國立虎尾科技大學 |

Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing = A Big Chapter in the Tale /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing/ edited by Khalid El Bairi.
其他題名:	A Big Chapter in the Tale /
其他作者:	El Bairi, Khalid.
面頁冊數:	XV, 185 p. 26 illus., 25 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Genetics and Genomics. -
電子資源:	https://doi.org/10.1007/978-3-030-53821-7
ISBN:	9783030538217

Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing = A Big Chapter in the Tale /
Illuminating Colorectal Cancer Genomics by Next-Generation SequencingA Big Chapter in the Tale /[electronic resource] :edited by Khalid El Bairi. - 1st ed. 2020. - XV, 185 p. 26 illus., 25 illus. in color.online resource.

An Introduction to the Current Management of Colorectal Cancer in the Era of Personalized Oncology -- Colorectal Cancer Genetics: An Overview of the Actionable Building Blocks -- The Arrival of Next-Generation Sequencing: An Overview of Current Technologies -- Next-Generation Sequencing for Colorectal Cancer Management -- Gut Microbiota, Next-Generation Sequencing, Immune Checkpoint Inhibitors and Colorectal Cancer: How Hot is the Link? -- The Revolution of Liquid Biopsy and Single-Cell Sequencing in the Management of Colorectal Cancer -- Overview of Cost-Effectiveness and Limitations of Next-Generation Sequencing in Colorectal Cancer.

This book reviews the potential of next-generation sequencing (NGS) in research on and management of colorectal cancer (CRC), a leading cause of death worldwide and one of the most biologically and clinically heterogeneous cancers. It critically discusses findings from recent large-scale studies, clinical trials and meta-analyses and offers an introduction to the management of CRC in the era of precision medicine. In CRC, dozens of driver and passenger mutations are associated with the malignant transformation of epithelial cells. Consequently, the book discusses recent advances in our understanding of the genetics of CRC as a biomarker, the advent of NGS technologies in modern genomics, and the impact of NGS technology on the management of CRC. Furthermore, it highlights the potential of NGS in the context of liquid biopsy and single-cell sequencing in CRC, as well as its role in shedding light on the link between gut microbiota, immune-checkpoint blockade and CRC. The book concludes with a chapter on the limitations and cost-effectiveness of NGS in CRC. Given its scope, the book will appeal to all those interested in learning about the potential of NGS in advancing CRC research and patient care. .

ISBN: 9783030538217

Standard No.: 10.1007/978-3-030-53821-7doiSubjects--Topical Terms:

1229010
Genetics and Genomics.

LC Class. No.: RC261-271

Dewey Class. No.: 614.5999

Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing = A Big Chapter in the Tale /
LDR:03282nam a22003975i 4500 001 1029771
003 DE-He213
005 20200928091708.0
007 cr nn 008mamaa
008 210318s2020 gw | s |||| 0|eng d
020 $a 9783030538217 $9 978-3-030-53821-7
024 7 $a 10.1007/978-3-030-53821-7 $2 doi
035 $a 978-3-030-53821-7
050 4 $a RC261-271
072 7 $a MJCL $2 bicssc
072 7 $a MED062000 $2 bisacsh
072 7 $a MJCL $2 thema
082 0 4 $a 614.5999 $2 23
245 1 0 $a Illuminating Colorectal Cancer Genomics by Next-Generation Sequencing $h [electronic resource] : $b A Big Chapter in the Tale / $c edited by Khalid El Bairi.
250 $a 1st ed. 2020.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2020.
300 $a XV, 185 p. 26 illus., 25 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
505 0 $a An Introduction to the Current Management of Colorectal Cancer in the Era of Personalized Oncology -- Colorectal Cancer Genetics: An Overview of the Actionable Building Blocks -- The Arrival of Next-Generation Sequencing: An Overview of Current Technologies -- Next-Generation Sequencing for Colorectal Cancer Management -- Gut Microbiota, Next-Generation Sequencing, Immune Checkpoint Inhibitors and Colorectal Cancer: How Hot is the Link? -- The Revolution of Liquid Biopsy and Single-Cell Sequencing in the Management of Colorectal Cancer -- Overview of Cost-Effectiveness and Limitations of Next-Generation Sequencing in Colorectal Cancer.
520 $a This book reviews the potential of next-generation sequencing (NGS) in research on and management of colorectal cancer (CRC), a leading cause of death worldwide and one of the most biologically and clinically heterogeneous cancers. It critically discusses findings from recent large-scale studies, clinical trials and meta-analyses and offers an introduction to the management of CRC in the era of precision medicine. In CRC, dozens of driver and passenger mutations are associated with the malignant transformation of epithelial cells. Consequently, the book discusses recent advances in our understanding of the genetics of CRC as a biomarker, the advent of NGS technologies in modern genomics, and the impact of NGS technology on the management of CRC. Furthermore, it highlights the potential of NGS in the context of liquid biopsy and single-cell sequencing in CRC, as well as its role in shedding light on the link between gut microbiota, immune-checkpoint blockade and CRC. The book concludes with a chapter on the limitations and cost-effectiveness of NGS in CRC. Given its scope, the book will appeal to all those interested in learning about the potential of NGS in advancing CRC research and patient care. .
650 2 4 $a Genetics and Genomics. $3 1229010
650 1 4 $a Cancer Research. $3 668358
650 0 $a Genetics. $3 578972
650 0 $a Cancer research. $3 1253664
700 1 $a El Bairi, Khalid. $e editor. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1326585
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783030538200
776 0 8 $i Printed edition: $z 9783030538224
776 0 8 $i Printed edition: $z 9783030538231
856 4 0 $u https://doi.org/10.1007/978-3-030-53821-7
912 $a ZDB-2-SBL
912 $a ZDB-2-SXB
950 $a Biomedical and Life Sciences (SpringerNature-11642)
950 $a Biomedical and Life Sciences (R0) (SpringerNature-43708)