國立虎尾科技大學 |

Drug Delivery in Dermatology = Fundamental and Practical Applications /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Drug Delivery in Dermatology / edited by Célia Luiza Petersen Vitello Kalil, Valéria Campos.
Reminder of title:	Fundamental and Practical Applications /
other author:	Kalil, Célia Luiza Petersen Vitello.
Description:	XIII, 208 p. 85 illus., 83 illus. in color.online resource. :
Contained By:	Springer Nature eBook
Subject:	Dermatology. -
Online resource:	https://doi.org/10.1007/978-3-030-81807-4
ISBN:	9783030818074

Drug Delivery in Dermatology = Fundamental and Practical Applications /
Drug Delivery in Dermatology Fundamental and Practical Applications /[electronic resource] :edited by Célia Luiza Petersen Vitello Kalil, Valéria Campos. - 1st ed. 2021. - XIII, 208 p. 85 illus., 83 illus. in color.online resource.

Chapter 1. Understanding Skin and Drug Delivery -- Chapter 2. How to Optimize Drug Delivery in Dermatology? -- Chapter 3. Dermatological Applications of Drug Delivery Systems -- Chapter 4. Drug Delivery-Associated Dermatological Technologies and Techniques -- Chapter 5. Microneedling and Drug Delivery -- Chapter 6. Intense Pulsed Light and Drug Delivery -- Chapter 7. Fractional Non-Ablative Laser and Drug Delivery -- Chapter 8. Ablative Fractional Lasers & Drug Delivery -- Chapter 9. Switched and Drug Delivery -- Chapter 10. Radiofrequency, Infra-red and Others Technologies for Drug Delivery -- Chapter 11. Drug Delivery in the Treatment of Alopecia -- Chapter 12. Digital Microneedling and Drug Delivery -- Chapter 13. Active Agents in Injectable Drug Delivery -- Chapter 14. Microinfusion of Drugs into the Skin (MMP®) & Drug Delivery -- Chapter 15. Protocols for Drug Delivery.

Skin accounts for approximately 15% of an adult’s total body weight, with a surface of about 2m². It provides an entry and exit barrier to various substances, offers effective protection against harmful substances, microorganisms and ultraviolet radiation, and is also paramount in immunology and body homeostasis, preventing dehydration and loss of essential minerals. The topical route has a number of advantages over oral and parenteral routes: no first-pass metabolism, greater convenience resulting in better treatment compliance, lower side-effect frequency, and prompt dosing cessation if required. However, the stratum corneum allows penetration of only 1 to 5% of substances applied topically, making this application route much less efficient. Lipophilic and small molecules (up to 500 Da) can cross the stratum corneum, since keratinocytes are covered by a lipid matrix, while it is virtually impossible for hydrophilic and large drugs to cross intact, normal skin, which means that passive topical delivery is restricted. To address this, techniques have been developed aimed at optimizing drug skin penetration by means of chemical, mechanical and physical methods, such as adding permeating active agents and using occlusion, iontophoresis, microneedling, lasers and intense pulsed light, and it is now possible to deliver medication to different skin layers or transdermally to the systemic circulation. Drug delivery is a hot topic in dermatology, with a Pubmed search generating 203431 articles. Offering a detailed review of this emerging therapeutic option, including the various methods available, this unique book guides physicians and doctors in selecting the correct technologies, technique and products for each patient. .

ISBN: 9783030818074

Standard No.: 10.1007/978-3-030-81807-4doiSubjects--Topical Terms:

669082
Dermatology.

LC Class. No.: RL1-803

Dewey Class. No.: 616.5

Drug Delivery in Dermatology = Fundamental and Practical Applications /
LDR:04023nam a22003975i 4500 001 1051403
003 DE-He213
005 20210919132546.0
007 cr nn 008mamaa
008 220103s2021 sz | s |||| 0|eng d
020 $a 9783030818074 $9 978-3-030-81807-4
024 7 $a 10.1007/978-3-030-81807-4 $2 doi
035 $a 978-3-030-81807-4
050 4 $a RL1-803
072 7 $a MJK $2 bicssc
072 7 $a MED017000 $2 bisacsh
072 7 $a MJK $2 thema
082 0 4 $a 616.5 $2 23
245 1 0 $a Drug Delivery in Dermatology $h [electronic resource] : $b Fundamental and Practical Applications / $c edited by Célia Luiza Petersen Vitello Kalil, Valéria Campos.
250 $a 1st ed. 2021.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2021.
300 $a XIII, 208 p. 85 illus., 83 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
505 0 $a Chapter 1. Understanding Skin and Drug Delivery -- Chapter 2. How to Optimize Drug Delivery in Dermatology? -- Chapter 3. Dermatological Applications of Drug Delivery Systems -- Chapter 4. Drug Delivery-Associated Dermatological Technologies and Techniques -- Chapter 5. Microneedling and Drug Delivery -- Chapter 6. Intense Pulsed Light and Drug Delivery -- Chapter 7. Fractional Non-Ablative Laser and Drug Delivery -- Chapter 8. Ablative Fractional Lasers & Drug Delivery -- Chapter 9. Switched and Drug Delivery -- Chapter 10. Radiofrequency, Infra-red and Others Technologies for Drug Delivery -- Chapter 11. Drug Delivery in the Treatment of Alopecia -- Chapter 12. Digital Microneedling and Drug Delivery -- Chapter 13. Active Agents in Injectable Drug Delivery -- Chapter 14. Microinfusion of Drugs into the Skin (MMP®) & Drug Delivery -- Chapter 15. Protocols for Drug Delivery.
520 $a Skin accounts for approximately 15% of an adult’s total body weight, with a surface of about 2m². It provides an entry and exit barrier to various substances, offers effective protection against harmful substances, microorganisms and ultraviolet radiation, and is also paramount in immunology and body homeostasis, preventing dehydration and loss of essential minerals. The topical route has a number of advantages over oral and parenteral routes: no first-pass metabolism, greater convenience resulting in better treatment compliance, lower side-effect frequency, and prompt dosing cessation if required. However, the stratum corneum allows penetration of only 1 to 5% of substances applied topically, making this application route much less efficient. Lipophilic and small molecules (up to 500 Da) can cross the stratum corneum, since keratinocytes are covered by a lipid matrix, while it is virtually impossible for hydrophilic and large drugs to cross intact, normal skin, which means that passive topical delivery is restricted. To address this, techniques have been developed aimed at optimizing drug skin penetration by means of chemical, mechanical and physical methods, such as adding permeating active agents and using occlusion, iontophoresis, microneedling, lasers and intense pulsed light, and it is now possible to deliver medication to different skin layers or transdermally to the systemic circulation. Drug delivery is a hot topic in dermatology, with a Pubmed search generating 203431 articles. Offering a detailed review of this emerging therapeutic option, including the various methods available, this unique book guides physicians and doctors in selecting the correct technologies, technique and products for each patient. .
650 0 $a Dermatology. $3 669082
650 0 $a Surgery. $3 644132
700 1 $a Kalil, Célia Luiza Petersen Vitello. $e editor. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1355908
700 1 $a Campos, Valéria. $e editor. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1355909
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783030818067
776 0 8 $i Printed edition: $z 9783030818081
776 0 8 $i Printed edition: $z 9783030818098
856 4 0 $u https://doi.org/10.1007/978-3-030-81807-4
912 $a ZDB-2-SME
912 $a ZDB-2-SXM
950 $a Medicine (SpringerNature-11650)
950 $a Medicine (R0) (SpringerNature-43714)