國立虎尾科技大學 |

The M2 Macrophage

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The M2 Macrophage/ by Tamás Röszer.
Author:	Röszer, Tamás.
Description:	XIII, 224 p. 56 illus., 49 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Immunology. -
Online resource:	https://doi.org/10.1007/978-3-030-50480-9
ISBN:	9783030504809

The M2 Macrophage
Röszer, Tamás.

The M2 Macrophage[electronic resource] /by Tamás Röszer. - 1st ed. 2020. - XIII, 224 p. 56 illus., 49 illus. in color.online resource. - Progress in Inflammation Research,860379-0363 ;. - Progress in Inflammation Research,.

Chapter 1. Introduction. What is an M2 macrophage? Historical overview of the macrophage polarization model. The Th1/Th2 and M1/M2 paradigms, the arginine fork -- Chapter 2. Evolutionary origin of the M2 macrophage activation: invertebrates -- Chapter 3. Evolution of M2 macrophage functions in chordates -- Chapter 4. Signal mechanisms of M2 macrophage activation -- Chapter 5. Mechanisms which control the size of M2 macrophage-dominated tissue macrophage niches -- Chapter 6.Immune functions of the M2 macrophages: host defense, self-tolerance and autoimmunity -- Chapter 7. M2 macrophages in the integument and in the musculoskeletal system -- Chapter 8. M2 macrophages in the circulatory-, respiratory and excretory organs -- Chapter 9. M2 macrophages in the metabolic organs and in the neuroendocrine system -- Chapter 10. Practical approaches in M2 macrophage biology: analysis, pharmacology and didactical interpretation of M2 macrophage functions.

Macrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of immunity, tissue development and turnover, metabolism, and endocrine signaling. Dysfunction in M2 macrophages can ruin the healthy interplay between the immune system and metabolic processes, and lead to diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Furthermore, M2 macrophages are essential for healthy tissue development and immunological self-tolerance. Worryingly, these functions of M2 macrophages can also be disrupted, resulting in tumor growth and autoimmunity. This book comprehensively discusses the biology of M2 macrophages, summarizes the current state of knowledge, and highlights key questions that remain unanswered.

ISBN: 9783030504809

Standard No.: 10.1007/978-3-030-50480-9doiSubjects--Topical Terms:

592892
Immunology.

LC Class. No.: QR180-189.5

Dewey Class. No.: 616.079

The M2 Macrophage
LDR:03587nam a22004095i 4500 001 1021817
003 DE-He213
005 20200803060327.0
007 cr nn 008mamaa
008 210318s2020 gw | s |||| 0|eng d
020 $a 9783030504809 $9 978-3-030-50480-9
024 7 $a 10.1007/978-3-030-50480-9 $2 doi
035 $a 978-3-030-50480-9
050 4 $a QR180-189.5
072 7 $a MJCM $2 bicssc
072 7 $a MED044000 $2 bisacsh
072 7 $a MJCM $2 thema
082 0 4 $a 616.079 $2 23
100 1 $a Röszer, Tamás. $e author. $4 aut $4 http://id.loc.gov/vocabulary/relators/aut $3 1317504
245 1 4 $a The M2 Macrophage $h [electronic resource] / $c by Tamás Röszer.
250 $a 1st ed. 2020.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2020.
300 $a XIII, 224 p. 56 illus., 49 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
490 1 $a Progress in Inflammation Research, $x 0379-0363 ; $v 86
505 0 $a Chapter 1. Introduction. What is an M2 macrophage? Historical overview of the macrophage polarization model. The Th1/Th2 and M1/M2 paradigms, the arginine fork -- Chapter 2. Evolutionary origin of the M2 macrophage activation: invertebrates -- Chapter 3. Evolution of M2 macrophage functions in chordates -- Chapter 4. Signal mechanisms of M2 macrophage activation -- Chapter 5. Mechanisms which control the size of M2 macrophage-dominated tissue macrophage niches -- Chapter 6.Immune functions of the M2 macrophages: host defense, self-tolerance and autoimmunity -- Chapter 7. M2 macrophages in the integument and in the musculoskeletal system -- Chapter 8. M2 macrophages in the circulatory-, respiratory and excretory organs -- Chapter 9. M2 macrophages in the metabolic organs and in the neuroendocrine system -- Chapter 10. Practical approaches in M2 macrophage biology: analysis, pharmacology and didactical interpretation of M2 macrophage functions.
520 $a Macrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of immunity, tissue development and turnover, metabolism, and endocrine signaling. Dysfunction in M2 macrophages can ruin the healthy interplay between the immune system and metabolic processes, and lead to diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Furthermore, M2 macrophages are essential for healthy tissue development and immunological self-tolerance. Worryingly, these functions of M2 macrophages can also be disrupted, resulting in tumor growth and autoimmunity. This book comprehensively discusses the biology of M2 macrophages, summarizes the current state of knowledge, and highlights key questions that remain unanswered.
650 0 $a Immunology. $3 592892
650 0 $a Cell biology. $3 1253486
650 0 $a Lipids. $3 556565
650 0 $a Infectious diseases. $3 1102043
650 0 $a Human physiology. $3 636012
650 2 4 $a Cell Biology. $3 593889
650 2 4 $a Lipidology. $3 681911
650 2 4 $a Infectious Diseases. $3 668393
650 2 4 $a Human Physiology. $3 668349
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783030504793
776 0 8 $i Printed edition: $z 9783030504816
776 0 8 $i Printed edition: $z 9783030504823
830 0 $a Progress in Inflammation Research, $x 0379-0363 $3 1257722
856 4 0 $u https://doi.org/10.1007/978-3-030-50480-9
912 $a ZDB-2-SBL
912 $a ZDB-2-SXB
950 $a Biomedical and Life Sciences (SpringerNature-11642)
950 $a Biomedical and Life Sciences (R0) (SpringerNature-43708)