國立虎尾科技大學 |

Development of Meta-Analysis in Biomedical Studies.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Development of Meta-Analysis in Biomedical Studies./
Author:	Li, Lie.
Description:	1 online resource (96 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 78-11(E), Section: B.
Contained By:	Dissertation Abstracts International78-11B(E).
Subject:	Statistics. -
Online resource:	click for full text (PQDT)
ISBN:	9781369866704

Development of Meta-Analysis in Biomedical Studies.
Li, Lie.

Development of Meta-Analysis in Biomedical Studies. - 1 online resource (96 pages)

Source: Dissertation Abstracts International, Volume: 78-11(E), Section: B.

Thesis (Ph.D.)

Includes bibliographical references

This research contains two topics: (1) Integrative Gene Set Enrichment Analysis Utilizing Isoform-Specific Expression; (2) Meta-Analysis of Rare Binary Events in Treatment Groups with Unequal Variability.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9781369866704Subjects--Topical Terms:

556824
Statistics.
Index Terms--Genre/Form:

554714
Electronic books.

Development of Meta-Analysis in Biomedical Studies.
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099 $a TUL $f hyy $c available through World Wide Web
100 1 $a Li, Lie. $3 1182907
245 1 0 $a Development of Meta-Analysis in Biomedical Studies.
264 0 $c 2017
300 $a 1 online resource (96 pages)
336 $a text $b txt $2 rdacontent
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500 $a Source: Dissertation Abstracts International, Volume: 78-11(E), Section: B.
500 $a Advisers: Xinlei Wang; Guanghua Xiao.
502 $a Thesis (Ph.D.) $c Southern Methodist University $d 2017.
504 $a Includes bibliographical references
520 $a This research contains two topics: (1) Integrative Gene Set Enrichment Analysis Utilizing Isoform-Specific Expression; (2) Meta-Analysis of Rare Binary Events in Treatment Groups with Unequal Variability.
520 $a Gene Set Enrichment Analysis (GSEA) aims at identifying essential pathways, or more generally, sets of biologically related genes that are involved in complex human diseases. In the past, many studies have shown that GSEA is a very useful bioinformatics tool, which plays critical roles in the innovation of disease prevention and intervention strategies. Despite its tremendous success, it is striking that conclusions of GSEA drawn from isolated studies are often sparse, and different studies may lead to inconsistent and sometimes contradictory results. Further, in the wake of next generation sequencing technologies, it has been made possible to measure genome-wide isoform-specific expression levels, calling for innovations that can utilize the unprecedented resolution. Currently, enormous amounts of data have been created from various RNA-seq experiments. All these give rise to a pressing need for developing integrative methods that allow for explicit utilization of isoform-specific expression, to combine multiple enrichment studies, in order to enhance the power, reproducibility and interpretability of the analysis. We develop and evaluate integrative GSEA methods, based on two-stage procedures, which, for the first time, allow statistically efficient use of isoform-specific expression from multiple RNA-seq experiments. Through simulation and real data analysis, we show that our methods can greatly improve the performance in identifying essential gene sets compared to existing methods that can only use gene-level expression.
520 $a Meta-analysis has been widely used to synthesize information from related studies to achieve reliable findings. However, in studies of rare events, the event counts are often low or even zero, and so standard meta-analysis methods such as fixed-effect models with continuity correction may cause substantial bias in estimation. Recently, Bhaumik et al. (2012) developed a simple average (SA) estimator for the overall treatment effect based on a random-effects (RE) model. They proved that the SA method with the continuity correction factor 0.5 (SA_0.5) is the least biased for large samples, and showed via simulation that it has superior performance when compared with other commonly used estimators. However, the RE models used in previous work are restrictive because they all assume that the variability in the treatment group is equal to or always greater than that in the control group. Under a general framework that explicitly allows treatment groups with unequal variability but assumes no direction, we prove that SA_0.5 is still the least biased for large samples. Meanwhile, to account for a trade-off between the bias and variance in estimation, we consider the mean squared error (MSE) to assess estimation efficiency and show that SA_0.5 fails to minimize the MSE. Under a new RE model that accommodates groups with unequal variability, we thoroughly compare the performance of various methods for both large and small samples via simulation, and draw conclusions about when to use which method in terms of both bias and MSE. A data example of rosiglitazone meta-analysis is used to provide further comparison.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Statistics. $3 556824
650 4 $a Health sciences. $3 1179212
650 4 $a Bioinformatics. $3 583857
655 7 $a Electronic books. $2 local $3 554714
690 $a 0463
690 $a 0566
690 $a 0715
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a Southern Methodist University. $b Statistical Science. $3 1182908
773 0 $t Dissertation Abstracts International $g 78-11B(E).
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10275140 $z click for full text (PQDT)