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Scanning Ion Conductance Microscopy

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Scanning Ion Conductance Microscopy/ edited by Tilman E. Schäffer.
其他作者:	Schäffer, Tilman E.
面頁冊數:	XI, 230 p.online resource. :
Contained By:	Springer Nature eBook
標題:	Biomaterials-Cells. -
電子資源:	https://doi.org/10.1007/978-3-031-14443-1
ISBN:	9783031144431

Scanning Ion Conductance Microscopy
Scanning Ion Conductance Microscopy[electronic resource] /edited by Tilman E. Schäffer. - 1st ed. 2022. - XI, 230 p.online resource. - Bioanalytical Reviews,31867-2094 ;. - Bioanalytical Reviews,5.

The evolution of scanning ion conductance microscopy -- Scanning ion conductance microscopy and atomic force microscopy: A comparison of strengths and limitations for biological investigations -- Ions and electrons with scanning ion conductance microscopy -- Ion channel recording with a smart patch-clamp system -- Understanding cardiac structure and function at nanoscale resolution with SICM -- Local Electrochemical Characterization using Scanning Electrochemical Cell Microscopy -- Comparison of scanning ion conductance microscopy with scanning electron microscopy for imaging cells and tissues -- Correlating scanning ion conductance and super-resolved fluorescence microscopy.

This book provides a selection of recent developments in scanning ion conductance microscopy (SICM) technology and applications. In recent years, SICM has been applied in an ever-increasing number of areas in the bioanalytical sciences. SICM is based on an electrolyte-filled nanopipette with a nanometer-scale opening, over which an electric potential is applied. The induced ion current is measured, which allows to directly or indirectly quantify various physical quantities such as pipette-sample distance, ion concentration, sample elastic modulus among many others. This makes SICM well suited for applications in electrolytes - most prominently for the study of live cells. This book starts with a historic overview starting from the days of the invention of SICM by Paul Hansma at the University of California at Santa Barbara in 1989. SICM is a member of the family of scanning probe microscopies. It is related to another prominent member of the family, atomic force microscopy (AFM), which has found application in almost any field of nanoscale science. The advantages and disadvantages of SICM over AFM are also outlined. One of the most effective and break-through applications of SICM nanopipettes is in electrochemistry. The different routes and applications for doing electrochemistry using nanopipettes are also discussed. In addition the book highlights the ability of SICM for surface positioning with nanometer precision to open up new vistas in patch clamp measurements subcellular structures. Finally the book presents one research area where SICM has been making a lot of contributions, cardiac research and the endeavors to combine SICM with super-resolution optical microscopy for highest-resolution joint topography and functional imaging.

ISBN: 9783031144431

Standard No.: 10.1007/978-3-031-14443-1doiSubjects--Topical Terms:

1389833
Biomaterials-Cells.

LC Class. No.: TA417.23

Dewey Class. No.: 620.112

Scanning Ion Conductance Microscopy
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