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Biomarkers of Early Alzheimer's Disease and Attentional Control Performance in Cognitively Asymptomatic Older Adults.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	Biomarkers of Early Alzheimer's Disease and Attentional Control Performance in Cognitively Asymptomatic Older Adults./
Author:	Van Patten, Ryan.
Description:	1 online resource (105 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 79-03(E), Section: B.
Subject:	Cognitive psychology. -
Online resource:	click for full text (PQDT)
ISBN:	9780355349313

Biomarkers of Early Alzheimer's Disease and Attentional Control Performance in Cognitively Asymptomatic Older Adults.
Van Patten, Ryan.

Biomarkers of Early Alzheimer's Disease and Attentional Control Performance in Cognitively Asymptomatic Older Adults. - 1 online resource (105 pages)

Source: Dissertation Abstracts International, Volume: 79-03(E), Section: B.

Thesis (Ph.D.)--Saint Louis University, 2018.

Includes bibliographical references

The prevalence of Alzheimer's disease (AD) is increasing rapidly on a global scale. In response, substantive efforts are being made to advance the early detection of AD. Much attention is being paid to biomarkers of AD progression and mitigators of AD pathology such as cognitive reserve. In addition, reflections of attentional control such as performance on the Stroop task have shown sensitivity to preclinical AD. Adding the event-related potential (ERP) methodology to behavioral Stroop data allows for concurrent observation of covert neural processing during task performance. Integrating these parallel lines of research, the current study aimed to demonstrate relationships among AD biomarkers (A?42 and the CSF p-tau/A?42 ratio) and behavioral and electrophysiological correlates in a sample of cognitively asymptomatic older adults. Specifically, data were analyzed from 29 older adults, aged 60-89, who completed a computerized, cued-Stroop task while ERPs (i.e., the N450 and conflict SP) were recorded and relevant demographic and biomarker data (i.e., cerebrospinal fluid beta amyloid and tau) were acquired. It was hypothesized that: a) attentional control deficits would be evident in individuals with biomarkers of preclinical AD, that b) biomarkers of AD would predict behavioral and electrophysiological correlates of attentional control above and beyond demographic factors, and that c) cognitive reserve would buffer against biomarker-measured AD neuropathology. Results supported the sensitivity of intraindividual variability in Stroop RTs and the conflict-response N450 ERP component to early AD. In contrast, predictions pertaining to Stroop accuracy rates, the conflict SP, and the mitigating effect of cognitive reserve were not supported. Overall, in the context of preclinical AD, these findings have implications for early detection of AD and for the development of novel biomarkers with utility above and beyond available methods.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355349313Subjects--Topical Terms:

556029
Cognitive psychology.
Index Terms--Genre/Form:

554714
Electronic books.

Biomarkers of Early Alzheimer's Disease and Attentional Control Performance in Cognitively Asymptomatic Older Adults.
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520 $a The prevalence of Alzheimer's disease (AD) is increasing rapidly on a global scale. In response, substantive efforts are being made to advance the early detection of AD. Much attention is being paid to biomarkers of AD progression and mitigators of AD pathology such as cognitive reserve. In addition, reflections of attentional control such as performance on the Stroop task have shown sensitivity to preclinical AD. Adding the event-related potential (ERP) methodology to behavioral Stroop data allows for concurrent observation of covert neural processing during task performance. Integrating these parallel lines of research, the current study aimed to demonstrate relationships among AD biomarkers (A?42 and the CSF p-tau/A?42 ratio) and behavioral and electrophysiological correlates in a sample of cognitively asymptomatic older adults. Specifically, data were analyzed from 29 older adults, aged 60-89, who completed a computerized, cued-Stroop task while ERPs (i.e., the N450 and conflict SP) were recorded and relevant demographic and biomarker data (i.e., cerebrospinal fluid beta amyloid and tau) were acquired. It was hypothesized that: a) attentional control deficits would be evident in individuals with biomarkers of preclinical AD, that b) biomarkers of AD would predict behavioral and electrophysiological correlates of attentional control above and beyond demographic factors, and that c) cognitive reserve would buffer against biomarker-measured AD neuropathology. Results supported the sensitivity of intraindividual variability in Stroop RTs and the conflict-response N450 ERP component to early AD. In contrast, predictions pertaining to Stroop accuracy rates, the conflict SP, and the mitigating effect of cognitive reserve were not supported. Overall, in the context of preclinical AD, these findings have implications for early detection of AD and for the development of novel biomarkers with utility above and beyond available methods.
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