國立虎尾科技大學 |

PI3K and AKT Isoforms in Immunity = Mechanisms and Therapeutic Opportunities /

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	PI3K and AKT Isoforms in Immunity / edited by Margarita Dominguez-Villar.
其他題名:	Mechanisms and Therapeutic Opportunities /
其他作者:	Dominguez-Villar, Margarita.
面頁冊數:	VII, 466 p. 42 illus., 37 illus. in color.online resource. :
Contained By:	Springer Nature eBook
標題:	Adaptive Immunity. -
電子資源:	https://doi.org/10.1007/978-3-031-06566-8
ISBN:	9783031065668

PI3K and AKT Isoforms in Immunity = Mechanisms and Therapeutic Opportunities /
PI3K and AKT Isoforms in Immunity Mechanisms and Therapeutic Opportunities /[electronic resource] :edited by Margarita Dominguez-Villar. - 1st ed. 2022. - VII, 466 p. 42 illus., 37 illus. in color.online resource. - Current Topics in Microbiology and Immunology,4362196-9965 ;. - Current Topics in Microbiology and Immunology,387.

Class I PI3K biology -- Class II PI3K biology -- Class III PI3K biology -- PTEN in immunity -- PHLPP Signaling in Immune Cells -- PHLPP Signaling in Immune Cells -- PI3K isoforms in cell signalling and innate immune cell responses -- AKT isoforms in macrophage activation, polarization and survival -- Control of CD4+ T cell Differentiation and Function by PI3K isoforms. -- PI3K isoforms in CD8+ T cell development and function -- PI3K isoforms in B cells -- PI3K isoform signalling in platelets -- PI3K isoforms in vascular biology, a focus on the vascular system-immune response connection -- PI3K and AKT at the Interface of Signaling and Metabolism -- The Role of PI3K Isoforms in Autoimmune Disease -- AKT Isoforms in the Immune Response in Cancer -- PI3K isoform immunotherapy for solid tumours -- PI3K targeting in non-solid cancer -- AKT isoforms as a target in cancer and immunotherapy -- Developing PI3K Inhibitors for Respiratory Diseases.

This book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death. Recent work has highlighted the multiple roles of PI3K classes and subunits and their involvement in the immune response to the body’s own and foreign antigens and diseases such as cancer and autoimmunity. This book offers a detailed introduction to the biology of the three PI3K classes, followed by an extensive discussion of the diverse roles of AKT and PI3K isoforms in immune cells. Based on this knowledge, it subsequently explains in more detail how specific isoforms are connected to immune-mediated diseases. The book concludes by highlighting the latest advances in the production of isoform-specific inhibitors and their use in various human diseases. This book is intended as a reference guide for students and researchers interested in the multifaceted aspects of PI3K biology.

ISBN: 9783031065668

Standard No.: 10.1007/978-3-031-06566-8doiSubjects--Topical Terms:

1390598
Adaptive Immunity.

LC Class. No.: QR180-189.5

Dewey Class. No.: 571.96

PI3K and AKT Isoforms in Immunity = Mechanisms and Therapeutic Opportunities /
LDR:03571nam a22004215i 4500 001 1084323
003 DE-He213
005 20221015195904.0
007 cr nn 008mamaa
008 221228s2022 sz | s |||| 0|eng d
020 $a 9783031065668 $9 978-3-031-06566-8
024 7 $a 10.1007/978-3-031-06566-8 $2 doi
035 $a 978-3-031-06566-8
050 4 $a QR180-189.5
072 7 $a MJCM $2 bicssc
072 7 $a MED044000 $2 bisacsh
072 7 $a MJCM $2 thema
082 0 4 $a 571.96 $2 23
082 0 4 $a 616.079 $2 23
245 1 0 $a PI3K and AKT Isoforms in Immunity $h [electronic resource] : $b Mechanisms and Therapeutic Opportunities / $c edited by Margarita Dominguez-Villar.
250 $a 1st ed. 2022.
264 1 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2022.
300 $a VII, 466 p. 42 illus., 37 illus. in color. $b online resource.
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
347 $a text file $b PDF $2 rda
490 1 $a Current Topics in Microbiology and Immunology, $x 2196-9965 ; $v 436
505 0 $a Class I PI3K biology -- Class II PI3K biology -- Class III PI3K biology -- PTEN in immunity -- PHLPP Signaling in Immune Cells -- PHLPP Signaling in Immune Cells -- PI3K isoforms in cell signalling and innate immune cell responses -- AKT isoforms in macrophage activation, polarization and survival -- Control of CD4+ T cell Differentiation and Function by PI3K isoforms. -- PI3K isoforms in CD8+ T cell development and function -- PI3K isoforms in B cells -- PI3K isoform signalling in platelets -- PI3K isoforms in vascular biology, a focus on the vascular system-immune response connection -- PI3K and AKT at the Interface of Signaling and Metabolism -- The Role of PI3K Isoforms in Autoimmune Disease -- AKT Isoforms in the Immune Response in Cancer -- PI3K isoform immunotherapy for solid tumours -- PI3K targeting in non-solid cancer -- AKT isoforms as a target in cancer and immunotherapy -- Developing PI3K Inhibitors for Respiratory Diseases.
520 $a This book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death. Recent work has highlighted the multiple roles of PI3K classes and subunits and their involvement in the immune response to the body’s own and foreign antigens and diseases such as cancer and autoimmunity. This book offers a detailed introduction to the biology of the three PI3K classes, followed by an extensive discussion of the diverse roles of AKT and PI3K isoforms in immune cells. Based on this knowledge, it subsequently explains in more detail how specific isoforms are connected to immune-mediated diseases. The book concludes by highlighting the latest advances in the production of isoform-specific inhibitors and their use in various human diseases. This book is intended as a reference guide for students and researchers interested in the multifaceted aspects of PI3K biology.
650 2 4 $a Adaptive Immunity. $3 1390598
650 2 4 $a Cell Biology. $3 593889
650 2 4 $a Immune Cell Signalling. $3 1390597
650 0 $a Immunospecificity. $3 1390596
650 0 $a Autoimmunity. $3 668551
650 0 $a Cytology. $3 599554
650 0 $a Cellular signal transduction. $3 582607
650 0 $a Immune system. $3 679775
650 0 $a Immunology. $3 592892
700 1 $a Dominguez-Villar, Margarita. $e editor. $4 edt $4 http://id.loc.gov/vocabulary/relators/edt $3 1390595
710 2 $a SpringerLink (Online service) $3 593884
773 0 $t Springer Nature eBook
776 0 8 $i Printed edition: $z 9783031065651
776 0 8 $i Printed edition: $z 9783031065675
776 0 8 $i Printed edition: $z 9783031065682
830 0 $a Current Topics in Microbiology and Immunology, $x 0070-217X ; $v 387 $3 1254330
856 4 0 $u https://doi.org/10.1007/978-3-031-06566-8
912 $a ZDB-2-SBL
912 $a ZDB-2-SXB
950 $a Biomedical and Life Sciences (SpringerNature-11642)
950 $a Biomedical and Life Sciences (R0) (SpringerNature-43708)