國立虎尾科技大學 |

Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems/ edited by Kevin L. Williams.
其他作者:	Williams, Kevin L.
面頁冊數:	XI, 869 p. 427 illus., 349 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Pharmaceutical technology. -
電子資源:	https://doi.org/10.1007/978-3-030-17148-3
ISBN:	9783030171483

Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems
Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems[electronic resource] /edited by Kevin L. Williams. - 1st ed. 2019. - XI, 869 p. 427 illus., 349 illus. in color.online resource.

Introduction -- Section I Pharma -- Historical Perspectives -- Risk, Control and Compliance. -- Sterility and Beyond -- LVPs and SMDs -- Specification Determination -- Static and Dynamic Models (Biodiversity and Heterogeneity) -- Test Development and Validation -- Diminishing Analytics -- Control in Biologics Manufacture -- Depyrogenation and Medical Devices -- Nanoparticles / Problematic Drug Types -- New Frontiers -- Section II Limulus -- Evolution, a Living Fossil and Other Model Arthropods -- Water, Water Everywhere -- Survival and Mass Extinction Events -- Limulus Soup / Hemolymph -- Is Innate Modeling Enough? -- A Foreboding -- Section III Mammalian -- Innate is Inborn -- The Host Response: Fever and Inflammation -- . Parallel Immune Systems: Architecture and Mechanisms -- Structural Change is Functional Change (Hand in Glove) -- Endotoxin and Adjuvanticity in Vaccinology -- Advances in Diagnostics -- The Big S.

Endotoxin detection and control is a dynamic area of applied science that touches a vast number of complex subjects. The intersection of test activities includes the use of an ancient blood system from an odd “living fossil” (Limulus). It is used to detect remnants of the most primitive and destructive forms of life (prokaryotes) as contaminants of complex modern systems (mammalian and Pharma). Recent challenges in the field include those associated with the application of traditional methods to new types of molecules and manufacturing processes. The advent of “at will” production of biologics in lieu of harvesting animal proteins has revolutionized the treatment of disease. While the fruits of the biotechnology revolution are widely acknowledged, the realization of the differences in the means of production and changes in the manner of control of potential impurities and contaminants in regard to the new versus the old are less widely appreciated. Endotoxin as an ancient, dynamic interface between lifeforms, provides a singular perspective from which to view the parallel development of ancient and modern organisms as well as the progress of man in deciphering the complexity of their interactions in his efforts to overcome disease.

ISBN: 9783030171483

Standard No.: 10.1007/978-3-030-17148-3doiSubjects--Topical Terms:

557391
Pharmaceutical technology.

LC Class. No.: RS380

Dewey Class. No.: 615.19

Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems
LDR:03610nam a22004095i 4500 001 1014570
003 DE-He213
005 20200702011159.0
007 cr nn 008mamaa
008 210106s2019 gw | s |||| 0|eng d
020 $a 9783030171483 $9 978-3-030-17148-3
024 7 $a 10.1007/978-3-030-17148-3 $2 doi
035 $a 978-3-030-17148-3
050 4 $a RS380
050 4 $a RS190-210
072 7 $a TDCW $2 bicssc
072 7 $a MED072000 $2 bisacsh
072 7 $a TDC $2 thema
082 0 4 $a 615.19 $2 23
245 1 0 $a Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems $h [electronic resource] / $c edited by Kevin L. Williams.
250 $a 1st ed. 2019.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2019.
300 $a XI, 869 p. 427 illus., 349 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
505 0 $a Introduction -- Section I Pharma -- Historical Perspectives -- Risk, Control and Compliance. -- Sterility and Beyond -- LVPs and SMDs -- Specification Determination -- Static and Dynamic Models (Biodiversity and Heterogeneity) -- Test Development and Validation -- Diminishing Analytics -- Control in Biologics Manufacture -- Depyrogenation and Medical Devices -- Nanoparticles / Problematic Drug Types -- New Frontiers -- Section II Limulus -- Evolution, a Living Fossil and Other Model Arthropods -- Water, Water Everywhere -- Survival and Mass Extinction Events -- Limulus Soup / Hemolymph -- Is Innate Modeling Enough? -- A Foreboding -- Section III Mammalian -- Innate is Inborn -- The Host Response: Fever and Inflammation -- . Parallel Immune Systems: Architecture and Mechanisms -- Structural Change is Functional Change (Hand in Glove) -- Endotoxin and Adjuvanticity in Vaccinology -- Advances in Diagnostics -- The Big S.
520 $a Endotoxin detection and control is a dynamic area of applied science that touches a vast number of complex subjects. The intersection of test activities includes the use of an ancient blood system from an odd “living fossil” (Limulus). It is used to detect remnants of the most primitive and destructive forms of life (prokaryotes) as contaminants of complex modern systems (mammalian and Pharma). Recent challenges in the field include those associated with the application of traditional methods to new types of molecules and manufacturing processes. The advent of “at will” production of biologics in lieu of harvesting animal proteins has revolutionized the treatment of disease. While the fruits of the biotechnology revolution are widely acknowledged, the realization of the differences in the means of production and changes in the manner of control of potential impurities and contaminants in regard to the new versus the old are less widely appreciated. Endotoxin as an ancient, dynamic interface between lifeforms, provides a singular perspective from which to view the parallel development of ancient and modern organisms as well as the progress of man in deciphering the complexity of their interactions in his efforts to overcome disease.
650 0 $a Pharmaceutical technology. $3 557391
650 0 $a Medical microbiology. $3 583124
650 1 4 $a Pharmaceutical Sciences/Technology. $3 768561
650 2 4 $a Medical Microbiology. $3 668401
700 1 $a Williams, Kevin L. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1229005
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783030171476
776 0 8 $i Printed edition: $z 9783030171490
776 0 8 $i Printed edition: $z 9783030171506
856 4 0 $u https://doi.org/10.1007/978-3-030-17148-3
912 $a ZDB-2-SBL
912 $a ZDB-2-SXB
950 $a Biomedical and Life Sciences (SpringerNature-11642)
950 $a Biomedical and Life Sciences (R0) (SpringerNature-43708)