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Investigation of Laser-Induced Phase-Separated Droplet of Aqueous Glycine Using Non-photochemical Laser-Induced Nucleation and Dynamic Light Scattering.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Investigation of Laser-Induced Phase-Separated Droplet of Aqueous Glycine Using Non-photochemical Laser-Induced Nucleation and Dynamic Light Scattering./
Author:	Gowayed, Omar.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
Description:	92 p.
Notes:	Source: Dissertations Abstracts International, Volume: 83-01, Section: B.
Contained By:	Dissertations Abstracts International83-01B.
Subject:	Materials science. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28498368
ISBN:	9798516929762

Investigation of Laser-Induced Phase-Separated Droplet of Aqueous Glycine Using Non-photochemical Laser-Induced Nucleation and Dynamic Light Scattering.
Gowayed, Omar.

Investigation of Laser-Induced Phase-Separated Droplet of Aqueous Glycine Using Non-photochemical Laser-Induced Nucleation and Dynamic Light Scattering. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 92 p.

Source: Dissertations Abstracts International, Volume: 83-01, Section: B.

Thesis (Ph.D.)--New York University Tandon School of Engineering, 2021.

This item must not be sold to any third party vendors.

Tightly focusing a continuous-wave, near-infrared laser beam at the air/solution interface of a mm-thick layer of glycine in D2O forms a crystal through a nucleation process known as gradient-force laser-induced nucleation. However, when this same beam is focused at the glass/solution interface of a film of aqueous glycine a laser-induced phase-separated (LIPS) solution droplet is formed instead. In addition to providing insight into the light-matter interactions of glycine nanodroplets in solution, the LIPS droplet has peculiar properties: it is visible beyond the focal region of the attracting beam, it has much higher glycine concentration than the surrounding solution, and it does not nucleate for as long the laser is focused at the glass/solution interface. In order to better understand the LIPS droplet, two optical experiments were conducted: (1) non-photochemical laser-induced nucleation (NPLIN) of a LIPS droplet using a single near-infrared (NIR) unfocused high-powered (0.4 GW/cm2) nanosecond laser pulse and (2) dynamic light scattering (DLS) of a LIPS droplet using a low-power continuous-wave (cw) blue laser beam (5 mW/cm2) and a modular, custom built, in-situ DLS apparatus.The NPLIN experiments revealed that NPLIN could nucleate crystals within a LIPS droplet and that the LIPS droplet was observed to be more labile to spontaneous nucleation than a control solution for the first 40 min of relaxation. The resulting crystals were analyzed using powder X-ray diffraction, and 100% of crystals formed within the LIPS droplet induced by NPLIN and by spontaneous nucleation were α-glycine. Additionally, the observation of nanodroplets in motion through DLS revealed that the application of optical tweezers at the glass/solution interface forms a relatively monodisperse collection of large nanodroplets (> 400 nm) concentrated around the focal point of the beam with smaller particles (< 100 nm) expelled from the LIPS droplet within the first two minutes of laser exposure. These experiments allow for a better understanding of the LIPS droplet and the interaction of optical tweezers with nanodroplets and nanoclusters in solution. This understanding will help in studying the fundamental nature of metastable nanodroplets. More practically, laser-induced phase-separation makes possible the nucleation-free separation of large nanodroplets from small clusters, facilitating materials technologies such as high purity, polymorphically selective nucleation of crystals and co-crystals used for pharmaceuticals, dyes, and photovoltaics.

ISBN: 9798516929762Subjects--Topical Terms:

557839
Materials science.
Subjects--Index Terms:

Crystallization

Investigation of Laser-Induced Phase-Separated Droplet of Aqueous Glycine Using Non-photochemical Laser-Induced Nucleation and Dynamic Light Scattering.
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245 1 0 $a Investigation of Laser-Induced Phase-Separated Droplet of Aqueous Glycine Using Non-photochemical Laser-Induced Nucleation and Dynamic Light Scattering.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2021
300 $a 92 p.
500 $a Source: Dissertations Abstracts International, Volume: 83-01, Section: B.
500 $a Advisor: Garetz, Bruce.
502 $a Thesis (Ph.D.)--New York University Tandon School of Engineering, 2021.
506 $a This item must not be sold to any third party vendors.
520 $a Tightly focusing a continuous-wave, near-infrared laser beam at the air/solution interface of a mm-thick layer of glycine in D2O forms a crystal through a nucleation process known as gradient-force laser-induced nucleation. However, when this same beam is focused at the glass/solution interface of a film of aqueous glycine a laser-induced phase-separated (LIPS) solution droplet is formed instead. In addition to providing insight into the light-matter interactions of glycine nanodroplets in solution, the LIPS droplet has peculiar properties: it is visible beyond the focal region of the attracting beam, it has much higher glycine concentration than the surrounding solution, and it does not nucleate for as long the laser is focused at the glass/solution interface. In order to better understand the LIPS droplet, two optical experiments were conducted: (1) non-photochemical laser-induced nucleation (NPLIN) of a LIPS droplet using a single near-infrared (NIR) unfocused high-powered (0.4 GW/cm2) nanosecond laser pulse and (2) dynamic light scattering (DLS) of a LIPS droplet using a low-power continuous-wave (cw) blue laser beam (5 mW/cm2) and a modular, custom built, in-situ DLS apparatus.The NPLIN experiments revealed that NPLIN could nucleate crystals within a LIPS droplet and that the LIPS droplet was observed to be more labile to spontaneous nucleation than a control solution for the first 40 min of relaxation. The resulting crystals were analyzed using powder X-ray diffraction, and 100% of crystals formed within the LIPS droplet induced by NPLIN and by spontaneous nucleation were α-glycine. Additionally, the observation of nanodroplets in motion through DLS revealed that the application of optical tweezers at the glass/solution interface forms a relatively monodisperse collection of large nanodroplets (> 400 nm) concentrated around the focal point of the beam with smaller particles (< 100 nm) expelled from the LIPS droplet within the first two minutes of laser exposure. These experiments allow for a better understanding of the LIPS droplet and the interaction of optical tweezers with nanodroplets and nanoclusters in solution. This understanding will help in studying the fundamental nature of metastable nanodroplets. More practically, laser-induced phase-separation makes possible the nucleation-free separation of large nanodroplets from small clusters, facilitating materials technologies such as high purity, polymorphically selective nucleation of crystals and co-crystals used for pharmaceuticals, dyes, and photovoltaics.
590 $a School code: 1988.
650 4 $a Materials science. $3 557839
650 4 $a Engineering. $3 561152
653 $a Crystallization
653 $a Crystals
653 $a Dynamic light scattering
653 $a Laser
653 $a Laser-induced phase-separation
653 $a Non-photochemical laser-induced nucleation
690 $a 0794
690 $a 0537
710 2 $a New York University Tandon School of Engineering. $b Chemical and Biological Engineering. $3 1372591
773 0 $t Dissertations Abstracts International $g 83-01B.
790 $a 1988
791 $a Ph.D.
792 $a 2021
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28498368