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RNA Damage and Repair

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	RNA Damage and Repair/ edited by Ioly Kotta-Loizou.
其他作者:	Kotta-Loizou, Ioly.
面頁冊數:	IX, 178 p. 25 illus., 22 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Nucleic acids. -
電子資源:	https://doi.org/10.1007/978-3-030-76571-2
ISBN:	9783030765712

RNA Damage and Repair
RNA Damage and Repair[electronic resource] /edited by Ioly Kotta-Loizou. - 1st ed. 2021. - IX, 178 p. 25 illus., 22 illus. in color.online resource.

Part 1: RNA Damage and Repair in Prokaryotes -- Chapter 1: Endoribonucleases of the toxin-antitoxin systems induce abortive infection -- Chapter 2: The lifecycle of ribosomal RNA in bacteria -- Chapter 3: The Rtc RNA end healing and sealing system -- Part 2: RNA Damage and Repair in Eukaryotes -- Chapter 4: Oxidative and nitrative RNA modifications in plants -- Chapter 5: The role of ribonucleases in RNA damage, inactivation, and degradation -- Chapter 6: Cytoplasmic mRNA recapping: An unexpected form of RNA repair -- Part 3: RNA Damage in Human Diseases -- Chapter 7: Adenosine-to-Inosine RNA editing: a key RNA processing step rewriting transcriptome in normal physiology and diseases -- Chapter 8: RNA-mediated metabolic defects in microsatellite expansion diseases.

Ribonucleic acid (RNA) is a macromolecule that plays a central role in cell physiology: RNA molecules act as intermediates between the deoxyribonucleic acid (DNA), where genetic information is stored, and proteins, which perform the necessary functions within the cell. Traditionally, the structural and functional properties of RNA are closely linked to gene expression. However, RNA-based enzymes, called ribozymes, are also involved in catalysis and small RNAs regulate key cellular processes, such as cell growth, division, differentiation, aging and death. RNA is a sensitive macromolecule that can be easily damaged by environmental conditions (ultraviolet radiation, oxidative stress) and biological factors (ribonucleases, ribotoxins, CRISPR-Cas systems). Therefore, cells have developed mechanisms to protect and/or repair RNA molecules. This book presents an overview of the biology of RNA damage, protection and repair in prokaryotes and eukaryotes. Individual chapters cover the expression regulation, enzymology and physiological role of such systems, and link them to important human diseases such as cancer and degenerative diseases.

ISBN: 9783030765712

Standard No.: 10.1007/978-3-030-76571-2doiSubjects--Topical Terms:

788506
Nucleic acids.

LC Class. No.: QD433-436

Dewey Class. No.: 572.84

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520 $a Ribonucleic acid (RNA) is a macromolecule that plays a central role in cell physiology: RNA molecules act as intermediates between the deoxyribonucleic acid (DNA), where genetic information is stored, and proteins, which perform the necessary functions within the cell. Traditionally, the structural and functional properties of RNA are closely linked to gene expression. However, RNA-based enzymes, called ribozymes, are also involved in catalysis and small RNAs regulate key cellular processes, such as cell growth, division, differentiation, aging and death. RNA is a sensitive macromolecule that can be easily damaged by environmental conditions (ultraviolet radiation, oxidative stress) and biological factors (ribonucleases, ribotoxins, CRISPR-Cas systems). Therefore, cells have developed mechanisms to protect and/or repair RNA molecules. This book presents an overview of the biology of RNA damage, protection and repair in prokaryotes and eukaryotes. Individual chapters cover the expression regulation, enzymology and physiological role of such systems, and link them to important human diseases such as cancer and degenerative diseases.
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