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Neuroprotection in Alzheimer's disease
~
Gozes, Illana,
Neuroprotection in Alzheimer's disease
紀錄類型:
書目-語言資料,印刷品 : Monograph/item
正題名/作者:
Neuroprotection in Alzheimer's disease/ edited by Illana Gozes.
其他作者:
Gozes, Illana,
出版者:
London, United Kingdom :Academic Press, : 2017.,
面頁冊數:
1 online resource
標題:
MEDICAL - Internal Medicine. -
電子資源:
https://www.sciencedirect.com/science/book/9780128036907
ISBN:
9780128037126 (electronic bk.)
Neuroprotection in Alzheimer's disease
Neuroprotection in Alzheimer's disease
[electronic resource] /edited by Illana Gozes. - London, United Kingdom :Academic Press,2017. - 1 online resource
Cover; Title page; Copyright Page; Dedication; Contents; List of Contributors; Acknowledgments; Chapter 1 -- Introduction; Chapter 2 -- Neural Regeneration as a Disease-Modifying Therapeutic Strategy for Alzheimer's Disease; Introduction; Global health care burden of Alzheimer's disease: epidemiological data; Etiopathogenesis of Alzheimer's disease: what do we know?; Therapeutic approaches to Alzheimer's disease: the promises, the failures, and the future; Neural regeneration-based therapeutic approach for AD: the rationale, the promise, and the progress.
ISBN: 9780128037126 (electronic bk.)Subjects--Topical Terms:
862781
MEDICAL
--Internal Medicine.Index Terms--Genre/Form:
1344909
Internet Resources.
LC Class. No.: RC523
Dewey Class. No.: 616.8/311
National Library of Medicine Call No.: 2017 D-046
Neuroprotection in Alzheimer's disease
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Neurotrophic factor small-molecule mimetics for Alzheimer's diseaseEnhancement of neurogenesis and memory by CNTF small-molecule mimetics; CNTF-derived neurogenic/neurotrophic compound, P021, can exert a disease-modifying effect in a transgenic mouse model of AD; Summary and conclusions; References; Chapter 3 -- Animal Models of Alzheimer's Disease; Introduction; The genetics of Alzheimer's disease; Transgenic models of amyloidogenesis; Amyloid precursor protein transgenic mice; PDAPP transgenic mice; Histopathology; Behavior; Synaptic Plasticity; Tg2576 transgenic mice; Histopathology.
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BehaviorSynaptic Plasticity; APP23 transgenic mice; Histopathology; Behavior; Synaptic Plasticity; J20 transgenic mice; Histopathology; Behavior; Synaptic Plasticity; APP knock-in transgenic mice; Histopathology; Behavior; Synaptic Plasticity; APP/PS1 transgenic mice; Histopathology; Behavior; Synaptic Plasticity; 5xFAD transgenic mice; Histopathology; Behavior; Synaptic Plasticity; Tau transgenic mice; Tau tg mice under tau promoter; Histopathology; Behavior; Synaptic Plasticity; 3xTg transgenic mice; Histopathology; Behavior; Synaptic Plasticity; Animal models for late onset of AD.
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ApoE Transgenic MiceApoE Knock-Out Transgenic Mice; ApoE2/ApoE3/ApoE4 Knock-In Transgenic Mice; GFAP-ApoE4/ApoE Knock-Out Transgenic Mice; ApoE/APP Transgenic Mice; Nonmouse models; Studies in nematodes; Studies in fruit flies; Nontransgenic models for the study of AD; How to choose the right model?; Summary; Acknowledgment; References; Chapter 4 -- Mechanisms of Neuronal Microtubule Loss in Alzheimer's Disease; Introduction; Studies on Alzheimer's brain and animal models; Are microtubules destabilized in the Alzheimer's brain?; Mechanisms of microtubule loss in the Alzheimer's brain.
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Strategies for treatmentAcknowledgments; References; Chapter 5 -- Tau-Centric Therapies for Treating Alzheimer's Disease; Introduction; Six Tau Isoforms-Many Tau Functions; Mechanisms of Tau Toxicity: Phosphorylation, Microtubule Destabilization, and Aggregation; Tau-centric therapeutic strategy 1: targeting tau phosphorylation; Tau Phosphorylation in Physiological and Pathological States; Mechanisms for Stimulating Tau Phosphorylation; Consequences of Phosphorylation; Therapeutic Strategies to Inhibit Tau Phosphorylation; Current State of Affairs.
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https://www.sciencedirect.com/science/book/9780128036907
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