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Spherical Crystallization as a New Platform for Particle Design Engineering

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Spherical Crystallization as a New Platform for Particle Design Engineering/ by Yoshiaki Kawashima.
Author:	Kawashima, Yoshiaki.
Description:	XVII, 118 p. 110 illus., 32 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Pharmaceutical technology. -
Online resource:	https://doi.org/10.1007/978-981-13-6786-1
ISBN:	9789811367861

Spherical Crystallization as a New Platform for Particle Design Engineering
Kawashima, Yoshiaki.

Spherical Crystallization as a New Platform for Particle Design Engineering[electronic resource] /by Yoshiaki Kawashima. - 1st ed. 2019. - XVII, 118 p. 110 illus., 32 illus. in color.online resource.

Introduction -- Concept of spherical crystallization -- Paradigm shifted pharmaceutical process introduced by spherical crystallization -- Particulate-design platform developed by the Advanced Spherical Crystallization System -- Development of Novel Microsphere and Microballoon DDS by Polymeric Spherical Crystallization -- Development of PLGA Nanopsphere for Drug Delivery System (DDS) Prepared by Polymeric Spherical Crystallization -- Application of PLGA NSs to cosmetics -- Future perspectives of PLGA nanospheres for advanced DDSs and continuous preparation systems for spherical crystallizers.

This book describes the principles and applications of the spherical crystallization technique, from the standpoint of its inventor. After an introduction on the history of particle design engineering and nanotechnology, the concept of spherical crystallization itself is clearly explained. Attention then turns to the application of spherical crystallization in pharmaceutical processes. It is explained how the technique can provide physicochemical properties suitable for direct tableting of active pharmaceutical ingredients and how it has enabled the development of a novel particulate design platform from single to complex system. Subsequent chapters describe the roles of polymeric spherical crystallization in the preparation of novel microspheres, microballoons for drug delivery systems (DDS) and the development of biocompatible and biodegradable poly(D,L-lactide-co-glycolide) (PLGA) nanospheres. The various applications of PLGA nanospheres composite within oral-, pulmonary-, transdermal DDS and cosmetics are fully discussed. Finally, future perspectives are presented on use of the technology in the design and industrial-scale manufacture of new drug delivery systems, highlighting how a continuous pharmaceutical process that meets US Food and Drug Administration quality requirements should soon be introduced.

ISBN: 9789811367861

Standard No.: 10.1007/978-981-13-6786-1doiSubjects--Topical Terms:

557391
Pharmaceutical technology.

LC Class. No.: RS380

Dewey Class. No.: 615.19

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505 0 $a Introduction -- Concept of spherical crystallization -- Paradigm shifted pharmaceutical process introduced by spherical crystallization -- Particulate-design platform developed by the Advanced Spherical Crystallization System -- Development of Novel Microsphere and Microballoon DDS by Polymeric Spherical Crystallization -- Development of PLGA Nanopsphere for Drug Delivery System (DDS) Prepared by Polymeric Spherical Crystallization -- Application of PLGA NSs to cosmetics -- Future perspectives of PLGA nanospheres for advanced DDSs and continuous preparation systems for spherical crystallizers.
520 $a This book describes the principles and applications of the spherical crystallization technique, from the standpoint of its inventor. After an introduction on the history of particle design engineering and nanotechnology, the concept of spherical crystallization itself is clearly explained. Attention then turns to the application of spherical crystallization in pharmaceutical processes. It is explained how the technique can provide physicochemical properties suitable for direct tableting of active pharmaceutical ingredients and how it has enabled the development of a novel particulate design platform from single to complex system. Subsequent chapters describe the roles of polymeric spherical crystallization in the preparation of novel microspheres, microballoons for drug delivery systems (DDS) and the development of biocompatible and biodegradable poly(D,L-lactide-co-glycolide) (PLGA) nanospheres. The various applications of PLGA nanospheres composite within oral-, pulmonary-, transdermal DDS and cosmetics are fully discussed. Finally, future perspectives are presented on use of the technology in the design and industrial-scale manufacture of new drug delivery systems, highlighting how a continuous pharmaceutical process that meets US Food and Drug Administration quality requirements should soon be introduced.
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