語系:
繁體中文
English
說明(常見問題)
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
HIV/AIDS: Immunochemistry, Reduction...
~
SpringerLink (Online service)
HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design = A Review of 20 Years of Research /
紀錄類型:
書目-語言資料,印刷品 : Monograph/item
正題名/作者:
HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design/ by Marc H V Van Regenmortel.
其他題名:
A Review of 20 Years of Research /
作者:
Van Regenmortel, Marc H V.
面頁冊數:
XXVII, 364 p. 20 illus., 12 illus. in color.online resource. :
Contained By:
Springer Nature eBook
標題:
Vaccines. -
電子資源:
https://doi.org/10.1007/978-3-030-32459-9
ISBN:
9783030324599
HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design = A Review of 20 Years of Research /
Van Regenmortel, Marc H V.
HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design
A Review of 20 Years of Research /[electronic resource] :by Marc H V Van Regenmortel. - 1st ed. 2019. - XXVII, 364 p. 20 illus., 12 illus. in color.online resource.
Part I.Immunochemistry -- 1 What is a B cell epitope -- 2 Molecular design versus empirical discovery in peptide-based vaccines. Coming to terms with fuzzy recognition sites and ill-defined structure–function relationships in immunology -- 3 Synthetic Peptide Vaccines and the Search for Neutralization B Cell Epitopes -- 4 Specificity, polyspecificity, and heterospecificity of antibody‐antigen recognition -- Part II. Reductionism -- 5 Reductionism and the search for structure–function relationships in antibody molecules -- 6 Reductionism and complexity in molecular biology -- 7 Editorial: Biological complexity emerges from the ashes of genetic reductionism -- 8 The rational design of biological complexity: A deceptive metaphor., 9 Basic research in HIV vaccinology is hampered by reductionist thinking -- 10 Commentary: Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking -- 11 Nature and Consequences of Biological Reductionism for the Immunological Study of Infectious Diseases., Part III. Vaccinology -- 12 Limitations to the structure‐based design of HIV‐1 vaccine immunogens -- 13 Two meanings of reverse vaccinology and the empirical nature of vaccine science -- 14 Requirements for empirical immunogenicity trials, rather than structure-based design, for developing an effective HIV vaccine -- 15 Paradigm Changes and the Future of HIV Vaccine Research: A Summary of a Workshop Held in Baltimore on 20 November 2013 -- 16 Editorial: Paradigm changes are required in HIV vaccine research -- 17 An outdated notion of antibody specificity is one of the major detrimental assumptions of the structure-based reverse vaccinology paradigm, which prevented it from helping to develop an effective HIV-1 vaccine -- 18 More surprises in the development of an HIV vaccine -- 19 Why Does the Molecular Structure of Broadly Neutralizing Monoclonal Antibodies Isolated from Individuals Infected with HIV-1 not Inform the Rational Design of an HIV-1 Vaccine? -- 20 Old and New Concepts and Strategies in HIV Vaccinology: A Report from a Workshop held in Rome on 17 June 2016 -- 21 Structure-Based Reverse Vaccinology Failed in the Case of HIV Because it Disregarded Accepted Immunological Theory -- 22 Immune systems rather than antigenic epitopes elicit and produce protective antibodies against HIV -- 23 Development of a Preventive HIV Vaccine Requires Solving Inverse Problems Which Is Unattainable by Rational Vaccine Design -- 24 Viral species, viral genomes and HIV vaccine design: is the rational design of biological complexity a utopia?
This book gathers a series of pivotal papers on the development of an HIV/AIDS vaccine published in the last two decades. Accompanied by extensive comments putting the material into an up-to-date context, all three parts of the book offer a broad overview of the numerous unsuccessful attempts made in recent years to develop a preventive HIV vaccine. Providing a detailed review and analysis of studies published from 1998 to the present day, it examines the likely reasons for the failure to develop an HIV vaccine despite multi-million dollar investments.
ISBN: 9783030324599
Standard No.: 10.1007/978-3-030-32459-9doiSubjects--Topical Terms:
582184
Vaccines.
LC Class. No.: RM281
Dewey Class. No.: 615.372
HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design = A Review of 20 Years of Research /
LDR
:04579nam a22004095i 4500
001
1005065
003
DE-He213
005
20200702033046.0
007
cr nn 008mamaa
008
210106s2019 gw | s |||| 0|eng d
020
$a
9783030324599
$9
978-3-030-32459-9
024
7
$a
10.1007/978-3-030-32459-9
$2
doi
035
$a
978-3-030-32459-9
050
4
$a
RM281
050
4
$a
QR189-189.5
072
7
$a
MJCM
$2
bicssc
072
7
$a
MED044000
$2
bisacsh
072
7
$a
MJCM
$2
thema
082
0 4
$a
615.372
$2
23
100
1
$a
Van Regenmortel, Marc H V.
