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The Nociceptin/Orphanin FQ Peptide Receptor

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The Nociceptin/Orphanin FQ Peptide Receptor/ edited by Mei-Chuan Ko, Girolamo Caló.
other author:	Ko, Mei-Chuan.
Description:	X, 417 p. 78 illus., 21 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Pharmacology. -
Online resource:	https://doi.org/10.1007/978-3-030-20186-9
ISBN:	9783030201869

The Nociceptin/Orphanin FQ Peptide Receptor
The Nociceptin/Orphanin FQ Peptide Receptor[electronic resource] /edited by Mei-Chuan Ko, Girolamo Caló. - 1st ed. 2019. - X, 417 p. 78 illus., 21 illus. in color.online resource. - Handbook of Experimental Pharmacology,2540171-2004 ;. - Handbook of Experimental Pharmacology,224.

PART I. The N/OFQ-NOP Receptor System -- 1. The History of N/OFQ and the NOP Receptor -- 2. NOP-Targeted Peptide Ligands -- 3. NOP-Targeted Nonpeptide Ligands -- 4. Pharmacological Assays for Investigating the NOP Receptor -- 5. Electrophysiological Actions of N/OFQ -- 6. NOP Receptor Signaling Cascades -- 7.Regulation of the Genes Encoding the ppN/OFQ and NOP Receptor -- PART II. Biological Actions of NOP Ligands -- 8.NOP-Related Mechanisms in Pain and Analgesia -- 9. NOP-Related Mechanisms in Substance Use Disorders -- 10. NOP Receptor Ligands and Parkinson’s Disease -- 11. NOP Ligands for the Treatment of Anxiety and Mood Disorders -- 12. The Nociceptin/Orphanin FQ System and the Regulation of Memory -- 13. N/OFQ-NOP System in Food Intake -- 14. N/OFQ-NOP System in Peripheral and Central Immunomodulation -- 15. N/OFQ-NOP System and Airways -- 16. Effects of NOP-Related Ligands in Nonhuman Primates -- PART III. First Clinical Studies with NOP Ligands -- 17. Nociceptin/Orphanin FQ and Urinary Bladder -- 18. Cebranopadol: A Novel First-in-Class Potent Analgesic Acting via NOP and Opioid Receptors -- 19. Therapeutic Approaches for NOP Receptor Antagonists in Neurobehavioral Disorders: Clinical Studies in Major Depressive Disorder and Alcohol Use Disorder with BTRX-246040 (LY2940094) -- 20. Correction to: Electrophysiological Actions of N/OFQ.

The aim of this book is not only to introduce readers with a broad spectrum of biological actions of the NOP receptor, but also to feature a detailed look at the N/OFQ-NOP receptor system, medicinal chemistry, pharmacology, and clinical data of NOP-targeted ligands. This special volume book - for the first time focusing on the NOP receptor - is designed to serve as a useful reference, stimulate more research on the N/OFQ-NOP receptor system, and lead to more development of NOP-related ligands for several therapeutic applications.

ISBN: 9783030201869

Standard No.: 10.1007/978-3-030-20186-9doiSubjects--Topical Terms:

583819
Pharmacology.

LC Class. No.: RM1-950

Dewey Class. No.: 615

The Nociceptin/Orphanin FQ Peptide Receptor
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