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Neuroendocrine Control of Physiological, Behavioral, and Cellular Responses to Peroxides.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Neuroendocrine Control of Physiological, Behavioral, and Cellular Responses to Peroxides./
Author:	Schiffer, Jodie.
Description:	1 online resource (260 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 83-06, Section: B.
Contained By:	Dissertations Abstracts International83-06B.
Subject:	Genetics. -
Online resource:	click for full text (PQDT)
ISBN:	9798496538909

Neuroendocrine Control of Physiological, Behavioral, and Cellular Responses to Peroxides.
Schiffer, Jodie.

Neuroendocrine Control of Physiological, Behavioral, and Cellular Responses to Peroxides. - 1 online resource (260 pages)

Source: Dissertations Abstracts International, Volume: 83-06, Section: B.

Thesis (Ph.D.)--Northeastern University, 2021.

Includes bibliographical references

Wild C. elegans utilize sensory neurons to perceive the many environmental conditions and threats to which they are exposed. Under stressful conditions, these sensory neurons are responsible for initiating appropriate responses at the cellular, physiological, and behavioral levels. Of the many threats sensory neurons must detect, hydrogen peroxide is one of the most dangerous due to its prevalence as the main chemical weapon between species competing for resources. However, despite the persistent danger posed by environmental peroxides, hydrogen peroxide is also an important component of cell signaling and is required to regulate the function of thousands of proteins and many cellular processes. Thus, C. elegans must strike a careful balance between protecting itself from exogenous, lethal peroxides and interfering with vital cell signaling. We propose that C. elegans fine-tunes its response to peroxides by utilizing many levels of neuroendocrine control, from gene transcription, to behavior, to redox potential of the glutathione redox couple.Here, we describe how C. elegans uses a TGFβ-insulin/IGF1 hormonal relay from ASI sensory neurons to intestine to attempt to freeload off the hydrogen peroxide protection provided by bacteria in the environment and avoid altering its gene expression to mount its own hydrogen peroxide protection response. Further, we found that C. elegans can leave bacteria that cannot protect the animal from hydrogen peroxide in favor of finding bacteria that can, and that this behavior is driven by the different sets of sensory neurons that are excited in response to bacterial and hydrogen peroxide cues. We also explore how DAF-7/TGFβ signaling, a pathway regulated by environmental information, alters the redox potential of the glutathione redox couple to control the oxidation state of thousands of cytosolic proteins. Finally, we study how to protect redox potential measurements from changes in equipment. These studies shed new light on the nuance and care with which C. elegans, and likely other organisms, handle the balance between protecting themselves from lethal peroxides while maintaining the vital cell signaling regulated by hydrogen peroxide.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2024

Mode of access: World Wide Web

ISBN: 9798496538909Subjects--Topical Terms:

578972
Genetics.
Subjects--Index Terms:

BehaviorIndex Terms--Genre/Form:

554714
Electronic books.

Neuroendocrine Control of Physiological, Behavioral, and Cellular Responses to Peroxides.
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