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Is Exercise-Induced Redox Signaling Affected by Aging?

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Is Exercise-Induced Redox Signaling Affected by Aging?/
Author:	Ostrom, Ethan L.
Description:	1 online resource (219 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 82-12, Section: B.
Contained By:	Dissertations Abstracts International82-12B.
Subject:	Biology. -
Online resource:	click for full text (PQDT)
ISBN:	9798738646928

Is Exercise-Induced Redox Signaling Affected by Aging?
Ostrom, Ethan L.

Is Exercise-Induced Redox Signaling Affected by Aging? - 1 online resource (219 pages)

Source: Dissertations Abstracts International, Volume: 82-12, Section: B.

Thesis (Ph.D.)--Northern Arizona University, 2021.

Includes bibliographical references

Redox signaling dysfunction is a key characteristic of aging cells and tissues and has wide ranging cellular and physiological effects. Exercise is one of the best tools available to promote healthy aging and reduce disease burden, however some evidence suggests exercise is not as effective in older populations. This is likely driven by redox signaling dysfunction because of the critical involvement of redox signaling mechanisms in exercise adaptations. In this work, I have used several studies in humans and mice with multiple methods to elucidate the mechanisms of Nrf2-mediated redox stress response to exercise and the effects of aging on this response. I demonstrate that exercise induced Nrf2 activation is impaired in older compared to younger adults, and that exercise training only partially reverses these effects. Redox stress responses to a non-exercise stressor, a forearm ischemia-reperfusion challenge, is not different between ages, but exercise training does improve the response compared to controls in humans. Finally, acute contractile stimulation of skeletal muscle increases Nrf2 signaling within the muscle, and high intensity stimulation activates Nrf2 in contralateral unstimulated muscle, but low intensity stimulation does not. These effects appear to occur through inhibiting the negative regulator, Keap1. Taken together, these data indicate that exercise is a powerful inducer of the redox stress response transcription factor, Nrf2, but that aging impairs our ability to respond to an acute exercise bout. Future work should aim to discover and utilize therapeutics that act synergistically with exercise to restore redox homeostasis and redox signaling function.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798738646928Subjects--Topical Terms:

599573
Biology.
Subjects--Index Terms:

AgingIndex Terms--Genre/Form:

554714
Electronic books.

Is Exercise-Induced Redox Signaling Affected by Aging?
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