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Development of In-Tether Carbon Chiral Center-Induced Helical Peptide = Methodology and Applications /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Development of In-Tether Carbon Chiral Center-Induced Helical Peptide/ by Kuan Hu.
其他題名:	Methodology and Applications /
作者:	Hu, Kuan.
面頁冊數:	XV, 102 p. 75 illus., 65 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Cancer Research. -
電子資源:	https://doi.org/10.1007/978-981-33-6613-8
ISBN:	9789813366138

Development of In-Tether Carbon Chiral Center-Induced Helical Peptide = Methodology and Applications /
Hu, Kuan.

Development of In-Tether Carbon Chiral Center-Induced Helical PeptideMethodology and Applications /[electronic resource] :by Kuan Hu. - 1st ed. 2021. - XV, 102 p. 75 illus., 65 illus. in color.online resource. - Springer Theses, Recognizing Outstanding Ph.D. Research,2190-5061. - Springer Theses, Recognizing Outstanding Ph.D. Research,.

Introduction -- Method to construct in-tether chiral center constrained helical peptide -- Application in disrupting p53/MDM2 protein-protein interactions -- Fabrication of nanomaterials with in-tether chiral center constrained helical peptide.

This book focuses on the development of stapled peptides, a novel molecular modality used to regulate aberrant intracellular protein–protein interactions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determine the secondary structure of a peptide, and that the R-configured peptide is helical, while the S-configured peptide is non-helical. Further, it reports that helicity-enhanced R isomer peptides displayed significantly enhanced cell permeability and target binding affinity, as well as tumor inhibition efficiency, in comparison to S isomer peptides. The book will not only advance readers’ understanding of the basic principle of stapled peptides, but also accelerate the clinical transformation of stapled peptide drugs. .

ISBN: 9789813366138

Standard No.: 10.1007/978-981-33-6613-8doiSubjects--Topical Terms:

668358
Cancer Research.

LC Class. No.: QD241-441

Dewey Class. No.: 547

Development of In-Tether Carbon Chiral Center-Induced Helical Peptide = Methodology and Applications /
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