國立虎尾科技大學 |

Nuclear receptors = from structure to the clinic /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Nuclear receptors/ edited by Iain J. McEwan, Raj Kumar.
Reminder of title:	from structure to the clinic /
other author:	McEwan, I. J.
Published:	Cham :Springer International Publishing : : 2015.,
Description:	xi, 236 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
Subject:	Nuclear receptors (Biochemistry) - Handbooks, manuals, etc. -
Online resource:	http://dx.doi.org/10.1007/978-3-319-18729-7
ISBN:	9783319187297

Nuclear receptors = from structure to the clinic /
Nuclear receptorsfrom structure to the clinic /[electronic resource] :edited by Iain J. McEwan, Raj Kumar. - Cham :Springer International Publishing :2015. - xi, 236 p. :ill., digital ;24 cm.

1. Twenty-five Years of Nuclear Receptor Structure Analysis: From the Laboratory to the Clinic -- Part A. ALLOSTERIC REGULATION AND NUCLEAR RECEPTOR COMPLEX DYNAMICS. -2. Corticosteroid Receptors -- 3. Glucocorticoid Receptor Structure and Function -- 4. What Determines the Difference in DNA Binding Between the Androgen and the Glucocorticoid Receptors? -- 5. Allosteric Regulation and Intrinsic Disorder in Nuclear Hormone Receptors -- 6. Structural Analyses of Ordered and Disordered Regions in Ecdysteroid Receptor -- 7. Structural Analysis of Heterodimeric Nuclear Receptors -- Part B. NUCLEAR RECEPTOR CO-REGULATORY PROTEIN INTERACTIONS -- 8. Primate-specific Multi-functional Androgen Receptor Coregulator and Proto-oncogene Melanoma Antigen-A11 (MAGE-A11) -- 9. Assembly and Regulation of Nuclear Receptor Corepressor Complexes -- Part C. TAKING NUCLEAR RECEPTOR STRUCTURE INTO THE CLINIC -- 10. Thinking Outside the Box: Alternative Binding Sites in the Ligand Binding Domain of Nuclear Receptors -- 11. Selective Estrogen Receptor Modulators (SERMs) and Selective Androgen Receptor Modulators (SARMs)

Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. The aim is to bring together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity. The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.

ISBN: 9783319187297

Standard No.: 10.1007/978-3-319-18729-7doiSubjects--Topical Terms:

788536
Nuclear receptors (Biochemistry)
--Handbooks, manuals, etc.

LC Class. No.: QH603.C43 / M34 2015

Dewey Class. No.: 572.696

Nuclear receptors = from structure to the clinic /
LDR:03508nam a2200313 a 4500 001 837061
003 DE-He213
005 20160302135721.0
006 m d
007 cr nn 008maaau
008 160421s2015 gw s 0 eng d
020 $a 9783319187297 $q (electronic bk.)
020 $a 9783319187280 $q (paper)
024 7 $a 10.1007/978-3-319-18729-7 $2 doi
035 $a 978-3-319-18729-7
040 $a GP $c GP
041 0 $a eng
050 4 $a QH603.C43 $b M34 2015
072 7 $a MFN $2 bicssc
072 7 $a MED107000 $2 bisacsh
082 0 4 $a 572.696 $2 23
090 $a QH603.C43 $b N964 2015
245 0 0 $a Nuclear receptors $h [electronic resource] : $b from structure to the clinic / $c edited by Iain J. McEwan, Raj Kumar.
260 $a Cham : $c 2015. $b Springer International Publishing : $b Imprint: Springer,
300 $a xi, 236 p. : $b ill., digital ; $c 24 cm.
505 0 $a 1. Twenty-five Years of Nuclear Receptor Structure Analysis: From the Laboratory to the Clinic -- Part A. ALLOSTERIC REGULATION AND NUCLEAR RECEPTOR COMPLEX DYNAMICS. -2. Corticosteroid Receptors -- 3. Glucocorticoid Receptor Structure and Function -- 4. What Determines the Difference in DNA Binding Between the Androgen and the Glucocorticoid Receptors? -- 5. Allosteric Regulation and Intrinsic Disorder in Nuclear Hormone Receptors -- 6. Structural Analyses of Ordered and Disordered Regions in Ecdysteroid Receptor -- 7. Structural Analysis of Heterodimeric Nuclear Receptors -- Part B. NUCLEAR RECEPTOR CO-REGULATORY PROTEIN INTERACTIONS -- 8. Primate-specific Multi-functional Androgen Receptor Coregulator and Proto-oncogene Melanoma Antigen-A11 (MAGE-A11) -- 9. Assembly and Regulation of Nuclear Receptor Corepressor Complexes -- Part C. TAKING NUCLEAR RECEPTOR STRUCTURE INTO THE CLINIC -- 10. Thinking Outside the Box: Alternative Binding Sites in the Ligand Binding Domain of Nuclear Receptors -- 11. Selective Estrogen Receptor Modulators (SERMs) and Selective Androgen Receptor Modulators (SARMs)
520 $a Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. The aim is to bring together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity. The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.
650 0 $a Nuclear receptors (Biochemistry) $v Handbooks, manuals, etc. $3 788536
650 0 $a Human genome. $3 566752
650 1 4 $a Biomedicine. $3 593880
650 2 4 $a Human Genetics. $3 593893
650 2 4 $a Endocrinology. $3 645497
650 2 4 $a Human Physiology. $3 668349
700 1 $a McEwan, I. J. $3 1067652
700 1 $a Kumar, Raj. $3 1067653
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-18729-7
950 $a Biomedical and Life Sciences (Springer-11642)