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Cancer Stem Cell Resistance to Targeted Therapy

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Cancer Stem Cell Resistance to Targeted Therapy/ edited by Cristina Maccalli, Matilde Todaro, Soldano Ferrone.
其他作者:	Maccalli, Cristina.
面頁冊數:	XIX, 256 p. 21 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Cancer research. -
電子資源:	https://doi.org/10.1007/978-3-030-16624-3
ISBN:	9783030166243

Cancer Stem Cell Resistance to Targeted Therapy
Cancer Stem Cell Resistance to Targeted Therapy[electronic resource] /edited by Cristina Maccalli, Matilde Todaro, Soldano Ferrone. - 1st ed. 2019. - XIX, 256 p. 21 illus. in color.online resource. - Resistance to Targeted Anti-Cancer Therapeutics,192196-5501 ;. - Resistance to Targeted Anti-Cancer Therapeutics,4.

Cancer Stem Cells: from birth to death -- A Cancer Stem Cell Perspective on Minimal Residual Disease in Solid Malignancies -- Cancer Stem Cells in Lung Cancer: Roots of Drug Resistance and Targets for Novel Therapeutic Strategies -- Overexpression of YY1 Regulates the Resistance of Cancer Stem Cells: Targeting YY1 -- Cancer Stem Cell Challenges in Melanoma Characterization and Treatment -- Harnessing the immune system to target cancer cells -- Targeting leukemia stem cells and the immunological bone marrow microenvironment -- Crosstalk Between Prostate Cancer Stem Cells and Immune Cells: Implications for Tumor Progression and Resistance to Immunotherapy -- Cancer stem cells: the players of immune evasion from immunotherapy -- Index.

This book represents an updated summary of the state of the art of the characterization of cancer stem cell/cancer initiating cell (CSC/CIC) properties. Experts provide an overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.

ISBN: 9783030166243

Standard No.: 10.1007/978-3-030-16624-3doiSubjects--Topical Terms:

1253664
Cancer research.

LC Class. No.: RC261-271

Dewey Class. No.: 614.5999

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