國立虎尾科技大學 |

Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy/ by Dale Jonathan Waterhouse.
作者:	Waterhouse, Dale Jonathan.
面頁冊數:	XXI, 142 p.online resource. :
Contained By:	Springer Nature eBook
標題:	Medical physics. -
電子資源:	https://doi.org/10.1007/978-3-030-21481-4
ISBN:	9783030214814

Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy
Waterhouse, Dale Jonathan.

Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy[electronic resource] /by Dale Jonathan Waterhouse. - 1st ed. 2019. - XXI, 142 p.online resource. - Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053. - Springer Theses, Recognizing Outstanding Ph.D. Research,.

Translation of Optical Imaging Techniques -- Flexible Endoscopy: Early Detection of Dysplasia in Barrett’s Oesophagus -- Flexible Endoscopy : Device Architecture -- Flexible Endoscopy: Optical Molecular Imaging -- Flexible Endoscopy: Multispectral Imaging -- Rigid Endoscopy for Intraoperative Imaging of Pituitary Adenoma -- Conclusions and Outlook -- Appendix.

This thesis describes the design, development, characterisation and clinical translation of three novel devices for optical endoscopic imaging. Over the past decade, rapid innovation in optics and photonics has led to the availability of low-cost and high-performance optical technologies that can be exploited for biomedical applications, but relatively few have been translated into clinic. The work presented outlines for the first time, a comprehensive analysis of the common barriers and unique challenges associated with the translation of optical imaging techniques. To assist developers streamline translation of optical imaging devices in future, a roadmap to clinical translation is outlined, and key translational characteristics are defined. Guided by these, subsequent development of endoscopic devices resulted in preparation and approval of endoscopes for first in human trials in the oesophagus, for early detection of cancer, and in the brain, for delineation of tumour during surgical resection. The thesis culminates in the presentation of results from the first in human use of a compact multispectral endoscope for imaging endogenous tissue contrast in the oesophagus. With continuation of the work as outlined at the end of this thesis, the novel techniques described have the potential to improve the standard of care in their respective indications.

ISBN: 9783030214814

Standard No.: 10.1007/978-3-030-21481-4doiSubjects--Topical Terms:

588800
Medical physics.

LC Class. No.: QC474-496.9

Dewey Class. No.: 610.153

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