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The Effects of Prenatal and Perinatal Alcohol Exposure on Adult Mouse Behavior.

紀錄類型:	書目-語言資料,手稿 : Monograph/item
正題名/作者:	The Effects of Prenatal and Perinatal Alcohol Exposure on Adult Mouse Behavior./
作者:	Schaeffer, Ericka Ann.
面頁冊數:	1 online resource (116 pages)
附註:	Source: Dissertations Abstracts International, Volume: 85-07, Section: B.
Contained By:	Dissertations Abstracts International85-07B.
標題:	Neurosciences. -
電子資源:	click for full text (PQDT)
ISBN:	9798381427981

The Effects of Prenatal and Perinatal Alcohol Exposure on Adult Mouse Behavior.
Schaeffer, Ericka Ann.

The Effects of Prenatal and Perinatal Alcohol Exposure on Adult Mouse Behavior. - 1 online resource (116 pages)

Source: Dissertations Abstracts International, Volume: 85-07, Section: B.

Thesis (Ph.D.)--Northern Illinois University, 2023.

Includes bibliographical references

Prenatal alcohol exposure (PAE) is a prevalent phenomenon conserved across cultures which can result in a heterogeneous set of symptoms associated with offspring development. Although there is much research characterizing the extent of disruptions in spatial and motor performance, there appears to be conflicting results dependent on the type of PAE model. Therefore, the current study aimed to investigate a more reliable and translatable model of symptoms associated with fetal alcohol syndrome disorders. The current set of experiments evaluated the effects of alcohol exposure in mice during prenatal (gestation day 4-18) and early postnatal (postnatal day 4-12) development on organization of spatial and gross motor behavior in adulthood. Results indicate spatial orientation and gait are spared; however, a dissociation in anxiety measures was observed between exposure timepoints, which was dependent on sex. Specially, PAE males and PrAE females were observed to display more behaviors indicative of anxiety. Additionally, the organization of spatial and gait behaviors appears to be spared. Future research should continue to develop translatable models of PAE as well as aiding in early detection of subtle symptoms.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798381427981Subjects--Topical Terms:

593561
Neurosciences.
Subjects--Index Terms:

Prenatal alcohol exposureIndex Terms--Genre/Form:

554714
Electronic books.

The Effects of Prenatal and Perinatal Alcohol Exposure on Adult Mouse Behavior.
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520 $a Prenatal alcohol exposure (PAE) is a prevalent phenomenon conserved across cultures which can result in a heterogeneous set of symptoms associated with offspring development. Although there is much research characterizing the extent of disruptions in spatial and motor performance, there appears to be conflicting results dependent on the type of PAE model. Therefore, the current study aimed to investigate a more reliable and translatable model of symptoms associated with fetal alcohol syndrome disorders. The current set of experiments evaluated the effects of alcohol exposure in mice during prenatal (gestation day 4-18) and early postnatal (postnatal day 4-12) development on organization of spatial and gross motor behavior in adulthood. Results indicate spatial orientation and gait are spared; however, a dissociation in anxiety measures was observed between exposure timepoints, which was dependent on sex. Specially, PAE males and PrAE females were observed to display more behaviors indicative of anxiety. Additionally, the organization of spatial and gait behaviors appears to be spared. Future research should continue to develop translatable models of PAE as well as aiding in early detection of subtle symptoms.
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