國立虎尾科技大學 |

Locoregional Radionuclide Cancer Therapy = Clinical and Scientific Aspects /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Locoregional Radionuclide Cancer Therapy/ edited by Franklin C.L. Wong.
Reminder of title:	Clinical and Scientific Aspects /
other author:	Wong, Franklin C.L.
Description:	XII, 268 p. 76 illus., 56 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Nuclear medicine. -
Online resource:	https://doi.org/10.1007/978-3-030-56267-0
ISBN:	9783030562670

Locoregional Radionuclide Cancer Therapy = Clinical and Scientific Aspects /
Locoregional Radionuclide Cancer TherapyClinical and Scientific Aspects /[electronic resource] :edited by Franklin C.L. Wong. - 1st ed. 2021. - XII, 268 p. 76 illus., 56 illus. in color.online resource.

Human Cancer- Epidemiology, Hallmarks, and Defense Strategies -- Cancer Treatment Modalities Systemic and Loco regional Approaches: Challenges and Opportunities of multidisciplinary approaches -- Cancer Radiotherapy: General Considerations and Human Radiobiology -- Radionuclide Cancer Therapy- Unsealed Alpha, Beta and Gamma Emitters -- Locoregional Therapy – Cancer Interventions with and without Radionuclides -- Radiation Dosimetry Considerations of Locoregional Radionuclide Cancer Therapy -- Voxel-based Targeted Radionuclide Therapy Dosimetry -- Locoregional Unsealed Radionuclide Cancer Therapy – Experimental Findings -- Animal Cancer Therapy Models – Ready Translation to Humans -- An Overview of Regulations of Radiopharmaceuticals -- Locoregional Radionuclide Cancer Therapy (LRCT) Using Sealed & Unsealed Radionuclides.

This book reviews locoregional radionuclide cancer therapies (LRCT). Proving an increasingly viable alternative to radiotherapy, radionuclide therapy includes a diversity of choices of well characterized biochemical and physiologic target molecules. The delivery and retention of radionuclides may be monitored by advanced imaging for exact tissue localization and for real-time dosimetry to enable personalized precision medicine. Radiopharmaceuticals in human cancer therapies are typically delivered in systemic routes but can also be designed for locoregional routes to harness pharmacokinetic advantages of higher payload and lower systemic toxicities. This book explores the latest advancements and clinical considerations of the locoregional approach. Throughout the chapters, the clinical and scientific bases of cancer treatment and the locoregional use of radionculides are explored. Mathematical models of radiation dosimetry of locoregional radionculdies on tissues are studied using common models for multiple commercially available radionuclides. Rodent and canine tumor models of LRCT are compared for selected radionuclides and radiopharmaceuticals. The practical aspects of radiopharmaceuticals production, marketing, transport, as well as radiation protection are reviewed. Finally, the combination of LRCT with immunotherapy and other cancer therapies and prospective future use of LRCT are discussed. This is a guide for practicing nuclear physicians, interventional radiologists, radiation oncologists, radiation scientists, veterinarians and oncologists to expand their knowledge base and to prepare for designing locoregional radionuclide cancer therapies in animals and in humans.

ISBN: 9783030562670

Standard No.: 10.1007/978-3-030-56267-0doiSubjects--Topical Terms:

673902
Nuclear medicine.

LC Class. No.: R895-920

Dewey Class. No.: 616.07548

Locoregional Radionuclide Cancer Therapy = Clinical and Scientific Aspects /
LDR:03902nam a22003975i 4500 001 1050451
003 DE-He213
005 20211209134334.0
007 cr nn 008mamaa
008 220103s2021 sz | s |||| 0|eng d
020 $a 9783030562670 $9 978-3-030-56267-0
024 7 $a 10.1007/978-3-030-56267-0 $2 doi
035 $a 978-3-030-56267-0
050 4 $a R895-920
072 7 $a MMN $2 bicssc
072 7 $a MED080000 $2 bisacsh
072 7 $a MKR $2 thema
082 0 4 $a 616.07548 $2 23
245 1 0 $a Locoregional Radionuclide Cancer Therapy $h [electronic resource] : $b Clinical and Scientific Aspects / $c edited by Franklin C.L. Wong.
250 $a 1st ed. 2021.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2021.
300 $a XII, 268 p. 76 illus., 56 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
505 0 $a Human Cancer- Epidemiology, Hallmarks, and Defense Strategies -- Cancer Treatment Modalities Systemic and Loco regional Approaches: Challenges and Opportunities of multidisciplinary approaches -- Cancer Radiotherapy: General Considerations and Human Radiobiology -- Radionuclide Cancer Therapy- Unsealed Alpha, Beta and Gamma Emitters -- Locoregional Therapy – Cancer Interventions with and without Radionuclides -- Radiation Dosimetry Considerations of Locoregional Radionuclide Cancer Therapy -- Voxel-based Targeted Radionuclide Therapy Dosimetry -- Locoregional Unsealed Radionuclide Cancer Therapy – Experimental Findings -- Animal Cancer Therapy Models – Ready Translation to Humans -- An Overview of Regulations of Radiopharmaceuticals -- Locoregional Radionuclide Cancer Therapy (LRCT) Using Sealed & Unsealed Radionuclides.
520 $a This book reviews locoregional radionuclide cancer therapies (LRCT). Proving an increasingly viable alternative to radiotherapy, radionuclide therapy includes a diversity of choices of well characterized biochemical and physiologic target molecules. The delivery and retention of radionuclides may be monitored by advanced imaging for exact tissue localization and for real-time dosimetry to enable personalized precision medicine. Radiopharmaceuticals in human cancer therapies are typically delivered in systemic routes but can also be designed for locoregional routes to harness pharmacokinetic advantages of higher payload and lower systemic toxicities. This book explores the latest advancements and clinical considerations of the locoregional approach. Throughout the chapters, the clinical and scientific bases of cancer treatment and the locoregional use of radionculides are explored. Mathematical models of radiation dosimetry of locoregional radionculdies on tissues are studied using common models for multiple commercially available radionuclides. Rodent and canine tumor models of LRCT are compared for selected radionuclides and radiopharmaceuticals. The practical aspects of radiopharmaceuticals production, marketing, transport, as well as radiation protection are reviewed. Finally, the combination of LRCT with immunotherapy and other cancer therapies and prospective future use of LRCT are discussed. This is a guide for practicing nuclear physicians, interventional radiologists, radiation oncologists, radiation scientists, veterinarians and oncologists to expand their knowledge base and to prepare for designing locoregional radionuclide cancer therapies in animals and in humans.
650 0 $a Nuclear medicine. $3 673902
650 0 $a Radiology. $3 673943
650 0 $a Internal medicine. $3 644638
650 1 4 $a Nuclear Medicine. $3 673045
650 2 4 $a Imaging / Radiology. $3 669876
650 2 4 $a Internal Medicine. $3 668583
700 1 $a Wong, Franklin C.L. $e editor. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1354776
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783030562663
776 0 8 $i Printed edition: $z 9783030562687
776 0 8 $i Printed edition: $z 9783030562694
856 4 0 $u https://doi.org/10.1007/978-3-030-56267-0
912 $a ZDB-2-SME
912 $a ZDB-2-SXM
950 $a Medicine (SpringerNature-11650)
950 $a Medicine (R0) (SpringerNature-43714)