Language:
English
繁體中文
Help
Login
Back
Switch To:
Labeled
|
MARC Mode
|
ISBD
Design of a Neural Prosthesis for Facial Reanimation and Assessment in a Rat Model
Record Type:
Language materials, printed : Monograph/item
Title/Author:
Design of a Neural Prosthesis for Facial Reanimation and Assessment in a Rat Model/ Nathan Jowett.
Author:
Jowett, Nathan,
Description:
1 electronic resource (228 pages)
Notes:
Source: Dissertations Abstracts International, Volume: 83-10, Section: B.
Contained By:
Dissertations Abstracts International83-10B.
Subject:
Computer aided design--CAD. -
Online resource:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29043387
ISBN:
9798209930945
Design of a Neural Prosthesis for Facial Reanimation and Assessment in a Rat Model
Jowett, Nathan,
Design of a Neural Prosthesis for Facial Reanimation and Assessment in a Rat Model
[electronic resource] /Nathan Jowett. - 1 electronic resource (228 pages)
Source: Dissertations Abstracts International, Volume: 83-10, Section: B.
Facial palsy is a devastating condition potentially amenable to rehabilitation by functional electrical stimulation. In the introduction, this thesis presents a general approach to the management of this disease state, its impact on patient quality of life, and limitations of current treatment modalities. In the body, this thesis characterizes new methods for high-throughput quantitative assessment of facial nerve structure and function in a rodent model. A novel paradigm for unilateral facial reanimation via an implantable neuroprosthetic device is then presented. The paradigm comprises use of healthy-side electromyography activity as control inputs to a system whose outputs are neural stimuli to effect symmetric facial displacements. The vexing issue of suppressing undesirable activity resulting from aberrant neural regeneration (i.e., synkinesis) or nerve transfer procedures is addressed using proximal neural blockade. The feasibility of this approach is demonstrated in a live rodent model via implantation of epimysial and nerve cuff electrode arrays. Stimuli were delivered to evoke blinks and whisks of various durations and amplitudes. The dynamic relation between electromyography signals and facial displacements were modelled, and model predictions compared against measured displacements. Optimal parameters to achieve facial nerve blockade by means of high-frequency alternating current were determined, and safety of continuous delivery assessed over the medium term. Electrode implantation was well tolerated. Blinks and whisks of tunable amplitudes and durations were evoked by controlled variation of neural stimuli parameters. Facial displacements predicted from electromyography input modelling matched those observed with a variance accounted for exceeding 96%. Effective and reversible facial nerve blockade in awake behaving animals was achieved, without detrimental effects noted from continual use over several weeks. The use of proximal neural blockade coupled with distal functional electrical stimulation for the rehabilitation of other peripheral motor nerve deficits is discussed, together with potential pathways for clinical translation.
English
ISBN: 9798209930945Subjects--Topical Terms:
1372801
Computer aided design--CAD.
Design of a Neural Prosthesis for Facial Reanimation and Assessment in a Rat Model
LDR
:06414nam a22005053i 4500
001
1172852
005
20260622113216.5
006
m o d
007
cr|nu||||||||
008
260803s2021 miu||||||m |||||||eng d
020
$a
9798209930945
035
$a
(MiAaPQD)AAI29043387
035
$a
(MiAaPQD)McGill_4j03d463t
035
$a
AAI29043387
040
$a
MiAaPQD
$b
eng
$c
MiAaPQD
$e
rda
100
1
$a
Jowett, Nathan,
$e
author.
$3
1503461
245
1 0
$a
Design of a Neural Prosthesis for Facial Reanimation and Assessment in a Rat Model
$c
Nathan Jowett.
$h
[electronic resource] /
264
1
$a
Ann Arbor :
$b
ProQuest Dissertations & Theses,
$c
2021
300
$a
1 electronic resource (228 pages)
336
$a
text
$b
txt
$2
rdacontent
337
$a
computer
$b
c
$2
rdamedia
338
$a
online resource
$b
cr
$2
rdacarrier
500
$a
Source: Dissertations Abstracts International, Volume: 83-10, Section: B.
500
$a
Advisors: Kearney, Robert E.; Hadlock, Tessa A.
502
$b
Ph.D.
$c
McGill University (Canada)
$d
2021.
520
#
$a
Facial palsy is a devastating condition potentially amenable to rehabilitation by functional electrical stimulation. In the introduction, this thesis presents a general approach to the management of this disease state, its impact on patient quality of life, and limitations of current treatment modalities. In the body, this thesis characterizes new methods for high-throughput quantitative assessment of facial nerve structure and function in a rodent model. A novel paradigm for unilateral facial reanimation via an implantable neuroprosthetic device is then presented. The paradigm comprises use of healthy-side electromyography activity as control inputs to a system whose outputs are neural stimuli to effect symmetric facial displacements. The vexing issue of suppressing undesirable activity resulting from aberrant neural regeneration (i.e., synkinesis) or nerve transfer procedures is addressed using proximal neural blockade. The feasibility of this approach is demonstrated in a live rodent model via implantation of epimysial and nerve cuff electrode arrays. Stimuli were delivered to evoke blinks and whisks of various durations and amplitudes. The dynamic relation between electromyography signals and facial displacements were modelled, and model predictions compared against measured displacements. Optimal parameters to achieve facial nerve blockade by means of high-frequency alternating current were determined, and safety of continuous delivery assessed over the medium term. Electrode implantation was well tolerated. Blinks and whisks of tunable amplitudes and durations were evoked by controlled variation of neural stimuli parameters. Facial displacements predicted from electromyography input modelling matched those observed with a variance accounted for exceeding 96%. Effective and reversible facial nerve blockade in awake behaving animals was achieved, without detrimental effects noted from continual use over several weeks. The use of proximal neural blockade coupled with distal functional electrical stimulation for the rehabilitation of other peripheral motor nerve deficits is discussed, together with potential pathways for clinical translation.
