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Drug Transporters in Drug Disposition, Effects and Toxicity

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Drug Transporters in Drug Disposition, Effects and Toxicity/ edited by Xiaodong Liu, Guoyu Pan.
other author:	Liu, Xiaodong.
Description:	X, 580 p. 38 illus., 18 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Drug Safety and Pharmacovigilance. -
Online resource:	https://doi.org/10.1007/978-981-13-7647-4
ISBN:	9789811376474

Drug Transporters in Drug Disposition, Effects and Toxicity
Drug Transporters in Drug Disposition, Effects and Toxicity[electronic resource] /edited by Xiaodong Liu, Guoyu Pan. - 1st ed. 2019. - X, 580 p. 38 illus., 18 illus. in color.online resource. - Advances in Experimental Medicine and Biology,11410065-2598 ;. - Advances in Experimental Medicine and Biology,889.

Overview: role of drug transporters in drug disposition and its clinical significance -- ABC family transporters -- SLC family transporters -- Current research method in transporter study -- Transporter-mediated drug–drug interactions and their significance -- Roles of hepatic drug transporters in drug disposition and liver toxicity -- Roles of renal drug transporter in drug disposition and renal toxicity -- Intestinal transporter associated toxicity and absorption -- Contributions of drug transporters to blood-brain barriers -- Contributions of drug transporters to blood-retinal barrier(BRB) -- Contributions of drug transporters to blood-placental barrier -- ABC transporter-mediated multidrug-resistant cancer.

This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.

ISBN: 9789811376474

Standard No.: 10.1007/978-981-13-7647-4doiSubjects--Topical Terms:

1064651
Drug Safety and Pharmacovigilance.

LC Class. No.: RM1-950

Dewey Class. No.: 615

Drug Transporters in Drug Disposition, Effects and Toxicity
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