國立虎尾科技大學 |

DNA Replication Control in Microbial Cell Factories

Record Type:	Language materials, printed : Monograph/item
Title/Author:	DNA Replication Control in Microbial Cell Factories/ by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn.
Author:	Glinkowska, Monika.
other author:	Boss, Lidia.
Description:	V, 50 p. 4 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Microbiology. -
Online resource:	https://doi.org/10.1007/978-3-319-10533-8
ISBN:	9783319105338

DNA Replication Control in Microbial Cell Factories
Glinkowska, Monika.

DNA Replication Control in Microbial Cell Factories[electronic resource] /by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn. - 1st ed. 2015. - V, 50 p. 4 illus. in color.online resource. - SpringerBriefs in Microbiology,2191-5385. - SpringerBriefs in Microbiology,.

Introduction.- Coordinating duplication of genetic material with cell growth – current views and old questions.- Structural organization of cellular processes and the regulation of cell cycle -- The link between metabolism and DNA replication -- Transcriptional activation – the unsolved problem -- Activity of DnaA is inhibited by components of translation machinery -- Nucleoid-associated proteins modulate activity of the DnaA initiator -- Interaction of DnaA with acidic components of fluid cellular membrane regulates its nucleotide-bound status and binding to oriC -- Influence of DNA replication on cell structure and function -- Conclusions.

This work describes the current knowledge of biochemical mechanisms regulating initiation of DNA replication in Escherichia coli, which focuses on the control of activity of the DnaA protein. Examples of direct linkages between DNA replication and other cellular processes are provided. In addition, similarities of the mechanisms of regulation of DNA replication operating in prokaryotic and eukaryotic cells are identified, and implications for understanding more complex processes, like carcinogenesis are suggested. Studies of recent years provided evidence that regulation of DNA replication in bacteria is more complex than previously anticipated. Multiple layers of control seem to ensure coordination of this process with the increase of cellular mass and the division cycle. Metabolic processes and membrane composition may serve as points where integration of genome replication with growth conditions occurs. It is also likely that coupling of DNA synthesis with cellular metabolism may involve interactions of replication proteins with other macromolecular complexes, responsible for various cellular processes. Thus, the exact set of factors participating in triggering the replication initiation may differ depending on growth conditions. Therefore, understanding the regulation of DNA duplication requires placing this process in the context of the current knowledge on bacterial metabolism, as well as cellular and chromosomal structure. Moreover, in both Escherichia coli and eukaryotic cells, replication initiator proteins were shown to play other roles in addition to driving the assembly of replication complexes, which constitutes another, yet not sufficiently understood, layer of coordinating DNA replication with the cell cycle.

ISBN: 9783319105338

Standard No.: 10.1007/978-3-319-10533-8doiSubjects--Topical Terms:

591510
Microbiology.

LC Class. No.: QR1-502

Dewey Class. No.: 579

DNA Replication Control in Microbial Cell Factories
LDR:03802nam a22003975i 4500 001 965964
003 DE-He213
005 20200630031213.0
007 cr nn 008mamaa
008 201211s2015 gw | s |||| 0|eng d
020 $a 9783319105338 $9 978-3-319-10533-8
024 7 $a 10.1007/978-3-319-10533-8 $2 doi
035 $a 978-3-319-10533-8
050 4 $a QR1-502
072 7 $a PSG $2 bicssc
072 7 $a SCI045000 $2 bisacsh
072 7 $a PSG $2 thema
082 0 4 $a 579 $2 23
100 1 $a Glinkowska, Monika. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1062603
245 1 0 $a DNA Replication Control in Microbial Cell Factories $h [electronic resource] / $c by Monika Glinkowska, Lidia Boss, Grzegorz Wegrzyn.
250 $a 1st ed. 2015.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2015.
300 $a V, 50 p. 4 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
490 1 $a SpringerBriefs in Microbiology, $x 2191-5385
505 0 $a Introduction.- Coordinating duplication of genetic material with cell growth – current views and old questions.- Structural organization of cellular processes and the regulation of cell cycle -- The link between metabolism and DNA replication -- Transcriptional activation – the unsolved problem -- Activity of DnaA is inhibited by components of translation machinery -- Nucleoid-associated proteins modulate activity of the DnaA initiator -- Interaction of DnaA with acidic components of fluid cellular membrane regulates its nucleotide-bound status and binding to oriC -- Influence of DNA replication on cell structure and function -- Conclusions.
520 $a This work describes the current knowledge of biochemical mechanisms regulating initiation of DNA replication in Escherichia coli, which focuses on the control of activity of the DnaA protein. Examples of direct linkages between DNA replication and other cellular processes are provided. In addition, similarities of the mechanisms of regulation of DNA replication operating in prokaryotic and eukaryotic cells are identified, and implications for understanding more complex processes, like carcinogenesis are suggested. Studies of recent years provided evidence that regulation of DNA replication in bacteria is more complex than previously anticipated. Multiple layers of control seem to ensure coordination of this process with the increase of cellular mass and the division cycle. Metabolic processes and membrane composition may serve as points where integration of genome replication with growth conditions occurs. It is also likely that coupling of DNA synthesis with cellular metabolism may involve interactions of replication proteins with other macromolecular complexes, responsible for various cellular processes. Thus, the exact set of factors participating in triggering the replication initiation may differ depending on growth conditions. Therefore, understanding the regulation of DNA duplication requires placing this process in the context of the current knowledge on bacterial metabolism, as well as cellular and chromosomal structure. Moreover, in both Escherichia coli and eukaryotic cells, replication initiator proteins were shown to play other roles in addition to driving the assembly of replication complexes, which constitutes another, yet not sufficiently understood, layer of coordinating DNA replication with the cell cycle.
650 0 $a Microbiology. $3 591510
650 0 $a Cell biology. $3 1253486
650 2 4 $a Applied Microbiology. $3 673403
650 2 4 $a Cell Biology. $3 593889
700 1 $a Boss, Lidia. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1062604
700 1 $a Wegrzyn, Grzegorz. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1062605
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783319105321
776 0 8 $i Printed edition: $z 9783319105345
830 0 $a SpringerBriefs in Microbiology, $x 2191-5385 $3 1255406
856 4 0 $u https://doi.org/10.1007/978-3-319-10533-8
912 $a ZDB-2-SBL
912 $a ZDB-2-SXB
950 $a Biomedical and Life Sciences (SpringerNature-11642)
950 $a Biomedical and Life Sciences (R0) (SpringerNature-43708)