國立虎尾科技大學 |

Molecular theory of fluctuation in life phenomena

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Molecular theory of fluctuation in life phenomena/ by Fumio Hirata.
Author:	Hirata, Fumio.
Published:	Singapore :Springer Nature Singapore : : 2025.,
Description:	x, 146 p. :ill. (some col.), digital ; : 24 cm.;
Contained By:	Springer Nature eBook
Subject:	Molecular biology. -
Online resource:	https://doi.org/10.1007/978-981-96-3364-7
ISBN:	9789819633647

Molecular theory of fluctuation in life phenomena
Hirata, Fumio.

Molecular theory of fluctuation in life phenomena[electronic resource] /by Fumio Hirata. - Singapore :Springer Nature Singapore :2025. - x, 146 p. :ill. (some col.), digital ;24 cm.

Introduction -- Phenomenological description -- Statistical mechanics of molecular liquids -- Irreversible statistical mechanics of molecular liquids -- Conformational and density fluctuation in biomolecular system -- Chemical reactions of biomolecules in solutions -- Transitions among equilibrium states driven by fluctuations.

This book describes molecular processes taking place in living cells, in which "water" or "solvation" play essential roles. The molecular processes include conformational stability, fluctuation, relaxation, self-organization, molecular recognition, and chemical reactions. In all those processes, so-called solvation free-energy, and its first and second derivatives with respect to the atomic coordinates of biomolecules play key roles. Such derivatives of the free energy may not be calculated by any method of molecular simulation, because the calculation requires an analytical formula of the solvation free energy as a function of the atomic coordinates of a biomolecule. In this book, the theory is applied to analyze phenomena closely related to the conformational and density fluctuation of biomolecular systems, including the entropy and spectroscopy of both biomolecules and solvents. The theory is further developed to give microscopic expressions to the well-regarded phenomenological theories of chemical reactions, including the Michaelis-Menten theory of the enzymatic reaction, and the theory of the electron-transfer reaction by R. Marcus. Also clarified in the book is physical basis of Anfinsen's hypothesis concerning the protein folding. This book is beneficial for graduate students and researchers in the field of life science and technology, especially for those studying pharmaceutical design and biomimetic technology such as artificial enzymes.

ISBN: 9789819633647

Standard No.: 10.1007/978-981-96-3364-7doiSubjects--Topical Terms:

583443
Molecular biology.

LC Class. No.: QH506

Dewey Class. No.: 572.8

Molecular theory of fluctuation in life phenomena
LDR:02782nam a2200325 a 4500 001 1161714
003 DE-He213
005 20250424130217.0
006 m d
007 cr nn 008maaau
008 251029s2025 si s 0 eng d
020 $a 9789819633647 $q (electronic bk.)
020 $a 9789819633630 $q (paper)
024 7 $a 10.1007/978-981-96-3364-7 $2 doi
035 $a 978-981-96-3364-7
040 $a GP $c GP
041 0 $a eng
050 4 $a QH506
072 7 $a PNRP $2 bicssc
072 7 $a SCI013050 $2 bisacsh
072 7 $a PNRP $2 thema
082 0 4 $a 572.8 $2 23
090 $a QH506 $b .H668 2025
100 1 $a Hirata, Fumio. $3 894226
245 1 0 $a Molecular theory of fluctuation in life phenomena $h [electronic resource] / $c by Fumio Hirata.
260 $a Singapore : $c 2025. $b Springer Nature Singapore : $b Imprint: Springer,
300 $a x, 146 p. : $b ill. (some col.), digital ; $c 24 cm.
505 0 $a Introduction -- Phenomenological description -- Statistical mechanics of molecular liquids -- Irreversible statistical mechanics of molecular liquids -- Conformational and density fluctuation in biomolecular system -- Chemical reactions of biomolecules in solutions -- Transitions among equilibrium states driven by fluctuations.
520 $a This book describes molecular processes taking place in living cells, in which "water" or "solvation" play essential roles. The molecular processes include conformational stability, fluctuation, relaxation, self-organization, molecular recognition, and chemical reactions. In all those processes, so-called solvation free-energy, and its first and second derivatives with respect to the atomic coordinates of biomolecules play key roles. Such derivatives of the free energy may not be calculated by any method of molecular simulation, because the calculation requires an analytical formula of the solvation free energy as a function of the atomic coordinates of a biomolecule. In this book, the theory is applied to analyze phenomena closely related to the conformational and density fluctuation of biomolecular systems, including the entropy and spectroscopy of both biomolecules and solvents. The theory is further developed to give microscopic expressions to the well-regarded phenomenological theories of chemical reactions, including the Michaelis-Menten theory of the enzymatic reaction, and the theory of the electron-transfer reaction by R. Marcus. Also clarified in the book is physical basis of Anfinsen's hypothesis concerning the protein folding. This book is beneficial for graduate students and researchers in the field of life science and technology, especially for those studying pharmaceutical design and biomimetic technology such as artificial enzymes.
650 0 $a Molecular biology. $3 583443
650 0 $a Biomolecules. $3 683172
650 1 4 $a Theoretical Chemistry. $3 1387715
650 2 4 $a Biophysical Chemistry. $3 1392448
650 2 4 $a Molecular Biophysics. $3 1430063
650 2 4 $a Biophysical Methods. $3 1392449
650 2 4 $a Enzymology. $3 782178
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
856 4 0 $u https://doi.org/10.1007/978-981-96-3364-7
950 $a Chemistry and Materials Science (SpringerNature-11644)