant of which by far is the diameter of blood vessels of the arterial tree

ISBN: 9781615046850

Standard No.: 10.4199 / C00129ED1V01Y201503ISP061doiSubjects--Topical Terms:

644568
Hypertension
Index Terms--Genre/Form:

761329
Electronic books

LC Class. No.: RC685.H8 / S928 2017

Dewey Class. No.: 616.132

National Library of Medicine Call No.: WG 34 / S928v 2017

Vascular smooth muscle function in hypertension
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245 1 0 $a Vascular smooth muscle function in hypertension $h [electronic resource] / $c Theodora Szasz, Rita C.A. Tostes
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300 $a 1 PDF (vii, 96 pages) : $b illustrations
336 $a text $2 rdacontent
337 $a electronic $2 isbdmedia
338 $a online resource $2 rdacarrier
490 1 $a Colloquium series on integrated systems physiology, $x 2154-5626 ; $v # 61
500 $a Part of : Colloquium digital library of life sciences
504 $a Includes bibliographical references (pages 69-94)
505 0 $a 1. Historical considerations on early physiological studies of the cardiovascular system --
505 8 $a 2. An overview of vascular physiology -- 2.1 A teleological perspective on circulation -- 2.2 Blood flow regulation -- 2.3 Some historical perspectives on the contraction of muscles -- 2.4 Some historical perspectives on the local mechanisms that regulate blood flow --
505 8 $a 3. Alterations in vascular smooth muscle contraction in hypertension -- 3.1 Functional vascular changes in hypertension - - 3.2 Some historical perspectives on experimental models of hypertension --
505 8 $a 4. Mechanisms of vascular smooth muscle dysfunction in hypertension -- 4.1 Alterations in receptor number/affinity -- 4.2 Calcium handling -- 4.3 Calcium sensitization -- 4.4 Membrane properties -- 4.5 Actin cytoskeleton --
505 8 $a 5. Vascular remodeling in hypertension --
505 8 $a 6. Vascular smooth muscle cell interactions in the vascular wall --
505 8 $a 7. Concluding remarks -- References -- Author biographies and acknowledgments
506 $a Abstract freely available; full-text restricted to subscribers or individual document purchasers
510 0 $a Google scholar
510 0 $a Google book search
520 $a Hypertension is defined by an increase in systemic blood pressure above limits considered normal, currently set at 140 mmHg for systolic and 90 mmHg for diastolic pressure [1]. Assuming central venous pressure to be near zero, mean arterial pressure is determined by the product of total peripheral resistance and cardiac output. In most cases of essential hypertension, as well as in animal models of hypertension, cardiac output and its main determinants, stroke volume and heart rate, are normal, whereas total peripheral resistance is increased. Total peripheral resistance is influenced by a number of factors described by the Poiseuille's law, the most significant of which by far is the diameter of blood vessels of the arterial tree
520 $a Since blood vessel diameter is a reflection of both vascular structure and active regulation of vascular tone through mechanisms of vasoconstriction and vasodilatation, it is generally considered that alterations in total peripheral resistance are directly determined by alterations in vascular smooth muscle structure and/or function. Thus, complex blood pressure regulation systems, including renal, nervous, endocrine, immune, and others, in their turn influenced by genetic or environmental factors, converge upon the same molecular mechanisms that control the structure and function of vascular smooth muscle. In this work, rather than providing the exhaustive list of modifications in the blood pressure regulating systems that ultimately affect the vasculature in hypertension, we will focus on the structural and functional alterations of vascular smooth muscle per se during hypertension
530 $a Also available in print
650 0 $a Hypertension $3 644568
650 0 $a Vascular smooth muscle $3 1176172
655 4 $a Electronic books $2 local. $3 761329
700 1 $a Tostes, Rita C. A., $e author $3 1176170
776 0 8 $i Print version: $z 9781615046843
830 0 $a Colloquium digital library of life sciences $3 1176171
830 0 $a Colloquium series on integrated systems physiology ; $v 25. $3 915284
856 4 0 $u http://portal.igpublish.com/iglibrary/search/MCPB0006280.html