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Adenoviral vectors for gene therapy

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Adenoviral vectors for gene therapy/ edited by David T. Curiel, Joanne T. Douglas.
其他作者:	Curiel, David.
出版者:	Amsterdam ;Academic Press, : c2002.,
面頁冊數:	1 online resource (xxviii, 677 p.) :ill. :
標題:	Gene therapy. -
電子資源:	http://www.sciencedirect.com/science/book/9780121995041
ISBN:	9780121995041

Adenoviral vectors for gene therapy
Adenoviral vectors for gene therapy[electronic resource] /edited by David T. Curiel, Joanne T. Douglas. - Amsterdam ;Academic Press,c2002. - 1 online resource (xxviii, 677 p.) :ill.

Includes bibliographical references.

Adenovirus Structure -- Biology of Adenovirus Cell Entry -- Adenovirus Replication -- Adenoviral Vector Construction I: Mammalian Systems -- Adenoviral Vector Construction II: Bacterial Systems -- Propagation of Adenoviral Vectors: Use of PER. C6 Cells -- Purification of Adenovirus -- Targeted Adenoviral Vectors I: Transductional Targeting -- Targeted Adenoviral Vectors II: Transcriptional Targeting -- Development of Attenuated Replication Competent Adenoviruses ARCAs) for the treatment of Prostate Cancer -- Replication-Selective Oncolytic Adenovirus EI-Region Mutants: Virotherapy for Cancer -- Innate Immune Responses to in Vivo Adenovirus Infection -- Humoral Immune Response -- Novel Methods to Eliminate the Immune Response to Adenovirus Gene Therapy -- High-Capacity "Gutless" Adenoviral Vectors: Technical Aspects and Applications -- Xenogenic Adenoviral Vectors -- Hybrid Adenoviral Vectors -- Utility of Adenoviral Vectors in Animal Models of Human Disease I: Cancer -- Utiltity of Adenoviral Vectors in Animal Models of Human Disease II: Genetic Disease -- Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases -- Testing of Adenoviral Vector Gene Transfer Products: FDA Expectations -- Imaging Adenovirus-Medicated Gene Transfer.

Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors. Key Features * Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors * Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement * Demonstrates noninvasive imaging of adenovirus-mediated gene transfer * Discusses utility of adenoviral vectors in animal disease models * Considers Federal Drug Administration regulations for human clinical trials.

ISBN: 9780121995041

Source: 89480:89480Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

582271
Gene therapy.
Index Terms--Genre/Form:

554714
Electronic books.

LC Class. No.: RB155.8 / .A34 2002eb

Dewey Class. No.: 616/.042

National Library of Medicine Call No.: 2002 H-966

Adenoviral vectors for gene therapy
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245 0 0 $a Adenoviral vectors for gene therapy $h [electronic resource] / $c edited by David T. Curiel, Joanne T. Douglas.
260 $a Amsterdam ; $a Boston : $b Academic Press, $c c2002.
300 $a 1 online resource (xxviii, 677 p.) : $b ill.
504 $a Includes bibliographical references.
505 0 $a Adenovirus Structure -- Biology of Adenovirus Cell Entry -- Adenovirus Replication -- Adenoviral Vector Construction I: Mammalian Systems -- Adenoviral Vector Construction II: Bacterial Systems -- Propagation of Adenoviral Vectors: Use of PER. C6 Cells -- Purification of Adenovirus -- Targeted Adenoviral Vectors I: Transductional Targeting -- Targeted Adenoviral Vectors II: Transcriptional Targeting -- Development of Attenuated Replication Competent Adenoviruses ARCAs) for the treatment of Prostate Cancer -- Replication-Selective Oncolytic Adenovirus EI-Region Mutants: Virotherapy for Cancer -- Innate Immune Responses to in Vivo Adenovirus Infection -- Humoral Immune Response -- Novel Methods to Eliminate the Immune Response to Adenovirus Gene Therapy -- High-Capacity "Gutless" Adenoviral Vectors: Technical Aspects and Applications -- Xenogenic Adenoviral Vectors -- Hybrid Adenoviral Vectors -- Utility of Adenoviral Vectors in Animal Models of Human Disease I: Cancer -- Utiltity of Adenoviral Vectors in Animal Models of Human Disease II: Genetic Disease -- Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases -- Testing of Adenoviral Vector Gene Transfer Products: FDA Expectations -- Imaging Adenovirus-Medicated Gene Transfer.
520 $a Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors. Key Features * Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors * Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement * Demonstrates noninvasive imaging of adenovirus-mediated gene transfer * Discusses utility of adenoviral vectors in animal disease models * Considers Federal Drug Administration regulations for human clinical trials.
588 $a Description based on print version record.
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650 0 $a Adenoviruses. $3 810748
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650 2 2 $a Adenoviridae. $3 810749
650 2 2 $a Genetic Vectors $x therapeutic use. $3 810750
650 6 $a Th�erapie g�enique. $3 810751
650 6 $a Ad�enovirus. $3 810752
650 7 $a HEALTH & FITNESS $x Diseases $x Genetic. $2 bisacsh $3 788733
650 7 $a MEDICAL $x Genetics. $2 bisacsh $3 788734
650 7 $a Adenov�irus. $2 larpcal $3 810753
650 7 $a Genes virais. $2 larpcal $3 810754
650 7 $a V�irus de dna. $2 larpcal $3 810755
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700 1 $a Curiel, David. $3 810747
700 1 $a Douglas, Joanne T. $3 676436
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