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Quantitative biology of endocytosis

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Quantitative biology of endocytosis/ Julien Berro, Michael M. Lacy.
作者:	Berro, Julien.
其他作者:	Lacy, Michael M.,
出版者:	San Rafael, California :Morgan & Claypool Life Sciences, : 2018.,
面頁冊數:	1 online resource (87 p.)
標題:	Endocytosis. -
電子資源:	click for full text
ISBN:	1615047840

Quantitative biology of endocytosis
Berro, Julien.

Quantitative biology of endocytosis[electronic resource] /Julien Berro, Michael M. Lacy. - San Rafael, California :Morgan & Claypool Life Sciences,2018. - 1 online resource (87 p.) - Colloquium Series on Quantitative Cell Biology.. - Colloquium Series on Quantitative Cell Biology..

Includes bibliographical references and index.

Quantitative biology of endocytosis -- Colloquium Digital Library of Life Sciences -- Colloquium Series on Quantitative Cell Biology -- Abstract -- Contents -- Frequently Used Abbreviations -- Chapter 1. Introduction to Clathrin-Mediated Endocytosis -- Chapter 2. Collecting Quantitative Data -- Chapter 3. From Raw Images to Quantitative Measurements: Extracting, Correcting, and Aligning the Fluorescen -- Chapter 4. Using Quantitative Microscopy Data to Infer the Molecular Mechanisms of Endocytosis -- Chapter 5. Perspectives and Future of Quantitative Biology of Endocytosis -- References -- Author Biographies.

Clathrin-mediated endocytosis (CME) is a ubiquitous internalization process in eukaryotic cells. It consists of the formation of an approximately 50-nm diameter vesicle out of a flat membrane. Genetics, biochemistry, and microscopy experiments performed in the last four decades have been instrumental to discover and characterize major endocytic proteins in yeast and mammals. However, due to the highly dynamic nature of the endocytic assembly and its small size, many questions remain unresolved: how are endocytic proteins organized spatially and dynamically? How are forces produced and how are their directions controlled? How do the biochemical activities of endocytic proteins and the membrane shape and mechanics regulate each other? These questions are virtually impossible to visualize or measure directly with conventional approaches but thanks to new quantitative biology methods, it is now possible to infer the mechanisms of endocytosis in exquisite detail. This book introduces quantitative microscopy and mathematical modeling approaches that have been used to count the copy number of endocytic proteins, infer their localization with nanometer precision, and infer molecular and physical mechanisms that are involved in the robust formation of endocytic vesicles.

ISBN: 1615047840Subjects--Topical Terms:

1075614
Endocytosis.

LC Class. No.: QH634

Dewey Class. No.: 571.655

Quantitative biology of endocytosis
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520 3 $a Clathrin-mediated endocytosis (CME) is a ubiquitous internalization process in eukaryotic cells. It consists of the formation of an approximately 50-nm diameter vesicle out of a flat membrane. Genetics, biochemistry, and microscopy experiments performed in the last four decades have been instrumental to discover and characterize major endocytic proteins in yeast and mammals. However, due to the highly dynamic nature of the endocytic assembly and its small size, many questions remain unresolved: how are endocytic proteins organized spatially and dynamically? How are forces produced and how are their directions controlled? How do the biochemical activities of endocytic proteins and the membrane shape and mechanics regulate each other? These questions are virtually impossible to visualize or measure directly with conventional approaches but thanks to new quantitative biology methods, it is now possible to infer the mechanisms of endocytosis in exquisite detail. This book introduces quantitative microscopy and mathematical modeling approaches that have been used to count the copy number of endocytic proteins, infer their localization with nanometer precision, and infer molecular and physical mechanisms that are involved in the robust formation of endocytic vesicles.
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