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Minimal Cells: Design, Construction, Biotechnological Applications

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Minimal Cells: Design, Construction, Biotechnological Applications/ edited by Alvaro R. Lara, Guillermo Gosset.
其他作者:	Gosset, Guillermo.
面頁冊數:	VII, 230 p. 35 illus., 29 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Cell Biology. -
電子資源:	https://doi.org/10.1007/978-3-030-31897-0
ISBN:	9783030318970

Minimal Cells: Design, Construction, Biotechnological Applications
Minimal Cells: Design, Construction, Biotechnological Applications[electronic resource] /edited by Alvaro R. Lara, Guillermo Gosset. - 1st ed. 2020. - VII, 230 p. 35 illus., 29 illus. in color.online resource.

Reduced and Minimal Cell Factories in Bioprocesses: Towards a Streamlined Chassis -- Construction of minimal genomes and synthetic cells -- Engineering reduced-genome strains of Pseudomonas putida for product valorization -- Genome-reduced Corynebacterium glutamicum fit for biotechnological applications -- Reduction of the Saccharomyces cerevisiae genome: challenges and perspectives -- The use of in silico genome-scale models for the rational design of minimal cells -- From minimal to minimized genomes: Functional design of microbial cell factories -- Resource allocation principles and minimal cell design.

This book provides a comprehensive overview of the design, generation and characterization of minimal cell systems. Written by leading experts, it presents an in-depth analysis of the current issues and challenges in the field, including recent advances in the generation and characterization of reduced-genome strains generated from model organisms with relevance in biotechnology, and basic research such as Escherichia coli, Corynebacterium glutamicum and yeast. It also discusses methodologies, such as bottom-up and top-down genome minimization strategies, as well as novel analytical and experimental approaches to characterize and generate minimal cells. Lastly, it presents the latest research related to minimal cells of serveral microorganisms, e.g. Bacillus subtilis. The design of biological systems for biotechnological purposes employs strategies aimed at optimizing specific tasks. This approach is based on enhancing certain biological functions while reducing other capacities that are not required or that could be detrimental to the desired objective. A highly optimized cell factory would be expected to have only the capacity for reproduction and for performing the expected task. Such a hypothetical organism would be considered a minimal cell. At present, numerous research groups in academia and industry are exploring the theoretical and practical implications of constructing and using minimal cells and are providing valuable fundamental insights into the characteristics of minimal genomes, leading to an understanding of the essential gene set. In addition, research in this field is providing valuable information on the physiology of minimal cells and their utilization as a biological chassis to which useful biotechnological functions can be added.

ISBN: 9783030318970

Standard No.: 10.1007/978-3-030-31897-0doiSubjects--Topical Terms:

593889
Cell Biology.

LC Class. No.: QR1-502

Dewey Class. No.: 579

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