國立虎尾科技大學 |

Complex Systems and Computational Biology Approaches to Acute Inflammation = A Framework for Model-based Precision Medicine /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Complex Systems and Computational Biology Approaches to Acute Inflammation/ edited by Yoram Vodovotz, Gary An.
Reminder of title:	A Framework for Model-based Precision Medicine /
other author:	Vodovotz, Yoram.
Description:	IX, 312 p. 51 illus., 37 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Immunology. -
Online resource:	https://doi.org/10.1007/978-3-030-56510-7
ISBN:	9783030565107

Complex Systems and Computational Biology Approaches to Acute Inflammation = A Framework for Model-based Precision Medicine /
Complex Systems and Computational Biology Approaches to Acute InflammationA Framework for Model-based Precision Medicine /[electronic resource] :edited by Yoram Vodovotz, Gary An. - 2nd ed. 2021. - IX, 312 p. 51 illus., 37 illus. in color.online resource.

1. An Overview of the Translational Dilemma and the Need for Model-based Precision Medicine -- 2 Translational Equation-based Modeling -- 3. Agent-based Modeling in Translational Systems Biology -- 4. Integrating Data-driven and Mechanistic Modeling in Sepsis and Trauma -- 5. Therapeutics as Control: Model-based approaches for control discovery -- 6. Disorder of Systemic Inflammation in Sepsis and Trauma: A Systems Perspective -- 7. Multi-scale equation-based models: Insights for Inflammation and Physiological Variability -- 8. In silico Trials and Personalized Therapy for Sepsis and Trauma -- 9. Computational Modeling of the Coagulation Response -- 10. Disorder of Localized Inflammation in Wound Healing -- 11. Equation-based Models of Wound Healing and Collective Cell Migration -- 12. Agent-based Models of Wound Healing -- 13. Tissue realistic translational modeling of gut inflammation -- 14. Data-Driven Modeling of Liver Injury, Inflammation, and Fibrosis -- 15. Computational Modeling of Tuberculosis -- 16. The Rationale and Implementation of Model-based Precision Medicine for Inflammatory Diseases -- Index.

This second edition expands upon and updates the vital research covered in its predecessor, by presenting state-of-the-art multidisciplinary and systems-oriented approaches to complex diseases arising from and driven by the acute inflammatory response. The chapters in this volume provide an introduction to different types of computational modeling, and how these methods can be applied to specific inflammatory diseases, with a focus on providing readers a roadmap for integrating advanced mathematical and computational techniques with traditional experimental methods. In this second edition, we cover both well-established and emerging modeling methods, especially state-of-the-art machine learning approaches and the integration of data-driven and mechanistic modeling. This volume introduces the concept of Model-based Precision Medicine as an alternative approach to the current view of Precision Medicine, based on leveraging mechanistic computational modeling to decrease cost while increasing the information value of the data being obtained. By presenting the role of computational modeling as an integrated component of the research process, Complex Systems and Computational Biology Approaches to Acute Inflammation: A Framework for Model-based Precision Medicine offers a window into the recent past, the present, and the future of computationally-augmented biomedical research.

ISBN: 9783030565107

Standard No.: 10.1007/978-3-030-56510-7doiSubjects--Topical Terms:

592892
Immunology.

LC Class. No.: QR180-189.5

Dewey Class. No.: 616.079

Complex Systems and Computational Biology Approaches to Acute Inflammation = A Framework for Model-based Precision Medicine /
LDR:03976nam a22003975i 4500 001 1047840
003 DE-He213
005 20211106191657.0
007 cr nn 008mamaa
008 220103s2021 sz | s |||| 0|eng d
020 $a 9783030565107 $9 978-3-030-56510-7
024 7 $a 10.1007/978-3-030-56510-7 $2 doi
035 $a 978-3-030-56510-7
050 4 $a QR180-189.5
072 7 $a MJCM $2 bicssc
072 7 $a MED044000 $2 bisacsh
072 7 $a MJCM $2 thema
082 0 4 $a 616.079 $2 23
245 1 0 $a Complex Systems and Computational Biology Approaches to Acute Inflammation $h [electronic resource] : $b A Framework for Model-based Precision Medicine / $c edited by Yoram Vodovotz, Gary An.
250 $a 2nd ed. 2021.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2021.
300 $a IX, 312 p. 51 illus., 37 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
505 0 $a 1. An Overview of the Translational Dilemma and the Need for Model-based Precision Medicine -- 2 Translational Equation-based Modeling -- 3. Agent-based Modeling in Translational Systems Biology -- 4. Integrating Data-driven and Mechanistic Modeling in Sepsis and Trauma -- 5. Therapeutics as Control: Model-based approaches for control discovery -- 6. Disorder of Systemic Inflammation in Sepsis and Trauma: A Systems Perspective -- 7. Multi-scale equation-based models: Insights for Inflammation and Physiological Variability -- 8. In silico Trials and Personalized Therapy for Sepsis and Trauma -- 9. Computational Modeling of the Coagulation Response -- 10. Disorder of Localized Inflammation in Wound Healing -- 11. Equation-based Models of Wound Healing and Collective Cell Migration -- 12. Agent-based Models of Wound Healing -- 13. Tissue realistic translational modeling of gut inflammation -- 14. Data-Driven Modeling of Liver Injury, Inflammation, and Fibrosis -- 15. Computational Modeling of Tuberculosis -- 16. The Rationale and Implementation of Model-based Precision Medicine for Inflammatory Diseases -- Index.
520 $a This second edition expands upon and updates the vital research covered in its predecessor, by presenting state-of-the-art multidisciplinary and systems-oriented approaches to complex diseases arising from and driven by the acute inflammatory response. The chapters in this volume provide an introduction to different types of computational modeling, and how these methods can be applied to specific inflammatory diseases, with a focus on providing readers a roadmap for integrating advanced mathematical and computational techniques with traditional experimental methods. In this second edition, we cover both well-established and emerging modeling methods, especially state-of-the-art machine learning approaches and the integration of data-driven and mechanistic modeling. This volume introduces the concept of Model-based Precision Medicine as an alternative approach to the current view of Precision Medicine, based on leveraging mechanistic computational modeling to decrease cost while increasing the information value of the data being obtained. By presenting the role of computational modeling as an integrated component of the research process, Complex Systems and Computational Biology Approaches to Acute Inflammation: A Framework for Model-based Precision Medicine offers a window into the recent past, the present, and the future of computationally-augmented biomedical research.
650 0 $a Immunology. $3 592892
650 0 $a Bioinformatics. $3 583857
700 1 $a Vodovotz, Yoram. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1027351
700 1 $a An, Gary. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1027352
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783030565091
776 0 8 $i Printed edition: $z 9783030565114
776 0 8 $i Printed edition: $z 9783030565121
856 4 0 $u https://doi.org/10.1007/978-3-030-56510-7
912 $a ZDB-2-SBL
912 $a ZDB-2-SXB
950 $a Biomedical and Life Sciences (SpringerNature-11642)
950 $a Biomedical and Life Sciences (R0) (SpringerNature-43708)