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Crystals, X-rays, and proteins : = c...

Cooper, Jon

Crystals, X-rays, and proteins : = comprehensive protein crystallography /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Crystals, X-rays, and proteins :/ Dennis Sherwood, Jon Cooper.
Reminder of title:	comprehensive protein crystallography /
Author:	Sherwood, Dennis,
other author:	Cooper, Jon
Published:	Oxford, United Kingdom ;Oxford University Press, : 2015.,
Description:	xvii, 625 p. :ill. ; : 25 cm.;
Subject:	Proteins - Structure. -
ISBN:	9780198726326 (pbk.) :

Crystals, X-rays, and proteins : = comprehensive protein crystallography /
Sherwood, Dennis,

Crystals, X-rays, and proteins :comprehensive protein crystallography /Dennis Sherwood, Jon Cooper. - Pbk. ed. - Oxford, United Kingdom ;Oxford University Press,2015. - xvii, 625 p. :ill. ;25 cm.

Includes bibliographical references (p. [616]-620) and index.

Machine generated contents note: -- 1. The crystalline state and its study -- 2. Vector analysis and complex algebra -- 3. Crystal systematics -- 4. Waves and electromagnetic radiation -- 5. Fourier transforms and convolutions -- 6. Diffraction --7. Diffraction from one-dimensional obstacles -- 8. Diffraction from a three-dimensional lattice -- 9. The contents of the unit cell -- 10. Experimental methods : sample preparation -- 11. Experimental techniques : data collection and analysis -- 12. The phase problem and the Patterson function --13. Molecular replacement -- 14. Solving the phase problem experimentally -- 15. Model building and refinement -- 16. Complementary crystallographic methods.

"A complete account of the theory of the diffraction of x-rays by crystals with particular reference to the processes of determining the structures of protein molecules, this book is aimed primarily at structural biologists and biochemists but will also be valuable to those entering the field with a background in physical sciences or chemistry. It may be used at any post-school level, and develops from first principles all relevant mathematics, diffraction and wave theory, assuming no mathematical knowledge beyond integral calculus. The book covers a host of important topics in the area, including:- The practical aspects of sample preparation and x-ray data collection, using both laboratory and synchrotron sources - Data analysis at both theoretical and practical levels- The important role played by the Patterson function in structure analysis by both molecular replacement and experimental phasing approaches - Methods for improving the resulting electron density map - The theoretical basis of methods used in refinement of protein crystal structures - In-depth explanation of the crucial task of defining the binding sites of ligands and drug molecules - The complementary roles of other diffraction methods which reveal further detail of great functional importance in a crystal structure"--

ISBN: 9780198726326 (pbk.) :NT1681

LCCN: 2015413332Subjects--Topical Terms:

582869
Proteins
--Structure.

LC Class. No.: QP551 / .S535 2015

Dewey Class. No.: 572/.6

Crystals, X-rays, and proteins : = comprehensive protein crystallography /
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008 160922s2015 enka b 001 0 eng
010 $a 2015413332
020 $a 9780198726326 (pbk.) : $c NT1681
020 $a 9780199559046 (cloth)
035 $a 18723488
040 $a DLC $b eng $c NFU $d DLC
041 0 # $a eng
042 $a pcc
050 0 0 $a QP551 $b .S535 2015
082 0 0 $a 572/.6 $2 23
100 1 $a Sherwood, Dennis, $e author. $3 1080582
245 1 0 $a Crystals, X-rays, and proteins : $b comprehensive protein crystallography / $c Dennis Sherwood, Jon Cooper.
250 $a Pbk. ed.
260 # $a Oxford, United Kingdom ; $a New York, NY : $b Oxford University Press, $c 2015.
300 $a xvii, 625 p. : $b ill. ; $c 25 cm.
504 $a Includes bibliographical references (p. [616]-620) and index.
505 8 # $a Machine generated contents note: -- 1. The crystalline state and its study -- 2. Vector analysis and complex algebra -- 3. Crystal systematics -- 4. Waves and electromagnetic radiation -- 5. Fourier transforms and convolutions -- 6. Diffraction --7. Diffraction from one-dimensional obstacles -- 8. Diffraction from a three-dimensional lattice -- 9. The contents of the unit cell -- 10. Experimental methods : sample preparation -- 11. Experimental techniques : data collection and analysis -- 12. The phase problem and the Patterson function --13. Molecular replacement -- 14. Solving the phase problem experimentally -- 15. Model building and refinement -- 16. Complementary crystallographic methods.
520 # $a "A complete account of the theory of the diffraction of x-rays by crystals with particular reference to the processes of determining the structures of protein molecules, this book is aimed primarily at structural biologists and biochemists but will also be valuable to those entering the field with a background in physical sciences or chemistry. It may be used at any post-school level, and develops from first principles all relevant mathematics, diffraction and wave theory, assuming no mathematical knowledge beyond integral calculus. The book covers a host of important topics in the area, including:- The practical aspects of sample preparation and x-ray data collection, using both laboratory and synchrotron sources - Data analysis at both theoretical and practical levels- The important role played by the Patterson function in structure analysis by both molecular replacement and experimental phasing approaches - Methods for improving the resulting electron density map - The theoretical basis of methods used in refinement of protein crystal structures - In-depth explanation of the crucial task of defining the binding sites of ligands and drug molecules - The complementary roles of other diffraction methods which reveal further detail of great functional importance in a crystal structure"-- $c Provided by publisher.
650 # 0 $a Proteins $x Structure. $3 582869
650 # 0 $a X-ray crystallography. $3 673202
700 1 # $a Cooper, Jon $q (Jonathan B.) $3 870671