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Circuit Interactions Between the Lateral Entorhinal Cortex and Hippocampal Area CA1.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Circuit Interactions Between the Lateral Entorhinal Cortex and Hippocampal Area CA1./
Author:	Bilash, Olesia M.
Description:	1 online resource (169 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
Contained By:	Dissertations Abstracts International85-01B.
Subject:	Neurosciences. -
Online resource:	click for full text (PQDT)
ISBN:	9798379776114

Circuit Interactions Between the Lateral Entorhinal Cortex and Hippocampal Area CA1.
Bilash, Olesia M.

Circuit Interactions Between the Lateral Entorhinal Cortex and Hippocampal Area CA1. - 1 online resource (169 pages)

Source: Dissertations Abstracts International, Volume: 85-01, Section: B.

Thesis (Ph.D.)--New York University, 2023.

Includes bibliographical references

The lateral entorhinal cortex (LEC) provides multi-sensory information about environmental cues to the hippocampus. A growing body of work suggests that LEC neurons perform important functions for episodic memory processing, coding for contextually-salient elements of an environment or the experience within it. However, we know surprisingly little about the circuit interactions between LEC and the hippocampus. I combined functional circuit mapping and computational modeling to examine how long-range glutamatergic LEC projections modulate compartment-specific excitation-inhibition dynamics in hippocampal area CA1. I demonstrate that these inputs drive excitation, inhibition, and disinhibition onto CA1 pyramidal neurons through various parallel circuit pathways. Interestingly, LEC inputs can drive local dendritic spikes in CA1 pyramidal neurons, aided by the recruitment of a disinhibitory vasoactive intestinal peptide (VIP)-expressing interneuron microcircuit. My circuit mapping further reveals that LEC inputs also recruit cholecystokinin (CCK)-expressing interneurons, which a data-driven computational model predicts act as a strong suppressor of the LEC-driven dendritic spikes. These results provide a thorough characterization of the glutamatergic LEC-CA1 circuit and provide new insight into the GABAergic microcircuit mechanisms that gate non-linear dendritic computations in the hippocampus. Such neuronal computations may support compartment-specific coding of multi-sensory contextual features within the hippocampus.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798379776114Subjects--Topical Terms:

593561
Neurosciences.
Subjects--Index Terms:

DendritesIndex Terms--Genre/Form:

554714
Electronic books.

Circuit Interactions Between the Lateral Entorhinal Cortex and Hippocampal Area CA1.
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504 $a Includes bibliographical references
520 $a The lateral entorhinal cortex (LEC) provides multi-sensory information about environmental cues to the hippocampus. A growing body of work suggests that LEC neurons perform important functions for episodic memory processing, coding for contextually-salient elements of an environment or the experience within it. However, we know surprisingly little about the circuit interactions between LEC and the hippocampus. I combined functional circuit mapping and computational modeling to examine how long-range glutamatergic LEC projections modulate compartment-specific excitation-inhibition dynamics in hippocampal area CA1. I demonstrate that these inputs drive excitation, inhibition, and disinhibition onto CA1 pyramidal neurons through various parallel circuit pathways. Interestingly, LEC inputs can drive local dendritic spikes in CA1 pyramidal neurons, aided by the recruitment of a disinhibitory vasoactive intestinal peptide (VIP)-expressing interneuron microcircuit. My circuit mapping further reveals that LEC inputs also recruit cholecystokinin (CCK)-expressing interneurons, which a data-driven computational model predicts act as a strong suppressor of the LEC-driven dendritic spikes. These results provide a thorough characterization of the glutamatergic LEC-CA1 circuit and provide new insight into the GABAergic microcircuit mechanisms that gate non-linear dendritic computations in the hippocampus. Such neuronal computations may support compartment-specific coding of multi-sensory contextual features within the hippocampus.
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653 $a Interneurons
653 $a Neural circuit
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