國立虎尾科技大學 |

Mammalian Sterols = Novel Biological Roles of Cholesterol Synthesis Intermediates, Oxysterols and Bile Acids /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Mammalian Sterols / edited by Damjana Rozman, Rolf Gebhardt.
Reminder of title:	Novel Biological Roles of Cholesterol Synthesis Intermediates, Oxysterols and Bile Acids /
other author:	Rozman, Damjana.
Description:	V, 171 p. 57 illus., 14 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Molecular biology. -
Online resource:	https://doi.org/10.1007/978-3-030-39684-8
ISBN:	9783030396848

Mammalian Sterols = Novel Biological Roles of Cholesterol Synthesis Intermediates, Oxysterols and Bile Acids /
Mammalian Sterols Novel Biological Roles of Cholesterol Synthesis Intermediates, Oxysterols and Bile Acids /[electronic resource] :edited by Damjana Rozman, Rolf Gebhardt. - 1st ed. 2020. - V, 171 p. 57 illus., 14 illus. in color.online resource.

Sterols from the post-lanosterol part of cholesterol synthesis – novel signaling players -- Genetic variability in cholesterol metabolism -- Side-chain oxidized oxysterols in health and disease -- Bile acids and TGR5 (Gpbar1) signaling -- Bile acids as regulatory signalling molecules -- Oxysterols and bile acid act as signaling molecules that regulate cholesterol homeostasis: nuclear receptors LXR, FXR, and fibroblast growth factor 15/19 -- Cytochrome P450 Metabolism Leads to Novel Biological Sterols and Other Steroids.

This book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as medical doctors in hepatology.

ISBN: 9783030396848

Standard No.: 10.1007/978-3-030-39684-8doiSubjects--Topical Terms:

583443
Molecular biology.

LC Class. No.: QH506

Dewey Class. No.: 611.01816

Mammalian Sterols = Novel Biological Roles of Cholesterol Synthesis Intermediates, Oxysterols and Bile Acids /
LDR:02951nam a22004095i 4500 001 1021716
003 DE-He213
005 20200810204754.0
007 cr nn 008mamaa
008 210318s2020 gw | s |||| 0|eng d
020 $a 9783030396848 $9 978-3-030-39684-8
024 7 $a 10.1007/978-3-030-39684-8 $2 doi
035 $a 978-3-030-39684-8
050 4 $a QH506
072 7 $a MBGR $2 bicssc
072 7 $a SCI049000 $2 bisacsh
072 7 $a MBGR $2 thema
072 7 $a PSD $2 thema
082 0 4 $a 611.01816 $2 23
245 1 0 $a Mammalian Sterols $h [electronic resource] : $b Novel Biological Roles of Cholesterol Synthesis Intermediates, Oxysterols and Bile Acids / $c edited by Damjana Rozman, Rolf Gebhardt.
250 $a 1st ed. 2020.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2020.
300 $a V, 171 p. 57 illus., 14 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
505 0 $a Sterols from the post-lanosterol part of cholesterol synthesis – novel signaling players -- Genetic variability in cholesterol metabolism -- Side-chain oxidized oxysterols in health and disease -- Bile acids and TGR5 (Gpbar1) signaling -- Bile acids as regulatory signalling molecules -- Oxysterols and bile acid act as signaling molecules that regulate cholesterol homeostasis: nuclear receptors LXR, FXR, and fibroblast growth factor 15/19 -- Cytochrome P450 Metabolism Leads to Novel Biological Sterols and Other Steroids.
520 $a This book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as medical doctors in hepatology.
650 0 $a Molecular biology. $3 583443
650 0 $a Biochemistry. $3 582831
650 0 $a Hepatology. $3 673859
650 0 $a Lipids. $3 556565
650 0 $a Metabolism. $3 581368
650 0 $a Human genetics. $3 596505
650 1 4 $a Molecular Medicine. $3 668353
650 2 4 $a Animal Biochemistry. $3 668644
650 2 4 $a Lipidology. $3 681911
650 2 4 $a Metabolomics. $3 882386
650 2 4 $a Human Genetics. $3 593893
700 1 $a Rozman, Damjana. $e editor. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1317404
700 1 $a Gebhardt, Rolf. $e editor. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1317405
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783030396831
776 0 8 $i Printed edition: $z 9783030396855
776 0 8 $i Printed edition: $z 9783030396862
856 4 0 $u https://doi.org/10.1007/978-3-030-39684-8
912 $a ZDB-2-SBL
912 $a ZDB-2-SXB
950 $a Biomedical and Life Sciences (SpringerNature-11642)
950 $a Biomedical and Life Sciences (R0) (SpringerNature-43708)