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From Acute Stress to Long-term Health : = the Role of Stress Systems Habituation and Basal Activities.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	From Acute Stress to Long-term Health :/
Reminder of title:	the Role of Stress Systems Habituation and Basal Activities.
Author:	Chen, Xuejie.
Description:	1 online resource (175 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 79-02(E), Section: B.
Contained By:	Dissertation Abstracts International79-02B(E).
Subject:	Psychobiology. -
Online resource:	click for full text (PQDT)
ISBN:	9780355435542

From Acute Stress to Long-term Health : = the Role of Stress Systems Habituation and Basal Activities.
Chen, Xuejie.

From Acute Stress to Long-term Health :the Role of Stress Systems Habituation and Basal Activities. - 1 online resource (175 pages)

Source: Dissertation Abstracts International, Volume: 79-02(E), Section: B.

Thesis (Ph.D.)--Brandeis University, 2017.

Includes bibliographical references

Psychological stress is prevailing in modern life and poses heavy health burdens. The detailed pathway of how stress effects on our health is still under investigation. Recently there has been increasing interest in exploring peripheral inflammation as the potential pathway, particularly considering that peripheral inflammation is reliably induced by psychological stress and has the ability to influence almost every organ in our body. The relationship between peripheral inflammation and later health outcomes has been established in several longitudinal studies. One question remaining is how acute stress reactivity exerts long-term effect on peripheral inflammation. In this dissertation, we specifically looked at two steps that were somehow less studied in current literature as the underlying pathways: 1) habituation of acute stress reactivity during repeated stress exposure; and 2) basal stress systems activities. To test this, we carried out 4 studies. In study 1, the reactivity of plasma cortisol (as the biomarker of Hypothalamus-pituitary-adrenal axis, HPA axis), salivary Interleukin-6 (IL-6, as the biomarker of peripheral inflammation) and pro- and anti- inflammatory gene expressions of acute stress as well as their habituation during repeated stress exposure were measured and their relationships with chronic stress were studied. We also assessed the moderating effect of cognitive appraisal on these relationships. We found that chronic stress was related to the reactivity and habituation of cortisol, inflammation and pro-and anti-inflammatory gene expressions to acute stress, and these relationships were moderated by cognitive appraisal. In study 2 and 3, we further tested whether differences in acute stress reactivity (both during initial exposure and in repeated settings) were associated with basal stress systems (HPA axis and sympathetic nervous system, SNS) activities. We found that the acute stress response patterns of cortisol, salivary alpha amylase (sAA, as the biomarker of SNS) and IL-6 were related with basal activities of both HPA axis and the SNS. The adaptive stress response patterns (e.g., adequate initial response and more habituation during repeated exposure) were related with basal activities that are usually found to be linked with healthier psychological and physiological status. In study 4, we tested whether the basal activity of SNS was related with peripheral inflammation. We found associations between basal amylase and peripheral inflammation, and we also found socioeconomic status (SES) moderated these relationships. Taken together, our findings suggested habituation of stress to repeated stress exposure and basal stress systems activities might be important steps that acute stress was related with peripheral inflammation and eventually, health outcomes.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355435542Subjects--Topical Terms:

655331
Psychobiology.
Index Terms--Genre/Form:

554714
Electronic books.

From Acute Stress to Long-term Health : = the Role of Stress Systems Habituation and Basal Activities.
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500 $a Source: Dissertation Abstracts International, Volume: 79-02(E), Section: B.
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504 $a Includes bibliographical references
520 $a Psychological stress is prevailing in modern life and poses heavy health burdens. The detailed pathway of how stress effects on our health is still under investigation. Recently there has been increasing interest in exploring peripheral inflammation as the potential pathway, particularly considering that peripheral inflammation is reliably induced by psychological stress and has the ability to influence almost every organ in our body. The relationship between peripheral inflammation and later health outcomes has been established in several longitudinal studies. One question remaining is how acute stress reactivity exerts long-term effect on peripheral inflammation. In this dissertation, we specifically looked at two steps that were somehow less studied in current literature as the underlying pathways: 1) habituation of acute stress reactivity during repeated stress exposure; and 2) basal stress systems activities. To test this, we carried out 4 studies. In study 1, the reactivity of plasma cortisol (as the biomarker of Hypothalamus-pituitary-adrenal axis, HPA axis), salivary Interleukin-6 (IL-6, as the biomarker of peripheral inflammation) and pro- and anti- inflammatory gene expressions of acute stress as well as their habituation during repeated stress exposure were measured and their relationships with chronic stress were studied. We also assessed the moderating effect of cognitive appraisal on these relationships. We found that chronic stress was related to the reactivity and habituation of cortisol, inflammation and pro-and anti-inflammatory gene expressions to acute stress, and these relationships were moderated by cognitive appraisal. In study 2 and 3, we further tested whether differences in acute stress reactivity (both during initial exposure and in repeated settings) were associated with basal stress systems (HPA axis and sympathetic nervous system, SNS) activities. We found that the acute stress response patterns of cortisol, salivary alpha amylase (sAA, as the biomarker of SNS) and IL-6 were related with basal activities of both HPA axis and the SNS. The adaptive stress response patterns (e.g., adequate initial response and more habituation during repeated exposure) were related with basal activities that are usually found to be linked with healthier psychological and physiological status. In study 4, we tested whether the basal activity of SNS was related with peripheral inflammation. We found associations between basal amylase and peripheral inflammation, and we also found socioeconomic status (SES) moderated these relationships. Taken together, our findings suggested habituation of stress to repeated stress exposure and basal stress systems activities might be important steps that acute stress was related with peripheral inflammation and eventually, health outcomes.
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538 $a Mode of access: World Wide Web
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650 4 $a Health sciences. $3 1179212
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