國立虎尾科技大學 |

Ophthalmic Product Development = From Bench to Bedside /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Ophthalmic Product Development/ edited by Seshadri Neervannan, Uday B. Kompella.
Reminder of title:	From Bench to Bedside /
other author:	Neervannan, Seshadri.
Description:	IX, 650 p. 126 illus., 105 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Pharmaceutical chemistry. -
Online resource:	https://doi.org/10.1007/978-3-030-76367-1
ISBN:	9783030763671

Ophthalmic Product Development = From Bench to Bedside /
Ophthalmic Product DevelopmentFrom Bench to Bedside /[electronic resource] :edited by Seshadri Neervannan, Uday B. Kompella. - 1st ed. 2021. - IX, 650 p. 126 illus., 105 illus. in color.online resource. - AAPS Advances in the Pharmaceutical Sciences Series,372210-738X ;. - AAPS Advances in the Pharmaceutical Sciences Series,20.

Introduction and History of Ophthalmic Product Development -- Ocular Surface Anatomy and Physiology: Impact on Product Development -- Anatomy and Physiology of the Anterior Chamber – Impact on Product Development -- Back of the eye anatomy & physiology – Impact on product development -- Physicochemical and Biological Fundamentals for Drug Delivery to the Eye -- Topical Ophthalmic Dosage Form Development – Key Components and Critical Quality Attributes -- Intra-ocular Injectable Dosage Form Development -- Microbiological Considerations for Ophthalmic Products – Sterility, Endotoxin Limits and Preservatives -- Packaging Development – Multi-dose container closure for preservative free products, extractable/leachables from packaging, new technologies -- Liquid ophthalmic drug products – physicochemical properties, formulations and manufacturing considerations -- Emulsions for topical eye delivery: state of the art and future perspectives -- Emulsions for topical eye delivery: state of the art and future perspectives -- Microparticle Products For The Eye - preformulation, formulation, and manufacturing considerations -- NANOPARTICLE PRODUCTS FOR THE EYE: preformulation, formulation and manufacturing considerations -- Advanced Hydrogel Formulations for the Eye -- Ophthalmic Product Development for Biologics -- Implantable Devices to Treat Ophthalmic Conditions –Drug Delivery Systems -- Development of Artificial Tears Products for Ocular Conditions -- Approval of Topical Ophthalmic Generic Products in the US – Simple to Complex Dosage Forms and Establishing Equivalency -- The development and commercialization of sustained-release ocular drug delivery technologies -- Manufacturing considerations and challenges for AAV Ocular Gene Therapy -- Transcorneal Kinetics of Topical Drugs and Nanoparticles.

This is a comprehensive textbook addressing the unique aspects of drug development for ophthalmic use. Beginning with a perspective on anatomy and physiology of the eye, the book provides a critical appraisal of principles that underlie ocular drug product development. The coverage encompasses topical and intraocular formulations, small molecules and biologics (including protein and gene therapies), conventional formulations (including solutions, suspensions, and emulsions), novel formulations (including nanoparticles, microparticles, and hydrogels), devices, and specialty products. Critical elements such as pharmacokinetics, influence of formulation technologies and ingredients, as well as impact of disease conditions on products development are addressed. Products intended for both the front and the back of the eye are discussed with an eye towards future advances.

ISBN: 9783030763671

Standard No.: 10.1007/978-3-030-76367-1doiSubjects--Topical Terms:

