國立虎尾科技大學 |

Aging = how science works /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Aging/ by Carsten Carlberg, Stine M. Ulven, Eunike Velleuer.
其他題名:	how science works /
作者:	Carlberg, Carsten.
其他作者:	Ulven, Stine Marie.
出版者:	Cham :Springer Nature Switzerland : : 2024.,
面頁冊數:	xv, 175 p. :ill. (some col.), digital ; : 24 cm.;
Contained By:	Springer Nature eBook
標題:	Aging - Molecular aspects. -
電子資源:	https://doi.org/10.1007/978-3-031-61257-2
ISBN:	9783031612572

Aging = how science works /
Carlberg, Carsten.

Aginghow science works /[electronic resource] :by Carsten Carlberg, Stine M. Ulven, Eunike Velleuer. - Cham :Springer Nature Switzerland :2024. - xv, 175 p. :ill. (some col.), digital ;24 cm.

1. The human genome, development and evolution -- 2. Gene expression and epigenetics -- 3. Epigenetics and aging -- 4. Molecular and cellular basis of aging -- 5. Nutrition and aging -- 6. Aging and immunity -- 7. Central role of aging during chronic diseases -- 8. Aging and cancer -- 9. Healthy aging.

Aging is a topic that concerns all of us, since none of us can escape it. The molecular and cellular process is built in every of the billions of cells forming our body. Some of these cells, such as immune cells and red blood cells, live only for a few days to weeks and get life-long constantly replaced by cells produced in the bone marrow. In contrast, there are cells, such as neurons and memory lymphocytes, that get as old as we get. The process of aging limits our maximal life span, which is for our humans 120 years. However, only a very few individuals reached this age. How did their life differ from others that died decades earlier? Is it just the absence of life threatening disease paired with a more healthy life style? Or is it build in in our genome or epigenome? In this book we try to give answers to these questions from the perspectives of evolution, our genome, the epigenomes of our different tissues and cell types and the functionality of our cells. We should try to understand ourselves in detail as well as in a global setting. Basic biology explains cellular mechanisms, such as growth, differentiation, and cell death, which make life as a whole possible. Every (human) organism represents a complex interplay between hundreds of different cell types forming distinctive tissues and organs with specialized tasks. These processes need to be highly orchestrated especially during development, maintenance and aging. Studying the cellular and molecular basis of aging is one of the most fascinating areas but also a great challenge. Nevertheless, research made the biggest steps in elucidating biological processes via studying malfunctions of normal mechanisms leading to different diseases, such as progeroid syndrome and cancer. We will start this book with the understanding of the human genome in relation to principles of evolution. Then we will explain the basics of gene regulation and epigenetics, i.e., the interplay of transcription factors and chromatin. Next, we will shift to cellular mechanisms of aging and discuss then the impact of nutrition and immunity on the aging process. In the following the relation of aging to so-called aging-related common diseases, such as type 2 diabetes, atherosclerosis, cancer and Alzheimer. Do we get these diseases because we are aging or are we aging because we get one of these diseases? The book will end how we can slow down the aging process so that we can age healthy. In short, healthy aging is not an option but is a must. An ancient poem says "Teach us to number our days, that we may get a heart of wisdom." It is up to each one of us and a daily decision to live a healthy lifestyle and to be aware of the unique gift of live we all have.

ISBN: 9783031612572

Standard No.: 10.1007/978-3-031-61257-2doiSubjects--Topical Terms:

