國立虎尾科技大學 |

The Genetic, Molecular, and Neuroendocrine Basis of Behavioral Evolution in Deer Mice.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	The Genetic, Molecular, and Neuroendocrine Basis of Behavioral Evolution in Deer Mice./
Author:	Niepoth, Natalie.
Description:	1 online resource (162 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-07, Section: B.
Contained By:	Dissertations Abstracts International85-07B.
Subject:	Genetics. -
Online resource:	click for full text (PQDT)
ISBN:	9798381381108

The Genetic, Molecular, and Neuroendocrine Basis of Behavioral Evolution in Deer Mice.
Niepoth, Natalie.

The Genetic, Molecular, and Neuroendocrine Basis of Behavioral Evolution in Deer Mice. - 1 online resource (162 pages)

Source: Dissertations Abstracts International, Volume: 85-07, Section: B.

Thesis (Ph.D.)--Columbia University, 2024.

Includes bibliographical references

Despite the extraordinary diversity of behavior across the animal kingdom, the genes and molecules that contribute to such natural diversity are largely unknown. In this thesis, I leverage the dramatic divergence in behavior between two closely related species of deer mice (genus Peromyscus) to investigate the genetic, cellular, and neuroendocrine basis of behavior. In chapter 2, I show that the monogamous oldfield mouse (Peromyscus polionotus subgriseus) has evolved a novel cell type in the adrenal gland that expresses the enzyme AKR1C18, which converts progesterone into 20α-hydroxyprogesterone (20α-OHP). I then demonstrate that 20α-OHP is more abundant in oldfield mice than in the closely-related promiscuous prairie deer mouse (P. maniculatus bairdii) and that it increases monogamous-typical parental behaviors when administered to both monogamous fathers. Using quantitative trait locus mapping in a cross between these species, I discover interspecific genetic variation that drives expression of the glycoprotein tenascin N and ultimately contributes to gain of adrenal AKR1C18 expression in oldfield mice. In chapter 3, I investigate the genetic architecture underlying the striking difference in exploratory behavior between prairie deer mice and oldfield mice. Through congenic fine-mapping, I identify a 15-Mb locus that strongly contributes to species differences in exploratory behavior. I then investigate the potential contributions of one of the 18 genes in the locus, Olfm4, which harbors cis-regulatory variants that drives its expression in the oldfield hypothalamus. Taken together, my research advances our understanding of the genetic and molecular causes that drive rapid behavioral divergence between species.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798381381108Subjects--Topical Terms:

578972
Genetics.
Subjects--Index Terms:

Animal kingdomIndex Terms--Genre/Form:

554714
Electronic books.

The Genetic, Molecular, and Neuroendocrine Basis of Behavioral Evolution in Deer Mice.
LDR:03123ntm a22003977 4500 001 1148785
005 20240930100147.5
006 m o d
007 cr bn ---uuuuu
008 250605s2024 xx obm 000 0 eng d
020 $a 9798381381108
035 $a (MiAaPQ)AAI30818789
035 $a AAI30818789
040 $a MiAaPQ $b eng $c MiAaPQ $d NTU
100 1 $a Niepoth, Natalie. $3 1474842
245 1 4 $a The Genetic, Molecular, and Neuroendocrine Basis of Behavioral Evolution in Deer Mice.
264 0 $c 2024
300 $a 1 online resource (162 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 85-07, Section: B.
500 $a Advisor: Bendesky, Andres.
502 $a Thesis (Ph.D.)--Columbia University, 2024.
504 $a Includes bibliographical references
520 $a Despite the extraordinary diversity of behavior across the animal kingdom, the genes and molecules that contribute to such natural diversity are largely unknown. In this thesis, I leverage the dramatic divergence in behavior between two closely related species of deer mice (genus Peromyscus) to investigate the genetic, cellular, and neuroendocrine basis of behavior. In chapter 2, I show that the monogamous oldfield mouse (Peromyscus polionotus subgriseus) has evolved a novel cell type in the adrenal gland that expresses the enzyme AKR1C18, which converts progesterone into 20α-hydroxyprogesterone (20α-OHP). I then demonstrate that 20α-OHP is more abundant in oldfield mice than in the closely-related promiscuous prairie deer mouse (P. maniculatus bairdii) and that it increases monogamous-typical parental behaviors when administered to both monogamous fathers. Using quantitative trait locus mapping in a cross between these species, I discover interspecific genetic variation that drives expression of the glycoprotein tenascin N and ultimately contributes to gain of adrenal AKR1C18 expression in oldfield mice. In chapter 3, I investigate the genetic architecture underlying the striking difference in exploratory behavior between prairie deer mice and oldfield mice. Through congenic fine-mapping, I identify a 15-Mb locus that strongly contributes to species differences in exploratory behavior. I then investigate the potential contributions of one of the 18 genes in the locus, Olfm4, which harbors cis-regulatory variants that drives its expression in the oldfield hypothalamus. Taken together, my research advances our understanding of the genetic and molecular causes that drive rapid behavioral divergence between species.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2024
538 $a Mode of access: World Wide Web
650 4 $a Genetics. $3 578972
650 4 $a Evolution & development. $3 1178838
650 4 $a Biology. $3 599573
653 $a Animal kingdom
653 $a Genetic architecture
653 $a AKR1C18 expression
653 $a Oldfield mice
653 $a Deer mice
655 7 $a Electronic books. $2 local $3 554714
690 $a 0369
690 $a 0412
690 $a 0306
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a Columbia University. $b Ecology, Evolution and Environmental Biology. $3 1474843
773 0 $t Dissertations Abstracts International $g 85-07B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30818789 $z click for full text (PQDT)