國立虎尾科技大學 |

Total Synthesis of Indole Alkaloids = Based on Direct Construction of Pyrrolocarbazole Scaffolds via Gold-Catalyzed Cascade Cyclizations /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Total Synthesis of Indole Alkaloids/ by Junpei Matsuoka.
其他題名:	Based on Direct Construction of Pyrrolocarbazole Scaffolds via Gold-Catalyzed Cascade Cyclizations /
作者:	Matsuoka, Junpei.
面頁冊數:	XII, 82 p. 77 illus., 4 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Pharmaceutical Sciences/Technology. -
電子資源:	https://doi.org/10.1007/978-981-15-8652-1
ISBN:	9789811586521

Total Synthesis of Indole Alkaloids = Based on Direct Construction of Pyrrolocarbazole Scaffolds via Gold-Catalyzed Cascade Cyclizations /
Matsuoka, Junpei.

Total Synthesis of Indole AlkaloidsBased on Direct Construction of Pyrrolocarbazole Scaffolds via Gold-Catalyzed Cascade Cyclizations /[electronic resource] :by Junpei Matsuoka. - 1st ed. 2020. - XII, 82 p. 77 illus., 4 illus. in color.online resource. - Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5053. - Springer Theses, Recognizing Outstanding Ph.D. Research,.

1. Introduction -- 2. Total Synthesis of Dictyodendrin A–F by the Gold-Catalyzed Cascade Cyclization of Conjugated Diynes with Pyrroles -- 3. Construction of the Pyrrolo[2,3-d]carbazole Core of Spiroindoline Alkaloids by Gold-Catalyzed Cascade Cyclization of Ynamide.

This book explores efficient syntheses of indole alkaloids based on gold-catalyzed cascade cyclizations, presenting two strategies for total synthesis of these natural products based on gold-catalyzed reactions of conjugated diyne or ynamide. The book first describes the total and formal synthesis of dictyodendrins A–F based on direct construction of the pyrrolo[2,3-c]carbazole core using the gold-catalyzed annulation of azido-diynes and protected pyrrole. This synthetic strategy features late-stage functionalization of the pyrrolo[2,3-c]carbazole scaffold at several positions and allows diverse access to dictyodendrins and their derivatives. Secondly, the book discusses the formal synthesis of vindorosine based on the pyrrolo[2,3-d]carbazole construction using the gold-catalyzed cascade cyclization of ynamide. Importantly, the reaction using a chiral gold complex provides the optically active pyrrolo[2,3-d]carbazole. This strategy facilitates the rapid construction of the pyrrolocarbazole core structure of aspidosperma and related alkaloids, including vindorosine. These methodologies can accelerate the medicinal application of pyrrolocarbazole-type alkaloids and related compounds.

ISBN: 9789811586521

Standard No.: 10.1007/978-981-15-8652-1doiSubjects--Topical Terms:

768561
Pharmaceutical Sciences/Technology.

LC Class. No.: QD415-436

Dewey Class. No.: 547

Total Synthesis of Indole Alkaloids = Based on Direct Construction of Pyrrolocarbazole Scaffolds via Gold-Catalyzed Cascade Cyclizations /
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