581965
Pharmaceutical chemistry.

LC Class. No.: RS400-431

Dewey Class. No.: 615.19

Ophthalmic Product Development = From Bench to Bedside /
LDR:04199nam a22004095i 4500 001 1059888
003 DE-He213
005 20220220172629.0
007 cr nn 008mamaa
008 220414s2021 sz | s |||| 0|eng d
020 $a 9783030763671 $9 978-3-030-76367-1
024 7 $a 10.1007/978-3-030-76367-1 $2 doi
035 $a 978-3-030-76367-1
050 4 $a RS400-431
072 7 $a PSB $2 bicssc
072 7 $a MED072000 $2 bisacsh
072 7 $a PNB $2 thema
082 0 4 $a 615.19 $2 23
245 1 0 $a Ophthalmic Product Development $h [electronic resource] : $b From Bench to Bedside / $c edited by Seshadri Neervannan, Uday B. Kompella.
250 $a 1st ed. 2021.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2021.
300 $a IX, 650 p. 126 illus., 105 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
490 1 $a AAPS Advances in the Pharmaceutical Sciences Series, $x 2210-738X ; $v 37
505 0 $a Introduction and History of Ophthalmic Product Development -- Ocular Surface Anatomy and Physiology: Impact on Product Development -- Anatomy and Physiology of the Anterior Chamber – Impact on Product Development -- Back of the eye anatomy & physiology – Impact on product development -- Physicochemical and Biological Fundamentals for Drug Delivery to the Eye -- Topical Ophthalmic Dosage Form Development – Key Components and Critical Quality Attributes -- Intra-ocular Injectable Dosage Form Development -- Microbiological Considerations for Ophthalmic Products – Sterility, Endotoxin Limits and Preservatives -- Packaging Development – Multi-dose container closure for preservative free products, extractable/leachables from packaging, new technologies -- Liquid ophthalmic drug products – physicochemical properties, formulations and manufacturing considerations -- Emulsions for topical eye delivery: state of the art and future perspectives -- Emulsions for topical eye delivery: state of the art and future perspectives -- Microparticle Products For The Eye - preformulation, formulation, and manufacturing considerations -- NANOPARTICLE PRODUCTS FOR THE EYE: preformulation, formulation and manufacturing considerations -- Advanced Hydrogel Formulations for the Eye -- Ophthalmic Product Development for Biologics -- Implantable Devices to Treat Ophthalmic Conditions –Drug Delivery Systems -- Development of Artificial Tears Products for Ocular Conditions -- Approval of Topical Ophthalmic Generic Products in the US – Simple to Complex Dosage Forms and Establishing Equivalency -- The development and commercialization of sustained-release ocular drug delivery technologies -- Manufacturing considerations and challenges for AAV Ocular Gene Therapy -- Transcorneal Kinetics of Topical Drugs and Nanoparticles.
520 $a This is a comprehensive textbook addressing the unique aspects of drug development for ophthalmic use. Beginning with a perspective on anatomy and physiology of the eye, the book provides a critical appraisal of principles that underlie ocular drug product development. The coverage encompasses topical and intraocular formulations, small molecules and biologics (including protein and gene therapies), conventional formulations (including solutions, suspensions, and emulsions), novel formulations (including nanoparticles, microparticles, and hydrogels), devices, and specialty products. Critical elements such as pharmacokinetics, influence of formulation technologies and ingredients, as well as impact of disease conditions on products development are addressed. Products intended for both the front and the back of the eye are discussed with an eye towards future advances.
650 0 $a Pharmaceutical chemistry. $3 581965
650 0 $a Ophthalmology. $3 644487
650 0 $a Drug delivery systems. $3 581921
650 0 $a Drugs—Design. $3 1366840
650 1 4 $a Pharmaceutics. $3 1366841
650 2 4 $a Drug Delivery. $3 1366630
650 2 4 $a Structure-Based Drug Design. $3 1366842
700 1 $a Neervannan, Seshadri. $e editor. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1366839
700 1 $a Kompella, Uday B. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 557402
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783030763664
776 0 8 $i Printed edition: $z 9783030763688
776 0 8 $i Printed edition: $z 9783030763695
830 0 $a AAPS Advances in the Pharmaceutical Sciences Series, $x 2210-7371 ; $v 20 $3 1255084
856 4 0 $u https://doi.org/10.1007/978-3-030-76367-1
912 $a ZDB-2-SBL
912 $a ZDB-2-SXB
950 $a Biomedical and Life Sciences (SpringerNature-11642)
950 $a Biomedical and Life Sciences (R0) (SpringerNature-43708)