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Feasibility of Using Nanocomposite Polyethylene Glycol Hydrogels Containing Zinc Oxide and/or Carbon Nanotubes as Neural Substrates.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Feasibility of Using Nanocomposite Polyethylene Glycol Hydrogels Containing Zinc Oxide and/or Carbon Nanotubes as Neural Substrates./
Author:	Hutchinson, Brannan E.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	70 p.
Notes:	Source: Masters Abstracts International, Volume: 82-04.
Contained By:	Masters Abstracts International82-04.
Subject:	Biomedical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28087448
ISBN:	9798672151915

Feasibility of Using Nanocomposite Polyethylene Glycol Hydrogels Containing Zinc Oxide and/or Carbon Nanotubes as Neural Substrates.
Hutchinson, Brannan E.

Feasibility of Using Nanocomposite Polyethylene Glycol Hydrogels Containing Zinc Oxide and/or Carbon Nanotubes as Neural Substrates. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 70 p.

Source: Masters Abstracts International, Volume: 82-04.

Thesis (M.S.)--Saint Louis University, 2020.

This item must not be sold to any third party vendors.

Carbon nanotube (CNT)-polyethylene glycol (PEG) hydrogel composites have shown great potential as substrates for neural tissue engineering. Hydrogels mimic the extracellular matrix due to their hydrophilicity, viscoelasticity and biocompatibility, and CNTs impart electroconductivity, improve mechanical stability and can provide directional guidance for axon regeneration. In this study, we explore adding powdered zinc oxide (ZnO) to PEG hydrogels to either replace or use in combination with CNTs. We chose ZnO, because it is a semi-conductive and piezoelectric nanoparticle that has also shown promising anti-bacterial and anti-cancer activity properties when used as a dispersed powder in solution. While ZnO in medium has shown to be somewhat toxic towards most mammalian cell lines including neurons, little is known of the effects of ZnO entrapped in hydrogel scaffolds. Here, we explored neural-like PC12 cell behavior when seeded on different concentrations of ZnO-PEG hydrogels (0-100 µg/mL) and CNT imprinted ZnO-PEG hydrogels. We determined that low ZnO concentrations in PEG gels could support cell adhesion, viability and spreading than PEG only gels, and that imprinting CNTs improved cell adhesion, viability and spreading even further. Higher concentrations of ZnO (100 µg/mL) were toxic to cells even when embedded in the PEG gels. Our feasibility studies show that hybrid CNT imprinted ZnO hydrogels, where ZnO is kept at a low concentration, could be suitable neural substrates that merit further investigation.

ISBN: 9798672151915Subjects--Topical Terms:

588770
Biomedical engineering.
Subjects--Index Terms:

Carbon Nanotubes

Feasibility of Using Nanocomposite Polyethylene Glycol Hydrogels Containing Zinc Oxide and/or Carbon Nanotubes as Neural Substrates.
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520 $a Carbon nanotube (CNT)-polyethylene glycol (PEG) hydrogel composites have shown great potential as substrates for neural tissue engineering. Hydrogels mimic the extracellular matrix due to their hydrophilicity, viscoelasticity and biocompatibility, and CNTs impart electroconductivity, improve mechanical stability and can provide directional guidance for axon regeneration. In this study, we explore adding powdered zinc oxide (ZnO) to PEG hydrogels to either replace or use in combination with CNTs. We chose ZnO, because it is a semi-conductive and piezoelectric nanoparticle that has also shown promising anti-bacterial and anti-cancer activity properties when used as a dispersed powder in solution. While ZnO in medium has shown to be somewhat toxic towards most mammalian cell lines including neurons, little is known of the effects of ZnO entrapped in hydrogel scaffolds. Here, we explored neural-like PC12 cell behavior when seeded on different concentrations of ZnO-PEG hydrogels (0-100 µg/mL) and CNT imprinted ZnO-PEG hydrogels. We determined that low ZnO concentrations in PEG gels could support cell adhesion, viability and spreading than PEG only gels, and that imprinting CNTs improved cell adhesion, viability and spreading even further. Higher concentrations of ZnO (100 µg/mL) were toxic to cells even when embedded in the PEG gels. Our feasibility studies show that hybrid CNT imprinted ZnO hydrogels, where ZnO is kept at a low concentration, could be suitable neural substrates that merit further investigation.
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