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Diffuse gastric cancer

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Diffuse gastric cancer/ edited by Tiago Biachi de Castria, Rodrigo Santa Cruz Guindalini.
other author:	Castria, Tiago Biachi de.
Published:	Cham :Springer International Publishing : : 2018.,
Description:	x, 81 p. :ill., digital ; : 24 cm.;
Contained By:	Springer eBooks
Subject:	Stomach - Cancer. -
Online resource:	http://dx.doi.org/10.1007/978-3-319-95234-5
ISBN:	9783319952345

Diffuse gastric cancer
Diffuse gastric cancer[electronic resource] /edited by Tiago Biachi de Castria, Rodrigo Santa Cruz Guindalini. - Cham :Springer International Publishing :2018. - x, 81 p. :ill., digital ;24 cm.

1. Introduction -- 2. Epidemiology -- 3. The Role of Endoscopy -- 4. Pathology and Molecular Biology -- 5. Genetic Predisposition and Hereditary Syndromes -- 6. The Role of Surgery -- 7. The Role of Radiotherapy -- 8. The Role of Chemotherapy.

We live in an era of personalized medicine and the knowledge about pathophysiology of diffuse gastric cancer has had many advances. Thus, the role of this work is to clarify what is new from diagnosis to treatment of this disease in order to treat patients in the most tailored manner as possible. Almost all phase III trials in gastric cancer have been performed without taking in consideration histologic subtypes, i.e. they have disregarded the differences between diffuse gastric cancer and general gastric cancer. However, the clinical practice reveals that diffuse gastric cancer is a completely distinct disease, with an aggressive course and generally worse prognosis. The loss of cohesion between tumor cells due to the loss of E-cadherin synthesis is the critical point on the oncogenesis of diffuse gastric cancer and is at the root of its marked heredity. This book intends to give special attention to Diffuse Gastric Cancer as a particular oncological entity, differentiating it from general gastric cancer, exploring and discussing all its peculiarities, and addressing the basic aspects (pathology and genetics) along with the most recent therapeutic alternatives for this condition.

ISBN: 9783319952345

Standard No.: 10.1007/978-3-319-95234-5doiSubjects--Topical Terms:

674283
Stomach
--Cancer.

LC Class. No.: RC280.S8 / D544 2018

Dewey Class. No.: 616.99433

Diffuse gastric cancer
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505 0 $a 1. Introduction -- 2. Epidemiology -- 3. The Role of Endoscopy -- 4. Pathology and Molecular Biology -- 5. Genetic Predisposition and Hereditary Syndromes -- 6. The Role of Surgery -- 7. The Role of Radiotherapy -- 8. The Role of Chemotherapy.
520 $a We live in an era of personalized medicine and the knowledge about pathophysiology of diffuse gastric cancer has had many advances. Thus, the role of this work is to clarify what is new from diagnosis to treatment of this disease in order to treat patients in the most tailored manner as possible. Almost all phase III trials in gastric cancer have been performed without taking in consideration histologic subtypes, i.e. they have disregarded the differences between diffuse gastric cancer and general gastric cancer. However, the clinical practice reveals that diffuse gastric cancer is a completely distinct disease, with an aggressive course and generally worse prognosis. The loss of cohesion between tumor cells due to the loss of E-cadherin synthesis is the critical point on the oncogenesis of diffuse gastric cancer and is at the root of its marked heredity. This book intends to give special attention to Diffuse Gastric Cancer as a particular oncological entity, differentiating it from general gastric cancer, exploring and discussing all its peculiarities, and addressing the basic aspects (pathology and genetics) along with the most recent therapeutic alternatives for this condition.
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650 2 4 $a Human Genetics. $3 593893
700 1 $a Castria, Tiago Biachi de. $3 1208852
700 1 $a Guindalini, Rodrigo Santa Cruz. $3 1208853
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