582175
Aging
--Molecular aspects.

LC Class. No.: QP86

Dewey Class. No.: 571.878

Aging = how science works /
LDR:04019nam a2200325 a 4500 001 1133576
003 DE-He213
005 20240723130734.0
006 m d
007 cr nn 008maaau
008 241213s2024 sz s 0 eng d
020 $a 9783031612572 $q (electronic bk.)
020 $a 9783031612565 $q (paper)
024 7 $a 10.1007/978-3-031-61257-2 $2 doi
035 $a 978-3-031-61257-2
040 $a GP $c GP
041 0 $a eng
050 4 $a QP86
072 7 $a PSD $2 bicssc
072 7 $a SCI049000 $2 bisacsh
072 7 $a PSD $2 thema
082 0 4 $a 571.878 $2 23
090 $a QP86 $b .C278 2024
100 1 $a Carlberg, Carsten. $3 1022906
245 1 0 $a Aging $h [electronic resource] : $b how science works / $c by Carsten Carlberg, Stine M. Ulven, Eunike Velleuer.
260 $a Cham : $c 2024. $b Springer Nature Switzerland : $b Imprint: Springer,
300 $a xv, 175 p. : $b ill. (some col.), digital ; $c 24 cm.
505 0 $a 1. The human genome, development and evolution -- 2. Gene expression and epigenetics -- 3. Epigenetics and aging -- 4. Molecular and cellular basis of aging -- 5. Nutrition and aging -- 6. Aging and immunity -- 7. Central role of aging during chronic diseases -- 8. Aging and cancer -- 9. Healthy aging.
520 $a Aging is a topic that concerns all of us, since none of us can escape it. The molecular and cellular process is built in every of the billions of cells forming our body. Some of these cells, such as immune cells and red blood cells, live only for a few days to weeks and get life-long constantly replaced by cells produced in the bone marrow. In contrast, there are cells, such as neurons and memory lymphocytes, that get as old as we get. The process of aging limits our maximal life span, which is for our humans 120 years. However, only a very few individuals reached this age. How did their life differ from others that died decades earlier? Is it just the absence of life threatening disease paired with a more healthy life style? Or is it build in in our genome or epigenome? In this book we try to give answers to these questions from the perspectives of evolution, our genome, the epigenomes of our different tissues and cell types and the functionality of our cells. We should try to understand ourselves in detail as well as in a global setting. Basic biology explains cellular mechanisms, such as growth, differentiation, and cell death, which make life as a whole possible. Every (human) organism represents a complex interplay between hundreds of different cell types forming distinctive tissues and organs with specialized tasks. These processes need to be highly orchestrated especially during development, maintenance and aging. Studying the cellular and molecular basis of aging is one of the most fascinating areas but also a great challenge. Nevertheless, research made the biggest steps in elucidating biological processes via studying malfunctions of normal mechanisms leading to different diseases, such as progeroid syndrome and cancer. We will start this book with the understanding of the human genome in relation to principles of evolution. Then we will explain the basics of gene regulation and epigenetics, i.e., the interplay of transcription factors and chromatin. Next, we will shift to cellular mechanisms of aging and discuss then the impact of nutrition and immunity on the aging process. In the following the relation of aging to so-called aging-related common diseases, such as type 2 diabetes, atherosclerosis, cancer and Alzheimer. Do we get these diseases because we are aging or are we aging because we get one of these diseases? The book will end how we can slow down the aging process so that we can age healthy. In short, healthy aging is not an option but is a must. An ancient poem says "Teach us to number our days, that we may get a heart of wisdom." It is up to each one of us and a daily decision to live a healthy lifestyle and to be aware of the unique gift of live we all have.
650 0 $a Aging $x Molecular aspects. $3 582175
650 1 4 $a Molecular Biology. $3 599552
650 2 4 $a Epigenetics. $3 884396
650 2 4 $a Nutrition. $3 581367
650 2 4 $a Molecular Evolution. $3 1390272
650 2 4 $a Cancer Biology. $3 1388882
650 2 4 $a Metabolism. $3 581368
700 1 $a Ulven, Stine Marie. $3 1109836
700 1 $a Velleuer, Eunike. $e author. $1 https://orcid.org/0000-0003-4328-9556 $3 1350500
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
856 4 0 $u https://doi.org/10.1007/978-3-031-61257-2
950 $a Biomedical and Life Sciences (SpringerNature-11642)