國立虎尾科技大學 |

Insights into Human Neurodegeneration: Lessons Learnt from Drosophila

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Insights into Human Neurodegeneration: Lessons Learnt from Drosophila/ edited by Mousumi Mutsuddi, Ashim Mukherjee.
其他作者:	Mutsuddi, Mousumi.
面頁冊數:	X, 467 p. 48 illus., 43 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Neurosciences. -
電子資源:	https://doi.org/10.1007/978-981-13-2218-1
ISBN:	9789811322181

Insights into Human Neurodegeneration: Lessons Learnt from Drosophila
Insights into Human Neurodegeneration: Lessons Learnt from Drosophila[electronic resource] /edited by Mousumi Mutsuddi, Ashim Mukherjee. - 1st ed. 2019. - X, 467 p. 48 illus., 43 illus. in color.online resource.

Chapter 1. Introduction to Drosophila as a model organism -- Chapter 2. Methods for creating fly models in order to understand molecular mechanism of neurological diseases -- Chapter 3. Neurodegeneration: Lessons learnt from forward genetic screens in Drosophila -- Chapter 4. Drosophila neural stem cells, a primer for understanding mammalian neurobiology -- Chapter 5. Understanding motor disorders using flies -- Chapter 6. Metabolic alterations amalgamated with neurodegenerative diseases -- Chapter 7. Notch signalling in neurodegenerative disease -- Chapter 8. Drosophila model of neurofibrillar tangles -- Chapter 9. Unraveling Alzheimer's disease using Drosophila -- Chapter 10. Modelling Human Parkinson's disease in fly -- Chapter 11. Post-translational modifications: A mystery to unravel Huntington’s disease -- Chapter 12. Understanding the pathogenicity of non-coding RNA expansion associated neurodegenerative disorders -- Chapter 13. Expanding roles of RNA binding proteins in neurodegeneration -- Chapter 14. Hereditary Spastic Paraplegia Disease in Drosophila -- Chapter 15. Drosophila as a model system for the identification of pharmacological therapies in neurodegenerative diseases.

This book is aimed at generating an updated reservoir of scientific endeavors undertaken to unravel the complicated yet intriguing topic of neurodegeneration. Scientists from Europe, USA and India who are experts in the field of neurodegenerative diseases have contributed to this book. This book will help readers gain insight into the recent knowledge obtained from Drosophila model, in understanding the molecular mechanisms underlying neurodegenerative disorders and also unravel novel scopes for therapeutic interventions. Different methodologies available to create humanized fly models that faithfully reflects the pathogenicities associated with particular disorders have been described here. It also includes information on the exciting area of neural stem cells. A brief discussion on neurofibrillary tangles, precedes the elaborate description of lessons learnt from Drosophila about Alzheimer's, Parkinson’s, Spinomuscular Atrophy, Huntington’s diseases, RNA expansion disorders and Hereditary Spastic Paraplegia. We have concluded the book with the use of Drosophila for identifying pharmacological therapies for neurodegenerative disorders. The wide range of topics covered here will not only be relevant for beginners who are new to the concept of the extensive utility of Drosophila as a model to study human disorders; but will also be an important contribution to the scientific community, with an insight into the paradigm shift in our understanding of neurodegenerative disorders. Completed with informative tables and communicative illustrations this book will keep the readers glued and intrigued. We have comprehensively anthologized the lessons learnt on neurodegeneration from Drosophila and have thus provided an insight into the multidimensional aspects of pathogenicities of majority of the neurodegenerative disorders.

ISBN: 9789811322181

Standard No.: 10.1007/978-981-13-2218-1doiSubjects--Topical Terms:

