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Drug Discovery and Evaluation: Methods in Clinical Pharmacology

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Drug Discovery and Evaluation: Methods in Clinical Pharmacology/ edited by Franz J. Hock, Michael R. Gralinski.
其他作者:	Gralinski, Michael R.
面頁冊數:	online resource. :
Contained By:	Springer Nature Living Reference
標題:	Medical Biochemistry. -
電子資源:	https://doi.org/10.1007/978-3-319-56637-5
ISBN:	9783319566375

Drug Discovery and Evaluation: Methods in Clinical Pharmacology
Drug Discovery and Evaluation: Methods in Clinical Pharmacology[electronic resource] /edited by Franz J. Hock, Michael R. Gralinski. - online resource.

DDrug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology". For the 2nd edition, all the existing chapters will be revised and completely updated. A large number of assays were added. New chapters were included, such as pain, addiction, gene therapy, orphan diseases etc. etc. The complete work was new arranged.

ISBN: 9783319566375

Standard No.: 10.1007/978-3-319-56637-5doiSubjects--Topical Terms:

668897
Medical Biochemistry.

LC Class. No.: RM1-950

Dewey Class. No.: 615

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