國立虎尾科技大學 |

Antimicrobial Peptides = Basics for Clinical Application /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Antimicrobial Peptides/ edited by Katsumi Matsuzaki.
Reminder of title:	Basics for Clinical Application /
other author:	Matsuzaki, Katsumi.
Description:	VIII, 304 p. 73 illus., 55 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Pharmacology. -
Online resource:	https://doi.org/10.1007/978-981-13-3588-4
ISBN:	9789811335884

Antimicrobial Peptides = Basics for Clinical Application /
Antimicrobial PeptidesBasics for Clinical Application /[electronic resource] :edited by Katsumi Matsuzaki. - 1st ed. 2019. - VIII, 304 p. 73 illus., 55 illus. in color.online resource. - Advances in Experimental Medicine and Biology,11170065-2598 ;. - Advances in Experimental Medicine and Biology,889.

Part 1. Introduction -- Chapter 1. Antimicrobial peptides of multicellular organisms: My perspective -- Part 2. Mechanisms of Antimicrobial Action -- Chapter 2. Membrane permeabilization mechanisms -- Chapter 3. Elementary processes and mechanisms of interactions of antimicrobial peptides with membranes --- single GUV studies ---- -- Chapter 4. The mechanisms of action of cationic antimicrobial peptides refined by novel concepts from biophysical investigations -- Chapter 5. Anionic lipid clustering model -- Chapter 6. Intracellular antimicrobial peptides targeting the protein synthesis machinery -- Part 3. Other activities of AMPs -- Chapter 7. Antimicrobial and cell-penetrating peptides: How to understand two distinct functions despite similar physicochemical properties -- Chapter 8. Synthetic anti-lipopolysaccharide peptides (SALP) as effective inhibitors of pathogen-associated molecular patterns (PAMPs) -- Chapter 9. Anti-cancer activities of natural and synthetic peptides -- Chapter 10. Antimicrobial host defence peptides: Immunomodulatory functions and translational prospects -- Part 4. Towards Clinical Applications -- Chapter 11. Activity and selectivity of antimicrobial peptides: A complex interplay of multiple equilibria -- Chapter 12. Design of antimicrobial peptides: Progress made with human cathelicidin LL-37 -- Chapter 13. Application of synthetic molecular evolution to the discovery of antimicrobial peptides -- Chapter 14. AMPs as anti-biofilm agents for human therapy and prophylaxis -- Chapter 15. Clinical application of AMPs. .

This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.

ISBN: 9789811335884

Standard No.: 10.1007/978-981-13-3588-4doiSubjects--Topical Terms:

583819
Pharmacology.

LC Class. No.: RM1-950

Dewey Class. No.: 615

Antimicrobial Peptides = Basics for Clinical Application /
LDR:04242nam a22003975i 4500 001 1008330
003 DE-He213
005 20200704060834.0
007 cr nn 008mamaa
008 210106s2019 si | s |||| 0|eng d
020 $a 9789811335884 $9 978-981-13-3588-4
024 7 $a 10.1007/978-981-13-3588-4 $2 doi
035 $a 978-981-13-3588-4
050 4 $a RM1-950
072 7 $a MMG $2 bicssc
072 7 $a MED071000 $2 bisacsh
072 7 $a MKG $2 thema
082 0 4 $a 615 $2 23
245 1 0 $a Antimicrobial Peptides $h [electronic resource] : $b Basics for Clinical Application / $c edited by Katsumi Matsuzaki.
250 $a 1st ed. 2019.
264 1 $a Singapore : $b Springer Singapore : $b Imprint: Springer, $c 2019.
300 $a VIII, 304 p. 73 illus., 55 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
490 1 $a Advances in Experimental Medicine and Biology, $x 0065-2598 ; $v 1117
505 0 $a Part 1. Introduction -- Chapter 1. Antimicrobial peptides of multicellular organisms: My perspective -- Part 2. Mechanisms of Antimicrobial Action -- Chapter 2. Membrane permeabilization mechanisms -- Chapter 3. Elementary processes and mechanisms of interactions of antimicrobial peptides with membranes --- single GUV studies ---- -- Chapter 4. The mechanisms of action of cationic antimicrobial peptides refined by novel concepts from biophysical investigations -- Chapter 5. Anionic lipid clustering model -- Chapter 6. Intracellular antimicrobial peptides targeting the protein synthesis machinery -- Part 3. Other activities of AMPs -- Chapter 7. Antimicrobial and cell-penetrating peptides: How to understand two distinct functions despite similar physicochemical properties -- Chapter 8. Synthetic anti-lipopolysaccharide peptides (SALP) as effective inhibitors of pathogen-associated molecular patterns (PAMPs) -- Chapter 9. Anti-cancer activities of natural and synthetic peptides -- Chapter 10. Antimicrobial host defence peptides: Immunomodulatory functions and translational prospects -- Part 4. Towards Clinical Applications -- Chapter 11. Activity and selectivity of antimicrobial peptides: A complex interplay of multiple equilibria -- Chapter 12. Design of antimicrobial peptides: Progress made with human cathelicidin LL-37 -- Chapter 13. Application of synthetic molecular evolution to the discovery of antimicrobial peptides -- Chapter 14. AMPs as anti-biofilm agents for human therapy and prophylaxis -- Chapter 15. Clinical application of AMPs. .
520 $a This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.
650 0 $a Pharmacology. $3 583819
650 0 $a Biophysics. $3 581576
650 0 $a Biological physics. $3 1253579
650 0 $a Biochemistry. $3 582831
650 0 $a Cancer research. $3 1253664
650 1 4 $a Pharmacology/Toxicology. $3 593882
650 2 4 $a Biological and Medical Physics, Biophysics. $3 1113305
650 2 4 $a Biochemistry, general. $3 593881
650 2 4 $a Cancer Research. $3 668358
700 1 $a Matsuzaki, Katsumi. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1225749
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9789811335877
776 0 8 $i Printed edition: $z 9789811335891
830 0 $a Advances in Experimental Medicine and Biology, $x 0065-2598 ; $v 889 $3 1253792
856 4 0 $u https://doi.org/10.1007/978-981-13-3588-4
912 $a ZDB-2-SBL
912 $a ZDB-2-SXB
950 $a Biomedical and Life Sciences (SpringerNature-11642)
950 $a Biomedical and Life Sciences (R0) (SpringerNature-43708)