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Eosinophils in Chronic Obstructive Pulmonary Disease (COPD)

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Eosinophils in Chronic Obstructive Pulmonary Disease (COPD)/ Augusta S Beech.
Author:	Beech, Augusta S,
Description:	1 electronic resource (348 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 86-04, Section: B.
Contained By:	Dissertations Abstracts International86-04B.
Subject:	Medicine. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31596448
ISBN:	9798342126694

Eosinophils in Chronic Obstructive Pulmonary Disease (COPD)
Beech, Augusta S,

Eosinophils in Chronic Obstructive Pulmonary Disease (COPD) [electronic resource] /Augusta S Beech. - 1 electronic resource (348 pages)

Source: Dissertations Abstracts International, Volume: 86-04, Section: B.

Background:Higher sputum and blood eosinophil counts (BEC) are associated with a greater clinical response to corticosteroids. The stability of BEC in COPD remains a controversial topic, and the stability of pulmonary eosinophil counts has yet to be fully elucidated. Before the start of this thesis, it was known that sputum eosinophil counts were inversely associated with bacterial colonisation of the airways, but species-specific interactions were not known. I aimed to define COPD subgroups based on phenotypic and endotype-related information, including: 1) eosinophil counts and 2) respiratory microbiome characteristics, in stable state disease. Methodological issues such as stability of measurements and threshold criteria for defining bacterial airway colonisation in COPD were investigated.Methods:1) The prevalence and temporal stability of eosinophils were assessed using blood, sputum and resected lung tissue from COPD patients. Clinical characteristics were assessed in relation to eosinophil counts. Small airway eosinophil counts were compared between COPD patients and controls, moreover the spatial stability of counts were assessed and2) Bacterial airway colonisation was assessed using qPCR in COPD and healthy individuals.Results: 1) Higher pulmonary eosinophil counts were evident in a subgroup of COPD patients and exhibited greater temporal and spatial variability throughout the bronchial tree, whilst lower counts were more stable and associated with active smoking and 2) Eosinophilic inflammation was rarely observed alongside Haemophilus influenzaecolonisation of the airway, using species-specific thresholds for bacterial colonisation defined based on a group of healthy individuals to demonstrate this relationship.Conclusions:These findings further characterise pulmonary eosinophilic inflammation and the associated respiratory microbiome in COPD. Thresholds for bacterial colonisation of the airway should be defined based on a healthy population. The variability of disease characteristics such as eosinophilic inflammation is dependent on the magnitude.

English

ISBN: 9798342126694Subjects--Topical Terms:

644133
Medicine.

Eosinophils in Chronic Obstructive Pulmonary Disease (COPD)
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520 # $a Background:Higher sputum and blood eosinophil counts (BEC) are associated with a greater clinical response to corticosteroids. The stability of BEC in COPD remains a controversial topic, and the stability of pulmonary eosinophil counts has yet to be fully elucidated. Before the start of this thesis, it was known that sputum eosinophil counts were inversely associated with bacterial colonisation of the airways, but species-specific interactions were not known. I aimed to define COPD subgroups based on phenotypic and endotype-related information, including: 1) eosinophil counts and 2) respiratory microbiome characteristics, in stable state disease. Methodological issues such as stability of measurements and threshold criteria for defining bacterial airway colonisation in COPD were investigated.Methods:1) The prevalence and temporal stability of eosinophils were assessed using blood, sputum and resected lung tissue from COPD patients. Clinical characteristics were assessed in relation to eosinophil counts. Small airway eosinophil counts were compared between COPD patients and controls, moreover the spatial stability of counts were assessed and2) Bacterial airway colonisation was assessed using qPCR in COPD and healthy individuals.Results: 1) Higher pulmonary eosinophil counts were evident in a subgroup of COPD patients and exhibited greater temporal and spatial variability throughout the bronchial tree, whilst lower counts were more stable and associated with active smoking and 2) Eosinophilic inflammation was rarely observed alongside Haemophilus influenzaecolonisation of the airway, using species-specific thresholds for bacterial colonisation defined based on a group of healthy individuals to demonstrate this relationship.Conclusions:These findings further characterise pulmonary eosinophilic inflammation and the associated respiratory microbiome in COPD. Thresholds for bacterial colonisation of the airway should be defined based on a healthy population. The variability of disease characteristics such as eosinophilic inflammation is dependent on the magnitude.
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