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The Exuberant Vine of Epitranscriptome : = RNA Methylation as a New Epigenetic Regulatory Mechanism.

Record Type:	Language materials, manuscript : Monograph/item
Title/Author:	The Exuberant Vine of Epitranscriptome :/
Reminder of title:	RNA Methylation as a New Epigenetic Regulatory Mechanism.
Author:	Zhao, Boxuan.
Description:	1 online resource (186 pages)
Notes:	Source: Dissertation Abstracts International, Volume: 79-01(E), Section: B.
Contained By:	Dissertation Abstracts International79-01B(E).
Subject:	Biochemistry. -
Online resource:	click for full text (PQDT)
ISBN:	9780355234893

The Exuberant Vine of Epitranscriptome : = RNA Methylation as a New Epigenetic Regulatory Mechanism.
Zhao, Boxuan.

The Exuberant Vine of Epitranscriptome :RNA Methylation as a New Epigenetic Regulatory Mechanism. - 1 online resource (186 pages)

Source: Dissertation Abstracts International, Volume: 79-01(E), Section: B.

Thesis (Ph.D.)--The University of Chicago, 2017.

Includes bibliographical references

Nucleic acids, one of the most essential biological macromolecules, store and transfer genetic information of all living organisms. They comprise of four canonical units: A, T, C, and G for DNA, and A, U, C, and G for RNA. Some of these units are chemically modified to record an extra dimension of information on top of the primary sequence. The existence of these modifications has been known for decades, yet the regulation and the functions of them remained largely elusive. My doctoral work is focused on the most prevalent chemical modification on human messenger RNA, N6-methyladenosine (m6A). Understanding the regulatory mechanism and cognate functions of m6A in various biological events is crucial for the clarification of how cells encode epigenetic information into chemical modifications for global gene regulation. The characterization of m6A metabolism may also provide valuable implications for the studies of complex biological processes and human diseases.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2018

Mode of access: World Wide Web

ISBN: 9780355234893Subjects--Topical Terms:

582831
Biochemistry.
Index Terms--Genre/Form:

554714
Electronic books.

The Exuberant Vine of Epitranscriptome : = RNA Methylation as a New Epigenetic Regulatory Mechanism.
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245 1 4 $a The Exuberant Vine of Epitranscriptome : $b RNA Methylation as a New Epigenetic Regulatory Mechanism.
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300 $a 1 online resource (186 pages)
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500 $a Source: Dissertation Abstracts International, Volume: 79-01(E), Section: B.
500 $a Adviser: Chuan He.
502 $a Thesis (Ph.D.)--The University of Chicago, 2017.
504 $a Includes bibliographical references
520 $a Nucleic acids, one of the most essential biological macromolecules, store and transfer genetic information of all living organisms. They comprise of four canonical units: A, T, C, and G for DNA, and A, U, C, and G for RNA. Some of these units are chemically modified to record an extra dimension of information on top of the primary sequence. The existence of these modifications has been known for decades, yet the regulation and the functions of them remained largely elusive. My doctoral work is focused on the most prevalent chemical modification on human messenger RNA, N6-methyladenosine (m6A). Understanding the regulatory mechanism and cognate functions of m6A in various biological events is crucial for the clarification of how cells encode epigenetic information into chemical modifications for global gene regulation. The characterization of m6A metabolism may also provide valuable implications for the studies of complex biological processes and human diseases.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2018
538 $a Mode of access: World Wide Web
650 4 $a Biochemistry. $3 582831
650 4 $a Genetics. $3 578972
650 4 $a Molecular biology. $3 583443
655 7 $a Electronic books. $2 local $3 554714
690 $a 0487
690 $a 0369
690 $a 0307
710 2 $a ProQuest Information and Learning Co. $3 1178819
710 2 $a The University of Chicago. $b Chemistry. $3 1187113
773 0 $t Dissertation Abstracts International $g 79-01B(E).
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