$e
author.
$4
aut
$4
http://id.loc.gov/vocabulary/relators/aut
$3
1298565
245
1 0
$a
HIV/AIDS: Immunochemistry, Reductionism and Vaccine Design
$h
[electronic resource] :
$b
A Review of 20 Years of Research /
$c
by Marc H V Van Regenmortel.
250
$a
1st ed. 2019.
264
1
$a
Cham :
$b
Springer International Publishing :
$b
Imprint: Springer,
$c
2019.
300
$a
XXVII, 364 p. 20 illus., 12 illus. in color.
$b
online resource.
336
$a
text
$b
txt
$2
rdacontent
337
$a
computer
$b
c
$2
rdamedia
338
$a
online resource
$b
cr
$2
rdacarrier
347
$a
text file
$b
PDF
$2
rda
505
0
$a
Part I.Immunochemistry -- 1 What is a B cell epitope -- 2 Molecular design versus empirical discovery in peptide-based vaccines. Coming to terms with fuzzy recognition sites and ill-defined structure–function relationships in immunology -- 3 Synthetic Peptide Vaccines and the Search for Neutralization B Cell Epitopes -- 4 Specificity, polyspecificity, and heterospecificity of antibody‐antigen recognition -- Part II. Reductionism -- 5 Reductionism and the search for structure–function relationships in antibody molecules -- 6 Reductionism and complexity in molecular biology -- 7 Editorial: Biological complexity emerges from the ashes of genetic reductionism -- 8 The rational design of biological complexity: A deceptive metaphor., 9 Basic research in HIV vaccinology is hampered by reductionist thinking -- 10 Commentary: Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking -- 11 Nature and Consequences of Biological Reductionism for the Immunological Study of Infectious Diseases., Part III. Vaccinology -- 12 Limitations to the structure‐based design of HIV‐1 vaccine immunogens -- 13 Two meanings of reverse vaccinology and the empirical nature of vaccine science -- 14 Requirements for empirical immunogenicity trials, rather than structure-based design, for developing an effective HIV vaccine -- 15 Paradigm Changes and the Future of HIV Vaccine Research: A Summary of a Workshop Held in Baltimore on 20 November 2013 -- 16 Editorial: Paradigm changes are required in HIV vaccine research -- 17 An outdated notion of antibody specificity is one of the major detrimental assumptions of the structure-based reverse vaccinology paradigm, which prevented it from helping to develop an effective HIV-1 vaccine -- 18 More surprises in the development of an HIV vaccine -- 19 Why Does the Molecular Structure of Broadly Neutralizing Monoclonal Antibodies Isolated from Individuals Infected with HIV-1 not Inform the Rational Design of an HIV-1 Vaccine? -- 20 Old and New Concepts and Strategies in HIV Vaccinology: A Report from a Workshop held in Rome on 17 June 2016 -- 21 Structure-Based Reverse Vaccinology Failed in the Case of HIV Because it Disregarded Accepted Immunological Theory -- 22 Immune systems rather than antigenic epitopes elicit and produce protective antibodies against HIV -- 23 Development of a Preventive HIV Vaccine Requires Solving Inverse Problems Which Is Unattainable by Rational Vaccine Design -- 24 Viral species, viral genomes and HIV vaccine design: is the rational design of biological complexity a utopia?
520
$a
This book gathers a series of pivotal papers on the development of an HIV/AIDS vaccine published in the last two decades. Accompanied by extensive comments putting the material into an up-to-date context, all three parts of the book offer a broad overview of the numerous unsuccessful attempts made in recent years to develop a preventive HIV vaccine. Providing a detailed review and analysis of studies published from 1998 to the present day, it examines the likely reasons for the failure to develop an HIV vaccine despite multi-million dollar investments.
650
0
$a
Vaccines.
$3
582184
650
0
$a
Virology.
$3
644995
650
1 4
$a
Vaccine.
$3
782685
710
2
$a
SpringerLink (Online service)
$3
593884
773
0
$t
Springer Nature eBook
776
0 8
$i
Printed edition:
$z
9783030324582
776
0 8
$i
Printed edition:
$z
9783030324605
776
0 8
$i
Printed edition:
$z
9783030324612
856
4 0
$u
https://doi.org/10.1007/978-3-030-32459-9
912
$a
ZDB-2-SBL
912
$a
ZDB-2-SXB
950
$a
Biomedical and Life Sciences (SpringerNature-11642)
950
$a
Biomedical and Life Sciences (R0) (SpringerNature-43708)
筆 0 讀者評論
多媒體
評論
新增評論
分享你的心得
Export
取書館別
處理中
...
變更密碼[密碼必須為2種組合(英文和數字)及長度為10碼以上]
登入