國立虎尾科技大學 |

A Phenomenological Mathematical Modelling Framework for the Degradation of Bioresorbable Composites

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	A Phenomenological Mathematical Modelling Framework for the Degradation of Bioresorbable Composites/ by Ismael Moreno-Gomez.
作者:	Moreno-Gomez, Ismael.
面頁冊數:	XLIII, 325 p. 383 illus., 262 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Biomaterials. -
電子資源:	https://doi.org/10.1007/978-3-030-04990-4
ISBN:	9783030049904

A Phenomenological Mathematical Modelling Framework for the Degradation of Bioresorbable Composites
Moreno-Gomez, Ismael.

A Phenomenological Mathematical Modelling Framework for the Degradation of Bioresorbable Composites[electronic resource] /by Ismael Moreno-Gomez. - 1st ed. 2019. - XLIII, 325 p. 383 illus., 262 illus. in color.online resource. - Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053. - Springer Theses, Recognizing Outstanding Ph.D. Research,.

Introduction -- Literature review -- Degradation of bioresorbable composites: the models -- Degradation of bioresorbable composites: tricalcium phosphate case studies -- Degradation of bioresorbable composites: hydroxyapatite case studies -- Experimental degradation study of PLGA–CaCO3 nanocomposites -- Degradation of bioresorbable composites: calcium carbonate case studies -- Conclusions and future work -- Appendix.

This book presents a generalised computational model for the degradation of resorbable composites, using analytic expressions to represent the interwoven phenomena present during degradation. It then combines this modelling framework with a comprehensive database of quantitative degradation data mined from existing literature and from novel experiments, to provide new insights into the interrelated factors controlling degradation. Resorbable composites made of biodegradable polyesters and calcium-based ceramics have significant therapeutic potential as tissue engineering scaffolds, as temporary implants and as drug-loaded matrices for controlled release. However, their degradation is complex and the rate of resorption depends on multiple connected factors such as the shape and size of the device, polymer chemistry and molecular weight, particle phase, size, volume fraction, distribution and pH-dependent dissolution properties. Understanding and ultimately predicting the degradation of resorbable composites is of central importance if we are to fully unlock the promise of these materials.

ISBN: 9783030049904

Standard No.: 10.1007/978-3-030-04990-4doiSubjects--Topical Terms:

677000
Biomaterials.

LC Class. No.: R857.M3

Dewey Class. No.: 620.11

A Phenomenological Mathematical Modelling Framework for the Degradation of Bioresorbable Composites
LDR:03012nam a22004095i 4500 001 1013234
003 DE-He213
005 20200630164345.0
007 cr nn 008mamaa
008 210106s2019 gw | s |||| 0|eng d
020 $a 9783030049904 $9 978-3-030-04990-4
024 7 $a 10.1007/978-3-030-04990-4 $2 doi
035 $a 978-3-030-04990-4
050 4 $a R857.M3
072 7 $a TGM $2 bicssc
072 7 $a TEC021000 $2 bisacsh
072 7 $a TGM $2 thema
072 7 $a TCB $2 thema
082 0 4 $a 620.11 $2 23
100 1 $a Moreno-Gomez, Ismael. $e author. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1307535
245 1 2 $a A Phenomenological Mathematical Modelling Framework for the Degradation of Bioresorbable Composites $h [electronic resource] / $c by Ismael Moreno-Gomez.
250 $a 1st ed. 2019.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2019.
300 $a XLIII, 325 p. 383 illus., 262 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
490 1 $a Springer Theses, Recognizing Outstanding Ph.D. Research, $x 2190-5053
505 0 $a Introduction -- Literature review -- Degradation of bioresorbable composites: the models -- Degradation of bioresorbable composites: tricalcium phosphate case studies -- Degradation of bioresorbable composites: hydroxyapatite case studies -- Experimental degradation study of PLGA–CaCO3 nanocomposites -- Degradation of bioresorbable composites: calcium carbonate case studies -- Conclusions and future work -- Appendix.
520 $a This book presents a generalised computational model for the degradation of resorbable composites, using analytic expressions to represent the interwoven phenomena present during degradation. It then combines this modelling framework with a comprehensive database of quantitative degradation data mined from existing literature and from novel experiments, to provide new insights into the interrelated factors controlling degradation. Resorbable composites made of biodegradable polyesters and calcium-based ceramics have significant therapeutic potential as tissue engineering scaffolds, as temporary implants and as drug-loaded matrices for controlled release. However, their degradation is complex and the rate of resorption depends on multiple connected factors such as the shape and size of the device, polymer chemistry and molecular weight, particle phase, size, volume fraction, distribution and pH-dependent dissolution properties. Understanding and ultimately predicting the degradation of resorbable composites is of central importance if we are to fully unlock the promise of these materials.
650 0 $a Biomaterials. $3 677000
650 0 $a Physics. $3 564049
650 0 $a Materials science. $3 557839
650 2 4 $a Numerical and Computational Physics, Simulation. $3 1112293
650 2 4 $a Characterization and Evaluation of Materials. $3 674449
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783030049898
776 0 8 $i Printed edition: $z 9783030049911
830 0 $a Springer Theses, Recognizing Outstanding Ph.D. Research, $x 2190-5053 $3 1253569
856 4 0 $u https://doi.org/10.1007/978-3-030-04990-4
912 $a ZDB-2-CMS
912 $a ZDB-2-SXC
950 $a Chemistry and Materials Science (SpringerNature-11644)
950 $a Chemistry and Material Science (R0) (SpringerNature-43709)