520
3
$a
La paralysie faciale est une condition dévastatrice potentiellement susceptible de rééducation par stimulation électrique fonctionnelle. En introduction, cette thèse présente une approche générale de la prise en charge de cet état pathologique, de son impact sur la qualité de vie des patients et des limites des modalités de traitement actuelles. Dans le corps, cette thèse caractérise de nouvelles méthodes d'évaluation à haut débit et quantitatives supérieures de la structure et de la fonction du nerf facial dans un modèle de rongeur. Un nouveau paradigme de réanimation faciale unilatérale via un dispositif neuroprothétique implantable est ensuite présenté. Le paradigme comprend l'utilisation de l'activité d'électromyographie du côté sain comme entrées de contrôle dans un système dont les sorties sont des stimuli neuronal pour effectuer des déplacements faciaux symétriques. Le problème épineux de la suppression de l'activité indésirable résultant de la régénération neurale aberrante (c'est à dire la syncinésie) ou des procédures de transfert de nerf est abordé en utilisant le blocage neural proximal. La faisabilité de cette approche est démontrée dans un modèle de rongeur vivant via l'implantation de réseaux d'électrodes épimysiales et nerveuses. Des stimuli ont été délivrés pour évoquer des clignements et des fouets de différentes durées et amplitudes. La relation dynamique entre les signaux d'électromyographie et les déplacements faciaux a été modélisée et les prédictions du modèle comparées aux déplacements mesurés. Les paramètres optimaux pour obtenir un blocage du nerf facial au moyen d'un courant alternatif à haute fréquence ont été déterminés, et la sécurité de l'administration continue évaluée à moyen terme. L'implantation d'électrodes a été bien tolérée. Des clignements et des battements d'amplitudes et de durées réglables ont été évoqués par une variation contrôlée des paramètres des stimuli neuronaux. Les déplacements faciaux prédits à partir de la modélisation des entrées d'électromyographie correspondaient à ceux observés avec une variance expliquée dépassant 96%. Un blocage efficace et réversible du nerf facial chez des animaux éveillés a été obtenu, sans effet néfaste noté par une utilisation continue pendant plusieurs semaines. L'utilisation du blocage neural proximal couplé à une stimulation électrique fonctionnelle distale pour la réhabilitation d'autres déficits du nerf moteur périphérique est discutée, ainsi que des voies potentielles pour la traduction clinique.
546
$a
English
590
$a
School code: 0781
650
# 4
$a
Computer aided design--CAD.
$3
1372801
650
# 4
$a
Computer vision.
$3
561800
650
# 4
$a
Knowledge discovery.
$3
1503465
650
# 4
$a
Antibodies.
$3
782661
650
# 4
$a
Otolaryngology.
$3
792371
650
# 4
$a
Optics.
$3
595336
650
# 4
$a
Medicine.
$3
644133
650
# 4
$a
Engineering.
$3
561152
650
# 4
$a
Electrical engineering.
$3
596380
650
# 4
$a
Computer science.
$3
573171
650
# 4
$a
Chemistry.
$3
593913
650
# 4
$a
Analytical chemistry.
$3
1182118
650
# 4
$a
Design.
$3
595500
650
# 4
$a
Medical research.
$2
bicssc
$3
809476
650
# 4
$a
Neural networks.
$3
1011215
650
# 4
$a
Sleep apnea.
$3
1503464
650
# 4
$a
Neurological disorders.
$3
1467232
650
# 4
$a
Power.
$3
999190
650
# 4
$a
Surgery.
$3
644132
650
# 4
$a
Spectrum analysis.
$3
582358
650
# 4
$a
Control algorithms.
$3
1372652
650
# 4
$a
Integrated circuits.
$3
561474
650
# 4
$a
Patients.
$3
963142
650
# 4
$a
Chicken pox.
$3
1503463
650
# 4
$a
Electromyography.
$3
645656
650
# 4
$a
Neurosciences.
$3
593561
650
# 4
$a
Life sciences.
$3
815602
650
# 4
$a
Electrodes.
$3
581312
650
# 4
$a
Transplants & implants.
$3
1372539
650
# 4
$a
Airway management.
$3
1503462
690
$a
0389
690
$a
0800
690
$a
0576
690
$a
0317
690
$a
0486
690
$a
0485
690
$a
0984
690
$a
0544
690
$a
0537
690
$a
0564
690
$a
0752
710
2 #
$a
McGill University (Canada).
$3
845629
720
1
$a
Kearney, Robert E.
$e
degree supervisor.
720
1
$a
Hadlock, Tessa A.
$e
degree supervisor.
773
0 #
$t
Dissertations Abstracts International
$g
83-10B.
790
$a
0781
791
$a
Ph.D.
792
$a
2021
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29043387
based on 0 review(s)
Multimedia
Reviews
Add a review
and share your thoughts with other readers
Export
pickup library
Processing
...
Change password
Login