593561
Neurosciences.

LC Class. No.: RC321-580

Dewey Class. No.: 612.8

Insights into Human Neurodegeneration: Lessons Learnt from Drosophila
LDR:04453nam a22003975i 4500 001 1005416
003 DE-He213
005 20200702014004.0
007 cr nn 008mamaa
008 210106s2019 si | s |||| 0|eng d
020 $a 9789811322181 $9 978-981-13-2218-1
024 7 $a 10.1007/978-981-13-2218-1 $2 doi
035 $a 978-981-13-2218-1
050 4 $a RC321-580
072 7 $a PSAN $2 bicssc
072 7 $a MED057000 $2 bisacsh
072 7 $a PSAN $2 thema
082 0 4 $a 612.8 $2 23
245 1 0 $a Insights into Human Neurodegeneration: Lessons Learnt from Drosophila $h [electronic resource] / $c edited by Mousumi Mutsuddi, Ashim Mukherjee.
250 $a 1st ed. 2019.
264 1 $a Singapore : $b Springer Singapore : $b Imprint: Springer, $c 2019.
300 $a X, 467 p. 48 illus., 43 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
505 0 $a Chapter 1. Introduction to Drosophila as a model organism -- Chapter 2. Methods for creating fly models in order to understand molecular mechanism of neurological diseases -- Chapter 3. Neurodegeneration: Lessons learnt from forward genetic screens in Drosophila -- Chapter 4. Drosophila neural stem cells, a primer for understanding mammalian neurobiology -- Chapter 5. Understanding motor disorders using flies -- Chapter 6. Metabolic alterations amalgamated with neurodegenerative diseases -- Chapter 7. Notch signalling in neurodegenerative disease -- Chapter 8. Drosophila model of neurofibrillar tangles -- Chapter 9. Unraveling Alzheimer's disease using Drosophila -- Chapter 10. Modelling Human Parkinson's disease in fly -- Chapter 11. Post-translational modifications: A mystery to unravel Huntington’s disease -- Chapter 12. Understanding the pathogenicity of non-coding RNA expansion associated neurodegenerative disorders -- Chapter 13. Expanding roles of RNA binding proteins in neurodegeneration -- Chapter 14. Hereditary Spastic Paraplegia Disease in Drosophila -- Chapter 15. Drosophila as a model system for the identification of pharmacological therapies in neurodegenerative diseases.
520 $a This book is aimed at generating an updated reservoir of scientific endeavors undertaken to unravel the complicated yet intriguing topic of neurodegeneration. Scientists from Europe, USA and India who are experts in the field of neurodegenerative diseases have contributed to this book. This book will help readers gain insight into the recent knowledge obtained from Drosophila model, in understanding the molecular mechanisms underlying neurodegenerative disorders and also unravel novel scopes for therapeutic interventions. Different methodologies available to create humanized fly models that faithfully reflects the pathogenicities associated with particular disorders have been described here. It also includes information on the exciting area of neural stem cells. A brief discussion on neurofibrillary tangles, precedes the elaborate description of lessons learnt from Drosophila about Alzheimer's, Parkinson’s, Spinomuscular Atrophy, Huntington’s diseases, RNA expansion disorders and Hereditary Spastic Paraplegia. We have concluded the book with the use of Drosophila for identifying pharmacological therapies for neurodegenerative disorders. The wide range of topics covered here will not only be relevant for beginners who are new to the concept of the extensive utility of Drosophila as a model to study human disorders; but will also be an important contribution to the scientific community, with an insight into the paradigm shift in our understanding of neurodegenerative disorders. Completed with informative tables and communicative illustrations this book will keep the readers glued and intrigued. We have comprehensively anthologized the lessons learnt on neurodegeneration from Drosophila and have thus provided an insight into the multidimensional aspects of pathogenicities of majority of the neurodegenerative disorders.
650 0 $a Neurosciences. $3 593561
650 0 $a Developmental biology. $3 669036
650 0 $a Animal models in research. $3 581737
650 0 $a Stem cells. $3 679759
650 0 $a Posttranslational modification. $3 1253492
650 2 4 $a Developmental Biology. $3 668567
650 2 4 $a Animal Models. $3 784995
650 2 4 $a Stem Cells. $3 782732
650 2 4 $a Posttranslational Modification. $3 786934
700 1 $a Mutsuddi, Mousumi. $e editor. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1298868
700 1 $a Mukherjee, Ashim. $e editor. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1298869
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9789811322174
776 0 8 $i Printed edition: $z 9789811322198
776 0 8 $i Printed edition: $z 9789813299139
856 4 0 $u https://doi.org/10.1007/978-981-13-2218-1
912 $a ZDB-2-SBL
912 $a ZDB-2-SXB
950 $a Biomedical and Life Sciences (SpringerNature-11642)
950 $a Biomedical and Life Sciences (R0) (SpringerNature-43708)