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High Precision Fret to Study Bimolec...

Clemson University.

High Precision Fret to Study Bimolecular Dynamics with High Temporal Resolution.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	High Precision Fret to Study Bimolecular Dynamics with High Temporal Resolution./
Author:	Ma, Junyan.
Description:	1 online resource (110 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Contained By:	Dissertation Abstracts International79-10B(E).
Subject:	Chemistry. -
Online resource:	click for full text (PQDT)
ISBN:	9780438053533

High Precision Fret to Study Bimolecular Dynamics with High Temporal Resolution.
Ma, Junyan.

High Precision Fret to Study Bimolecular Dynamics with High Temporal Resolution. - 1 online resource (110 pages)

Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.

Thesis (Ph.D.)--Clemson University, 2018.

Includes bibliographical references

Forster Resonance Energy Transfer (FRET) is a promising methodology which is used by researchers in determining structural information of biomolecules. Other methodologies such as X-ray diffraction, nuclear magnetic resonance (NMR) and electron microscopy (EM), and X-ray scattering (SAXS) and circular dichroism (CD) can only give snapshots of the functional conformers. In the applications of most cases, FRET can only be used to give a qualitative result such as "yes" or "no" pattern. In our lab, we are able to expand this ability by applying FRET to quantitatively determine the structure and dynamic information in the biological system with high accuracy.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780438053533Subjects--Topical Terms:

593913
Chemistry.
Index Terms--Genre/Form:

554714
Electronic books.

High Precision Fret to Study Bimolecular Dynamics with High Temporal Resolution.
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100 1 $a Ma, Junyan. $3 1190216
245 1 0 $a High Precision Fret to Study Bimolecular Dynamics with High Temporal Resolution.
264 0 $c 2018
300 $a 1 online resource (110 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
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500 $a Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
500 $a Adviser: Hugo Sanabria.
502 $a Thesis (Ph.D.)--Clemson University, 2018.
504 $a Includes bibliographical references
520 $a Forster Resonance Energy Transfer (FRET) is a promising methodology which is used by researchers in determining structural information of biomolecules. Other methodologies such as X-ray diffraction, nuclear magnetic resonance (NMR) and electron microscopy (EM), and X-ray scattering (SAXS) and circular dichroism (CD) can only give snapshots of the functional conformers. In the applications of most cases, FRET can only be used to give a qualitative result such as "yes" or "no" pattern. In our lab, we are able to expand this ability by applying FRET to quantitatively determine the structure and dynamic information in the biological system with high accuracy.
520 $a We first apply this methodology in measuring our standard double strand DNA in order to identify its ability to obtain the interdye distance with high accuracy. Then, we are able to identify the fast dynamic which happens in mRNA followed by a kinetic pathway of its folding pattern. Finally, we used FRET as well as discrete molecular dynamics (DMD) simulation in determining dynamic behavior of PDZ domains.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Chemistry. $3 593913
655 7 $a Electronic books. $2 local $3 554714
690 $a 0485
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a Clemson University. $b Chemistry. $3 1190217
773 0 $t Dissertation Abstracts International $g 79-10B(E).
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10787217 $z click for full text (PQDT)

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