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The Unfolded Protein Response in Cancer

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The Unfolded Protein Response in Cancer/ edited by Robert Clarke.
other author:	Clarke, Robert.
Description:	XI, 220 p. 15 illus., 14 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Cancer research. -
Online resource:	https://doi.org/10.1007/978-3-030-05067-2
ISBN:	9783030050672

The Unfolded Protein Response in Cancer
The Unfolded Protein Response in Cancer[electronic resource] /edited by Robert Clarke. - 1st ed. 2019. - XI, 220 p. 15 illus., 14 illus. in color.online resource. - Cancer Drug Discovery and Development,2196-9906. - Cancer Drug Discovery and Development,.

Introduction: The Unfolded Protein Response -- Endoplasmic Reticulum Stress Signaling During Development -- Regulation of the Unfolded Protein Response and its Roles in Tumorigenesis and Cancer Therapy -- ATF4, Hypoxia and Treatment Resistance in Cancer -- Role of Protein Translation in the Unfolded Protein Response -- Roles of Spliced and Unspliced XBP1 in Breast Cancer -- The Unfolded Protein Response in Triple-Negative Breast Cancer -- The Unfolded Protein Response as an Integrator of Response to Endocrine Therapy in Estrogen Receptor Positive Breast Cancer -- Outside the Endoplasmic Reticulum: Non-Canonical GRP78 Signaling -- Autophagy and the Unfolded Protein Response in Neurodegenerative Diseases -- Index.

This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.

ISBN: 9783030050672

Standard No.: 10.1007/978-3-030-05067-2doiSubjects--Topical Terms:

1253664
Cancer research.

LC Class. No.: RC261-271

Dewey Class. No.: 614.5999

The Unfolded Protein Response in Cancer
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